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ulk1a unc-51 like autophagy activating kinase 1a [ Danio rerio (zebrafish) ]

Gene ID: 100170793, updated on 9-Dec-2024

Summary

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Official Symbol
ulk1aprovided by ZNC
Official Full Name
unc-51 like autophagy activating kinase 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080723-31
See related
Ensembl:ENSDARG00000062518 AllianceGenome:ZFIN:ZDB-GENE-080723-31
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:195008
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in autophagy. Predicted to act upstream of or within protein phosphorylation and regulation of autophagy. Is expressed in liver. Orthologous to human ULK1 (unc-51 like autophagy activating kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See ulk1a in Genome Data Viewer
Location:
chromosome: 8
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (43736072..43775805, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (43742653..43782386, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496381 Neighboring gene small nucleolar RNA SNORA49 Neighboring gene E1A binding protein p400 Neighboring gene uncharacterized LOC137496382 Neighboring gene adhesion G protein-coupled receptor D1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos. He C, et al. Autophagy, 2009 May. PMID 19221467, Free PMC Article
  2. Exosc2 deficiency leads to developmental disorders by causing a nucleotide pool imbalance in zebrafish. Yatsuka H, et al. Biochem Biophys Res Commun, 2020 Dec 17. PMID 33333712
  3. Allelic heterogeneity of TTNtv dilated cardiomyopathy can be modeled in adult zebrafish. Zhu P, et al. JCI Insight, 2024 Apr 8. PMID 38412038, Free PMC Article
  4. Low-dose methylmercury exposure impairs the locomotor activity of zebrafish: Role of intestinal inositol metabolism. Zhu J, et al. Environ Res, 2020 Nov. PMID 32777273
  5. Distribution of H3K27me3, H3K9me3, and H3K4me3 along autophagy-related genes highly expressed in starved zebrafish myotubes. Biga PR, et al. Biol Open, 2017 Nov 15. PMID 29025701, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of autophagy IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase ULK1a
Names
unc-51-like kinase 1a
NP_001124103.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130631.1 → NP_001124103.1  serine/threonine-protein kinase ULK1a

    See identical proteins and their annotated locations for NP_001124103.1

    Status: PROVISIONAL

    Source sequence(s)
    BC163488
    UniProtKB/TrEMBL
    B3DJH7
    Related
    ENSDARP00000084967.3, ENSDART00000090534.6
    Conserved Domains (3) summary
    smart00220
    Location:9 → 271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14202
    Location:6 → 272
    STKc_ULK1; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1
    pfam12063
    Location:713 → 924
    DUF3543; Domain of unknown function (DUF3543)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    43736072..43775805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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