U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TMEM225B transmembrane protein 225B [ Homo sapiens (human) ]

Gene ID: 100289187, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
TMEM225Bprovided by HGNC
Official Full Name
transmembrane protein 225Bprovided by HGNC
Primary source
HGNC:HGNC:53075
See related
Ensembl:ENSG00000244219 AllianceGenome:HGNC:53075
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GS1-259H13.2
Summary
Predicted to be involved in negative regulation of phosphatase activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis (RPKM 71.2) See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TMEM225B in Genome Data Viewer
Location:
7q22.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (99598058..99611045)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (100837398..100850372)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99195890..99208668)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26326 Neighboring gene family with sequence similarity 200 member A Neighboring gene zinc finger protein 655 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:99213715-99214694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99227460-99228106 Neighboring gene zinc finger and SCAN domain containing 25 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:99236540-99236705 Neighboring gene ARF GTPase 6 pseudogene Neighboring gene cytochrome P450 family 3 subfamily A member 5 Neighboring gene CYP3A5 promoter

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genome-wide association study of anthropometric traits in Korcula Island, Croatia. Polasek O, et al. Croat Med J, 2009 Feb. PMID 19260139, Free PMC Article
  2. A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220. Hou P, et al. Cancer Res, 2017 Aug 15. PMID 28625976, Free PMC Article
  3. Creation of genome-wide protein expression libraries using random activation of gene expression. Harrington JJ, et al. Nat Biotechnol, 2001 May. PMID 11329013
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of anthropometric traits in Korcula Island, Croatia.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See Variation Viewer (GRCh37.p13)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transmembrane protein 225B
Names
transmembrane protein 225-like

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195541.3 → NP_001182470.1  transmembrane protein 225B

    See identical proteins and their annotated locations for NP_001182470.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 all encode the same protein.
    Source sequence(s)
    AA781117, DB462723, DB477974, HY200726
    Consensus CDS
    CCDS87525.1
    UniProtKB/Swiss-Prot
    P0DP42
    Related
    ENSP00000492416.1, ENST00000431679.6
    Conserved Domains (1) summary
    cl21598
    Location:26 → 170
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction

  2. NM_001195542.3 → NP_001182471.1  transmembrane protein 225B

    See identical proteins and their annotated locations for NP_001182471.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 all encode the same protein.
    Source sequence(s)
    AI028251, BG461486, DB456868, DB477974, HY200726
    Consensus CDS
    CCDS87525.1
    UniProtKB/Swiss-Prot
    P0DP42
    Conserved Domains (1) summary
    cl21598
    Location:26 → 170
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction

  3. NM_001195543.3 → NP_001182472.1  transmembrane protein 225B

    See identical proteins and their annotated locations for NP_001182472.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 all encode the same protein.
    Source sequence(s)
    AA781117, AI028251, BI559535, DB477974, HY200726
    Consensus CDS
    CCDS87525.1
    UniProtKB/Swiss-Prot
    P0DP42
    Related
    ENSP00000491691.1, ENST00000453227.5
    Conserved Domains (1) summary
    cl21598
    Location:26 → 170
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    99598058..99611045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515697.2 → XP_011513999.1  transmembrane protein 225B isoform X2

    See identical proteins and their annotated locations for XP_011513999.1

    Conserved Domains (1) summary
    cl21598
    Location:41 → 185
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction

  2. XM_005250088.6 → XP_005250145.1  transmembrane protein 225B isoform X3

    See identical proteins and their annotated locations for XP_005250145.1

    UniProtKB/Swiss-Prot
    P0DP42
    Conserved Domains (1) summary
    cl21598
    Location:26 → 170
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction

  3. XM_047419688.1 → XP_047275644.1  transmembrane protein 225B isoform X2

  4. XM_024446625.2 → XP_024302393.1  transmembrane protein 225B isoform X3

    UniProtKB/Swiss-Prot
    P0DP42

  5. XM_011515696.3 → XP_011513998.1  transmembrane protein 225B isoform X2

    See identical proteins and their annotated locations for XP_011513998.1

    Conserved Domains (1) summary
    cl21598
    Location:41 → 185
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction

