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DUX4L9 double homeobox 4 like 9 (pseudogene) [ Homo sapiens (human) ]

Gene ID: 100288711, updated on 17-Jun-2024

Summary

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Official Symbol
DUX4L9provided by HGNC
Official Full Name
double homeobox 4 like 9 (pseudogene)provided by HGNC
Primary source
HGNC:HGNC:33855
See related
Ensembl:ENSG00000224807 MIM:615581; AllianceGenome:HGNC:33855
Gene type
pseudo
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DUX4C
Summary
Enables transcription cis-regulatory region binding activity. Involved in cell population proliferation and positive regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See DUX4L9 in Genome Data Viewer
Location:
4q35.2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (190021169..190022665, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (193389387..193390883, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (190942324..190943820, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 174 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:190937742-190937939 Neighboring gene RNA, 5S ribosomal pseudogene 175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:190942591-190943245 Neighboring gene FSHD region gene 2 Neighboring gene retinoic acid receptor responder 2 pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins. Claus C, et al. Skelet Muscle, 2023 Mar 7. PMID 36882853, Free PMC Article
  2. Testing the effects of FSHD candidate gene expression in vertebrate muscle development. Wuebbles RD, et al. Int J Clin Exp Pathol, 2010 Mar 28. PMID 20490329, Free PMC Article
  3. Analysis of the tandem repeat locus D4Z4 associated with facioscapulohumeral muscular dystrophy. Hewitt JE, et al. Hum Mol Genet, 1994 Aug. PMID 7987304
  4. Fine mapping of the FSHD gene region orientates the rearranged fragment detected by the probe p13E-11. Wright TJ, et al. Hum Mol Genet, 1993 Oct. PMID 7903581
  5. The FSHD-associated repeat, D4Z4, is a member of a dispersed family of homeobox-containing repeats, subsets of which are clustered on the short arms of the acrocentric chromosomes. Lyle R, et al. Genomics, 1995 Aug 10. PMID 7490072

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins.
    Title: The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins.
  2. Interactions between DUX4 and DUX4c with cytoplasmic proteins play a major role during muscle differentiation.
    Title: Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • double homeobox 4 pseudogene
  • double homeobox 4c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027951.5 

    Range
    101..1597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    190021169..190022665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_015495300.1 Reference GRCh38.p14 PATCHES

    Range
    113770..115266 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_015495301.1 Reference GRCh38.p14 PATCHES

    Range
    113770..115266 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187650.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    358700..360196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    193389387..193390883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001023569.1: Suppressed sequence

    Description
    NM_001023569.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_001099853.1: Suppressed sequence

    Description
    NM_001099853.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version

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