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ZNF705B zinc finger protein 705B [ Homo sapiens (human) ]

Gene ID: 100132396, updated on 28-Oct-2024

Summary

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Official Symbol
ZNF705Bprovided by HGNC
Official Full Name
zinc finger protein 705Bprovided by HGNC
Primary source
HGNC:HGNC:32284
See related
Ensembl:ENSG00000215356 AllianceGenome:HGNC:32284
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Restricted expression toward testis (RPKM 1.0) See more
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Genomic context

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See ZNF705B in Genome Data Viewer
Location:
8p23.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (7926337..7952413)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (12072289..12100603)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (7783859..7809935)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:7760080-7761002 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:7761003-7761923 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 2 Neighboring gene defensin beta 4A Neighboring gene defensin beta 108A Neighboring gene ubiquitin carboxyl-terminal hydrolase 17-like protein 2-like Neighboring gene family with sequence similarity 66 member E Neighboring gene ubiquitin specific peptidase 17 like family member 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DNA sequence and analysis of human chromosome 8. Nusbaum C, et al. Nature, 2006 Jan 19. PMID 16421571
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 705B
Names
Putative zinc finger protein 705D-like protein LOC100132396
putative zinc finger protein 705B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193630.1 → NP_001180559.1  zinc finger protein 705B

    See identical proteins and their annotated locations for NP_001180559.1

    Status: VALIDATED

    Source sequence(s)
    AC130365, AK292586
    Consensus CDS
    CCDS55194.1
    UniProtKB/Swiss-Prot
    A8K971, A8MY01, P0CI00
    Related
    ENSP00000382987.3, ENST00000400120.3
    Conserved Domains (5) summary
    smart00349
    Location:7 → 66
    KRAB; krueppel associated box
    COG5048
    Location:116 → 300
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:174 → 194
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 46
    KRAB; KRAB box
    pfam13465
    Location:214 → 239
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    7926337..7952413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421207.1 → XP_047277163.1  zinc finger protein 705B isoform X1

    UniProtKB/Swiss-Prot
    A8K971, A8MY01, P0CI00

  2. XM_047421208.1 → XP_047277164.1  zinc finger protein 705B isoform X1

    UniProtKB/Swiss-Prot
    A8K971, A8MY01, P0CI00

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p14 PATCHES

    Range
    833818..861427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332231.1 → XP_054188206.1  zinc finger protein 705B isoform X1

    UniProtKB/TrEMBL
    A0AAG2TMI8

  2. XM_054332230.1 → XP_054188205.1  zinc finger protein 705B isoform X1

    UniProtKB/TrEMBL
    A0AAG2TMI8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    12072289..12100603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359524.1 → XP_054215499.1  zinc finger protein 705B isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CI00.1 GenPept UniProtKB/Swiss-Prot:P0CI00

Gene LinkOut

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