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ZNF705G zinc finger protein 705G [ Homo sapiens (human) ]

Gene ID: 100131980, updated on 27-Nov-2024

Summary

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Official Symbol
ZNF705Gprovided by HGNC
Official Full Name
zinc finger protein 705Gprovided by HGNC
Primary source
HGNC:HGNC:37134
See related
Ensembl:ENSG00000215372 AllianceGenome:HGNC:37134
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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See ZNF705G in Genome Data Viewer
Location:
8p23.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (7355517..7385558, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (7020087..7114544, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (7213039..7243080, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 66 member B Neighboring gene ubiquitin specific peptidase 17 like family member 4 Neighboring gene ubiquitin carboxyl-terminal hydrolase 17-like protein 2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26961 Neighboring gene defensin beta 108C Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:7251267-7252216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:7253130-7253706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:7253707-7254283 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:7259671-7260248 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:7264652-7265597 Neighboring gene defensin beta 4B Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DNA sequence and analysis of human chromosome 8. Nusbaum C, et al. Nature, 2006 Jan 19. PMID 16421571
  2. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? Nathan JA, et al. EMBO J, 2013 Feb 20. PMID 23314748, Free PMC Article
  3. DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples. Jiao F, et al. J Proteome Res, 2024 Aug 2. PMID 38334954, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative zinc finger protein 705G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164457.3 → NP_001157929.1  putative zinc finger protein 705G

    See identical proteins and their annotated locations for NP_001157929.1

    Status: VALIDATED

    Source sequence(s)
    AC130360
    Consensus CDS
    CCDS47773.1
    UniProtKB/Swiss-Prot
    A8MUZ8
    Related
    ENSP00000383020.4, ENST00000400156.4
    Conserved Domains (5) summary
    smart00349
    Location:7 → 66
    KRAB; krueppel associated box
    COG5048
    Location:92 → 246
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:174 → 194
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 46
    KRAB; KRAB box
    pfam13465
    Location:186 → 211
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    7355517..7385558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p14 PATCHES

    Range
    5523302..5609712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332218.1 → XP_054188193.1  putative zinc finger protein 705G isoform X5

  2. XM_054332227.1 → XP_054188202.1  putative zinc finger protein 705G isoform X12

  3. XM_054332222.1 → XP_054188197.1  putative zinc finger protein 705G isoform X9

  4. XM_054332223.1 → XP_054188198.1  putative zinc finger protein 705G isoform X8

  5. XM_054332214.1 → XP_054188189.1  putative zinc finger protein 705G isoform X1

  6. XM_054332217.1 → XP_054188192.1  putative zinc finger protein 705G isoform X4

  7. XM_054332216.1 → XP_054188191.1  putative zinc finger protein 705G isoform X3

  8. XM_054332228.1 → XP_054188203.1  putative zinc finger protein 705G isoform X13

  9. XM_054332224.1 → XP_054188199.1  putative zinc finger protein 705G isoform X8

  10. XM_054332215.1 → XP_054188190.1  putative zinc finger protein 705G isoform X2

  11. XM_054332225.1 → XP_054188200.1  putative zinc finger protein 705G isoform X10

  12. XM_054332221.1 → XP_054188196.1  putative zinc finger protein 705G isoform X8

  13. XM_054332220.1 → XP_054188195.1  putative zinc finger protein 705G isoform X7

  14. XM_054332229.1 → XP_054188204.1  putative zinc finger protein 705G isoform X14

  15. XM_054332226.1 → XP_054188201.1  putative zinc finger protein 705G isoform X11

  16. XM_054332219.1 → XP_054188194.1  putative zinc finger protein 705G isoform X6

RNA

  1. XR_008485749.1 RNA Sequence

  2. XR_008485750.1 RNA Sequence

  3. XR_008485751.1 RNA Sequence

  4. XR_008485752.1 RNA Sequence

  5. XR_008485754.1 RNA Sequence

  6. XR_008485753.1 RNA Sequence

  7. XR_002959146.2 RNA Sequence

  8. XR_007069096.1 RNA Sequence

  9. XR_007069094.1 RNA Sequence

  10. XR_002959142.2 RNA Sequence

  11. XR_007069099.1 RNA Sequence

  12. XR_007069101.1 RNA Sequence

  13. XR_007069100.1 RNA Sequence

  14. XR_007069097.1 RNA Sequence

  15. XR_007069095.1 RNA Sequence

  16. XR_007069103.1 RNA Sequence

  17. XR_007069102.1 RNA Sequence

  18. XR_007069098.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187570.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    39798..68296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    7020087..7114544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359517.1 → XP_054215492.1  putative zinc finger protein 705G isoform X16

  2. XM_054359518.1 → XP_054215493.1  putative zinc finger protein 705G isoform X16

  3. XM_054359519.1 → XP_054215494.1  putative zinc finger protein 705G isoform X16

  4. XM_054359516.1 → XP_054215491.1  putative zinc finger protein 705G isoform X15

  5. XM_054359521.1 → XP_054215496.1  putative zinc finger protein 705G isoform X17

  6. XM_054359520.1 → XP_054215495.1  putative zinc finger protein 705G isoform X17

  7. XM_054359523.1 → XP_054215498.1  putative zinc finger protein 705G isoform X19

  8. XM_054359522.1 → XP_054215497.1  putative zinc finger protein 705G isoform X18

RNA

  1. XR_008487791.1 RNA Sequence

  2. XR_008487789.1 RNA Sequence

  3. XR_008487790.1 RNA Sequence

  4. XR_007078653.1 RNA Sequence

  5. XR_007078654.1 RNA Sequence

  6. XR_008487792.1 RNA Sequence

  7. XR_008487788.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8MUZ8.2 GenPept UniProtKB/Swiss-Prot:A8MUZ8

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