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CXCL16 C-X-C motif chemokine ligand 16 [ Equus caballus (horse) ]

Gene ID: 100061442, updated on 8-Mar-2024

Summary

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Official Symbol
CXCL16provided by VGNC
Official Full Name
C-X-C motif chemokine ligand 16provided by VGNC
Primary source
VGNC:VGNC:16984
See related
Ensembl:ENSECAG00000018406
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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See CXCL16 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
5
Annotation release Status Assembly Chr Location
103 current EquCab3.0 (GCF_002863925.1) 11 NC_009154.3 (50086056..50090157)
102 previous assembly EquCab2.0 (GCF_000002305.2) 11 NC_009154.2 (49745879..49749980)

Chromosome 11 - NC_009154.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102149733 Neighboring gene transmembrane 4 L six family member 5 Neighboring gene zinc finger MYND-type containing 15 Neighboring gene mediator complex subunit 11 Neighboring gene proline, glutamate and leucine rich protein 1 Neighboring gene arrestin beta 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spread of equine arteritis virus among Hucul horses with different EqCXCL16 genotypes and analysis of viral quasispecies from semen of selected stallions. Socha W, et al. Sci Rep, 2020 Feb 19. PMID 32076048, Free PMC Article
  2. Allelic Variation in CXCL16 Determines CD3+ T Lymphocyte Susceptibility to Equine Arteritis Virus Infection and Establishment of Long-Term Carrier State in the Stallion. Sarkar S, et al. PLoS Genet, 2016 Dec. PMID 27930647, Free PMC Article
  3. Equine Arteritis Virus Uses Equine CXCL16 as an Entry Receptor. Sarkar S, et al. J Virol, 2016 Jan 13. PMID 26764004, Free PMC Article
  4. Equine arteritis virus long-term persistence is orchestrated by CD8+ T lymphocyte transcription factors, inhibitory receptors, and the CXCL16/CXCR6 axis. Carossino M, et al. PLoS Pathog, 2019 Jul. PMID 31356622, Free PMC Article
  5. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spread of equine arteritis virus among Hucul horses with different EqCXCL16 genotypes and analysis of viral quasispecies from semen of selected stallions.
    Title: Spread of equine arteritis virus among Hucul horses with different EqCXCL16 genotypes and analysis of viral quasispecies from semen of selected stallions.
  2. The findings herein are novel and strongly suggest that RNA viruses such as equine arteritis virus could exploit the CXCL16/CXCR6 axis in order to modulate local inflammatory and immune responses in the male reproductive tract by inducing a dysfunctional CD8+ T lymphocyte response and unique lymphocyte homing in the reproductive tract.
    Title: Equine arteritis virus long-term persistence is orchestrated by CD8+ T lymphocyte transcription factors, inhibitory receptors, and the CXCL16/CXCR6 axis.
  3. the protein isoform EqCXCL16S but not EqCXCL16R can function as an EAV cellular receptor. Although both molecules have equal chemoattractant potential, EqCXCL16S has significantly higher scavenger receptor and adhesion properties compared to EqCXCL16R.
    Title: Allelic Variation in CXCL16 Determines CD3+ T Lymphocyte Susceptibility to Equine Arteritis Virus Infection and Establishment of Long-Term Carrier State in the Stallion.
  4. EqCXCL16 acts as an equine arteritis virus entry receptor in equine arteritis virus-susceptible cells, equine monocytes.
    Title: Equine Arteritis Virus Uses Equine CXCL16 as an Entry Receptor.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables chemokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables low-density lipoprotein particle receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to type II interferon IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
C-X-C motif chemokine 16

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009154.3 Reference EquCab3.0 Primary Assembly

    Range
    50086056..50090157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001504756.6 → XP_001504806.1  C-X-C motif chemokine 16

    See identical proteins and their annotated locations for XP_001504806.1

    UniProtKB/TrEMBL
    F7CTX0

  2. XM_023653383.1 → XP_023509151.1  C-X-C motif chemokine 16

    UniProtKB/TrEMBL
    F7CTX0
    Related
    ENSECAP00000015940.3, ENSECAT00000019475.3
Nucleotide Protein
Heading Accession and Version

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