  6. XM_011515699.3 → XP_011514001.1  transmembrane protein 225B isoform X3

    See identical proteins and their annotated locations for XP_011514001.1

    UniProtKB/Swiss-Prot
    P0DP42
    Conserved Domains (1) summary
    cl21598
    Location:26 → 170
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction

  7. XM_024446622.2 → XP_024302390.1  transmembrane protein 225B isoform X2

  8. XM_047419690.1 → XP_047275646.1  transmembrane protein 225B isoform X3

    UniProtKB/Swiss-Prot
    P0DP42

  9. XM_047419687.1 → XP_047275643.1  transmembrane protein 225B isoform X2

  10. XM_024446624.2 → XP_024302392.1  transmembrane protein 225B isoform X3

    UniProtKB/Swiss-Prot
    P0DP42

  11. XM_047419689.1 → XP_047275645.1  transmembrane protein 225B isoform X2

  12. XM_047419691.1 → XP_047275647.1  transmembrane protein 225B isoform X3

    UniProtKB/Swiss-Prot
    P0DP42

  13. XM_011515691.3 → XP_011513993.1  transmembrane protein 225B isoform X2

    See identical proteins and their annotated locations for XP_011513993.1

    Conserved Domains (1) summary
    cl21598
    Location:41 → 185
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction

  14. XM_011515692.3 → XP_011513994.1  transmembrane protein 225B isoform X2

    See identical proteins and their annotated locations for XP_011513994.1

    Conserved Domains (1) summary
    cl21598
    Location:41 → 185
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction

  15. XM_011515695.3 → XP_011513997.1  transmembrane protein 225B isoform X2

    See identical proteins and their annotated locations for XP_011513997.1

    Conserved Domains (1) summary
    cl21598
    Location:41 → 185
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction

  16. XM_011515694.3 → XP_011513996.1  transmembrane protein 225B isoform X2

    See identical proteins and their annotated locations for XP_011513996.1

    Conserved Domains (1) summary
    cl21598
    Location:41 → 185
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction

  17. XM_024446623.2 → XP_024302391.1  transmembrane protein 225B isoform X3

    UniProtKB/Swiss-Prot
    P0DP42

  18. XM_024446621.2 → XP_024302389.1  transmembrane protein 225B isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    100837398..100850372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356961.1 → XP_054212936.1  transmembrane protein 225B isoform X3

    UniProtKB/Swiss-Prot
    P0DP42

  2. XM_054356957.1 → XP_054212932.1  transmembrane protein 225B isoform X2

  3. XM_054356959.1 → XP_054212934.1  transmembrane protein 225B isoform X3

    UniProtKB/Swiss-Prot
    P0DP42

  4. XM_054356960.1 → XP_054212935.1  transmembrane protein 225B isoform X3

    UniProtKB/Swiss-Prot
    P0DP42

  5. XM_054356962.1 → XP_054212937.1  transmembrane protein 225B isoform X3

    UniProtKB/Swiss-Prot
    P0DP42

  6. XM_054356958.1 → XP_054212933.1  transmembrane protein 225B isoform X2

  7. XM_054356953.1 → XP_054212928.1  transmembrane protein 225B isoform X2

  8. XM_054356954.1 → XP_054212929.1  transmembrane protein 225B isoform X2

  9. XM_054356955.1 → XP_054212930.1  transmembrane protein 225B isoform X2

  10. XM_054356956.1 → XP_054212931.1  transmembrane protein 225B isoform X2

  11. XM_054356963.1 → XP_054212938.1  transmembrane protein 225B isoform X3

    UniProtKB/Swiss-Prot
    P0DP42

  12. XM_054356952.1 → XP_054212927.1  transmembrane protein 225B isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DP42.1 GenPept UniProtKB/Swiss-Prot:P0DP42

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials