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Tgfbr3l transforming growth factor, beta receptor III-like [ Mus musculus (house mouse) ]

Gene ID: 100044509, updated on 9-Aug-2024

Summary

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Official Symbol
Tgfbr3lprovided by MGI
Official Full Name
transforming growth factor, beta receptor III-likeprovided by MGI
Primary source
MGI:MGI:3833469
See related
Ensembl:ENSMUSG00000089736 AllianceGenome:MGI:3833469
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm14378; TGFR-3L
Summary
Predicted to enable glycosaminoglycan binding activity; transforming growth factor beta-activated receptor activity; and type II transforming growth factor beta receptor binding activity. Predicted to contribute to transforming growth factor beta binding activity. Predicted to be involved in several processes, including epithelial to mesenchymal transition; regulation of transforming growth factor beta receptor signaling pathway; and transforming growth factor beta receptor signaling pathway. Predicted to be active in cell surface and extracellular space. Orthologous to human TGFBR3L (transforming growth factor beta receptor 3 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 77.5), adrenal adult (RPKM 71.4) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Tgfbr3l in Genome Data Viewer
Location:
8 A1.1; 8 1.99 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (4297994..4301528)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (4248214..4251423)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 8 family, member E Neighboring gene mitogen-activated protein kinase kinase 7 Neighboring gene small nuclear RNA activating complex, polypeptide 2 Neighboring gene cortexin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TGFBR3L is an inhibin B co-receptor that regulates female fertility. Brûlé E, et al. Sci Adv, 2021 Dec 17. PMID 34910520, Free PMC Article
  2. Steroidogenic Factor 1 Regulates Transcription of the Inhibin B Coreceptor in Pituitary Gonadotrope Cells. Lin YF, et al. Endocrinology, 2022 Oct 11. PMID 35957608, Free PMC Article
  3. Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality. Sah RK, et al. Int J Mol Sci, 2020 Nov 3. PMID 33153107, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Steroidogenic Factor 1 Regulates Transcription of the Inhibin B Coreceptor in Pituitary Gonadotrope Cells.
    Title: Steroidogenic Factor 1 Regulates Transcription of the Inhibin B Coreceptor in Pituitary Gonadotrope Cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glycosaminoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to transforming growth factor beta binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transforming growth factor beta receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables type II transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epithelial to mesenchymal transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transforming growth factor-beta receptor type 3-like protein
Names
TGF-beta receptor type-3-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195258.1 → NP_001182187.1  transforming growth factor-beta receptor type 3-like protein precursor

    Status: PROVISIONAL

    Source sequence(s)
    AC123029
    Consensus CDS
    CCDS57603.1
    UniProtKB/Swiss-Prot
    D3YZZ2
    Related
    ENSMUSP00000106621.2, ENSMUST00000110993.2
    Conserved Domains (1) summary
    pfam00100
    Location:52 → 148
    Zona_pellucida; Zona pellucida-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    4297994..4301528
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153694.1 → XP_036009587.1  transforming growth factor-beta receptor type 3-like protein isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:18 → 277
    PHA03247; large tegument protein UL36; Provisional
    cl27758
    Location:88 → 199
    Zona_pellucida; Zona pellucida-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3YZZ2.1 GenPept UniProtKB/Swiss-Prot:D3YZZ2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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