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SLC8A1 solute carrier family 8 member A1 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100328570, updated on 2-Dec-2024

Summary

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Gene symbol
SLC8A1
Gene description
solute carrier family 8 member A1
See related
Ensembl:ENSOCUG00000010854
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as
NACA; NCX1
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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See SLC8A1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_11 current mOryCun1.1 (GCF_964237555.1) 2 NC_091433.1 (162307433..162628530)
RS_2023_02 previous assembly UM_NZW_1.0 (GCF_009806435.1) 2 NC_067375.1 (146091999..146415905)

Chromosome 2 - NC_091433.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC108176367 Neighboring gene small nucleolar RNA SNORA72 Neighboring gene uncharacterized LOC138848741 Neighboring gene E3 ubiquitin-protein ligase RNF13 pseudogene Neighboring gene serine/threonine-protein kinase 4 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Activation of Ca2+-activated Cl- channels by store-operated Ca2+ entry in arterial smooth muscle cells does not require reverse-mode Na+/Ca2+ exchange. Angermann JE, et al. Can J Physiol Pharmacol, 2012 Jul. PMID 22734601
  2. Mutually exclusive and cassette exons underlie alternatively spliced isoforms of the Na/Ca exchanger. Kofuji P, et al. J Biol Chem, 1994 Feb 18. PMID 8106495
  3. Na/Ca exchanger isoforms expressed in kidney. Kofuji P, et al. Am J Physiol, 1993 Oct. PMID 7694482
  4. cDNA cloning of a renal Na(+)-Ca2+ exchanger. Reilly RF, et al. Am J Physiol, 1992 Jun. PMID 1621815
  5. Postnatal development of transmural gradients in expression of ion channels and Ca²⁺-handling proteins in the ventricle. Abd Allah ES, et al. J Mol Cell Cardiol, 2012 Aug. PMID 22537893

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The SOCE/Cl(Ca) interaction does not require reverse-mode Na+/Ca2+ exchange in our conditions.
    Title: Activation of Ca2+-activated Cl- channels by store-operated Ca2+ entry in arterial smooth muscle cells does not require reverse-mode Na+/Ca2+ exchange.
  2. There were substantial transmural gradients in Cav1.2, KChIP2, ERG, KvLQT1, Kir2.1, NCX1, SERCA2a and RyR2 at the mRNA and, in some cases, protein level-in every case the mRNA or protein was more abundant in the epicardium than the endocardium.
    Title: Postnatal development of transmural gradients in expression of ion channels and Ca²⁺-handling proteins in the ventricle.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium:sodium antiporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell communication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sodium/calcium exchanger 1
Names
Na/Ca exchanger
sodium/calcium exchanger
solute carrier family 8 (sodium/calcium exchanger), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170958.1 → NP_001164429.1  sodium/calcium exchanger 1 precursor

    See identical proteins and their annotated locations for NP_001164429.1

    Status: PROVISIONAL

    Source sequence(s)
    U52665
    UniProtKB/TrEMBL
    G1T042, Q28662
    Related
    ENSOCUP00000009337.3, ENSOCUT00000010852.4
    Conserved Domains (5) summary
    smart00237
    Location:534 → 624
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:1 → 941
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:768 → 932
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:403 → 493
    Calx-beta; Calx-beta domain
    pfam16494
    Location:251 → 381
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

RefSeqs of Annotated Genomes: GCF_964237555.1-RS_2024_11

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOryCun1.1

Genomic

  1. NC_091433.1 Reference mOryCun1.1

    Range
    162307433..162628530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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