EGOT eosinophil granule ontogeny transcript [Homo sapiens (human)] - Gene

Summary

Official Symbol: EGOTprovided by HGNC
Official Full Name: eosinophil granule ontogeny transcriptprovided by HGNC
Primary source: HGNC:HGNC:37129
See related: Ensembl:ENSG00000235947 MIM:611662; AllianceGenome:HGNC:37129
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EGO; NCRNA00190
Summary: Biomarker of congestive heart failure. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in kidney (RPKM 3.9), gall bladder (RPKM 0.4) and 1 other tissue See more
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Genomic context

Location:: 3p26.1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (4749192..4751590, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (4743052..4745450, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (4790876..4793274, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Evaluation of long non-coding RNAs EGOT, NRAV, NRIR and mRNAs ISG15 and IFITM3 expressions in COVID-19 patients.
Title: Evaluation of long non-coding RNAs EGOT, NRAV, NRIR and mRNAs ISG15 and IFITM3 expressions in COVID-19 patients.
Comprehensive Analysis of Competing Endogenous RNA Network Focusing on Long Noncoding RNA Involved in Cirrhotic Hepatocellular Carcinoma.
Title: Comprehensive Analysis of Competing Endogenous RNA Network Focusing on Long Noncoding RNA Involved in Cirrhotic Hepatocellular Carcinoma.
LncRNA EGOT decreases breast cancer cell viability and migration via inactivation of the Hedgehog pathway.
Title: LncRNA EGOT decreases breast cancer cell viability and migration via inactivation of the Hedgehog pathway.
EGOT functions as an oncogene in GC, and may be useful as a conceivable diagnostic and prognostic biomarker for GC tumorigenesis.
Title: LncRNA EGOT Promotes Tumorigenesis Via Hedgehog Pathway in Gastric Cancer.
EGOT-enhancing autophagy sensitizes paclitaxel cytotoxicity via upregulation of ITPR1 expression by RNA-RNA and RNA-protein interactions in human breast cancer.
Title: Ai-lncRNA EGOT enhancing autophagy sensitizes paclitaxel cytotoxicity via upregulation of ITPR1 expression by RNA-RNA and RNA-protein interactions in human cancer.
EGOT is involved in the progression of head and neck squamous cell carcinomas (HSNCC) and seems particularly associated with virus-related forms of HNSCC.
Title: EGOT lncRNA in head and neck squamous cell carcinomas.
Upregulation of lncRNA EGOT by transfection of 786O and ACHN RCC cells with pcDNA3.1EGOT suppressed cell proliferation, migration and invasion, and induced RCC cell apoptosis.
Title: Identification of lncRNA EGOT as a tumor suppressor in renal cell carcinoma.
Our results suggest that EGOT is a lncRNA induced after infection that increases viral replication by antagonizing the antiviral response.
Title: Long noncoding RNA EGOT negatively affects the antiviral response and favors HCV replication.
EGOT may play an important role in breast cancer progression and prognosis and may serve as a new potential prognostic target in breast cancer patients.
Title: Downregulation of the long noncoding RNA EGOT correlates with malignant status and poor prognosis in breast cancer.
EGO is a novel ncRNA gene expressed during eosinophil development and is necessary for normal MBP and EDN transcript expression.
Title: EGO, a novel, noncoding RNA gene, regulates eosinophil granule protein transcript expression.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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General gene information

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Other Names

eosinophil granule ontogeny transcript (non-protein coding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.