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LINC00674 long intergenic non-protein coding RNA 674 [ Homo sapiens (human) ]

Gene ID: 100499466, updated on 10-Dec-2024

Summary

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Official Symbol
LINC00674provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 674provided by HGNC
Primary source
HGNC:HGNC:44355
See related
AllianceGenome:HGNC:44355
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CALA
Expression
Ubiquitous expression in thyroid (RPKM 7.9), brain (RPKM 7.3) and 25 other tissues See more
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Genomic context

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See LINC00674 in Genome Data Viewer
Location:
17q24.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (68101555..68135929)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (68978345..69012721)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (66097696..66132070)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66031597-66032144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12635 Neighboring gene MPRA-validated peak2956 silencer Neighboring gene karyopherin subunit alpha 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66076452-66076952 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66076953-66077453 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:66083143-66083718 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12636 Neighboring gene uncharacterized LOC124904048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66097037-66097816 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66097817-66098595 Neighboring gene F-box protein 36 pseudogene 1 Neighboring gene leucine rich repeat containing 37 member A16, pseudogene Neighboring gene SH3 domain containing GRB2 like 1, endophilin A2 pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:66150047-66150548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:66150549-66151048 Neighboring gene uncharacterized LOC105371870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:66165711-66166210 Neighboring gene RDM1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12639 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:66180501-66181101 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12640 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12641

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Hypoxia-induced LINC00674 facilitates hepatocellular carcinoma progression by activating the NOX1/mTOR signaling pathway. Zhu N, et al. J Cancer, 2022. PMID 36118523, Free PMC Article
  2. The G3BP1-UPF1-Associated Long Non-Coding RNA CALA Regulates RNA Turnover in the Cytoplasm. Kirchhof L, et al. Noncoding RNA, 2022 Jun 30. PMID 35893232, Free PMC Article
  3. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

Other Names

  • cytoplasmic G3BP1-associated lncRNA

Clone Names

  • FLJ33831, FLJ35479

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_027418.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005332, AC145343, BC045718, DA232946

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    68101555..68135929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    68978345..69012721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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