MIR1204 microRNA 1204 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR1204provided by HGNC
Official Full Name: microRNA 1204provided by HGNC
Primary source: HGNC:HGNC:37059
See related: Ensembl:ENSG00000283710 miRBase:MI0006337; AllianceGenome:HGNC:37059
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: hsa-mir-1204
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 8q24.21

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (127795962..127796028)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (128923451..128923517)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (128808208..128808274)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-1204 Positioning in 8q24.21 Involved in the Tumorigenesis of Colorectal Cancer by Targeting MASPIN.
Title: miR-1204 Positioning in 8q24.21 Involved in the Tumorigenesis of Colorectal Cancer by Targeting MASPIN.
MiR-1204 promotes ovarian squamous cell carcinoma growth by increasing glucose uptake.
Title: MiR-1204 promotes ovarian squamous cell carcinoma growth by increasing glucose uptake.
MiR-1204 induces apoptosis of non-small cell lung cancer cells by inhibiting the expression of DEK. The mechanism of apoptosis involves down-regulation of Bcl-2 and up-regulation of Bax expression.
Title: The miR-1204 regulates apoptosis in NSCLC cells by targeting DEK.
upregulated miR-1204 in non-small-cell lung cancer (NSCLC) is associated with NSCLC progression and promotes NSCLC cell proliferation by downregulating PITX1.
Title: MicroRNA-1204 promotes cell proliferation by regulating PITX1 in non-small-cell lung cancer.
High miR1204 expression is associated with epithelial-mesenchymal transition and metastasis in breast cancer.
Title: miR-1204 targets VDR to promotes epithelial-mesenchymal transition and metastasis in breast cancer.
MiR-1204 sensitizes nasopharyngeal carcinoma cells to paclitaxel both in vitro and in vivo
Title: MiR-1204 sensitizes nasopharyngeal carcinoma cells to paclitaxel both in vitro and in vivo.
p53-Dependent induction of PVT1 and miR-1204.
Title: p53-Dependent induction of PVT1 and miR-1204.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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General gene information

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NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.