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FALEC focally amplified long non-coding RNA in epithelial cancer [ Homo sapiens (human) ]

Gene ID: 100874054, updated on 22-Oct-2024

Summary

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Official Symbol
FALECprovided by HGNC
Official Full Name
focally amplified long non-coding RNA in epithelial cancerprovided by HGNC
Primary source
HGNC:HGNC:43713
See related
Ensembl:ENSG00000228126 MIM:616092; AllianceGenome:HGNC:43713
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAL1; ncRNA-a1; LINC00568
Expression
Low expression observed in reference dataset See more
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Genomic context

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See FALEC in Genome Data Viewer
Location:
1q21.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (150515752..150536788)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (149640590..149661674)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (150488228..150509264)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene threonyl-tRNA synthetase 2, mitochondrial Neighboring gene microRNA 6878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:150482970-150483840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1689 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1300 Neighboring gene extracellular matrix protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:150505206-150506196 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:150507812-150509011 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:150515782-150516282 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:150516283-150516783 Neighboring gene CRISPRi-validated cis-regulatory element chr1.8461 Neighboring gene ADAMTSL4 antisense RNA 2 Neighboring gene Sharpr-MPRA regulatory region 6123 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1302 Neighboring gene uncharacterized LOC124904417 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:150523090-150523779 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:150524269-150525138 Neighboring gene ADAMTS like 4 Neighboring gene microRNA 4257

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Up-regulation of lncRNA FALEC indicates prognosis and diagnosis values in cervical cancer. Naizhaer G, et al. Pathol Res Pract, 2019 Aug. PMID 31248657
  2. Long Noncoding RNA FAL1 Promotes Cell Proliferation, Invasion and Epithelial-Mesenchymal Transition Through the PTEN/AKT Signaling Axis in Non-Small Cell Lung Cancer. Pan C, et al. Cell Physiol Biochem, 2017. PMID 28854421
  3. Up-regulation of long noncoding RNA FALEC predicts poor prognosis and promotes melanoma cell proliferation through epigenetically silencing p21. Ni N, et al. Biomed Pharmacother, 2017 Dec. PMID 29196104
  4. LncRNA FAL1 is a negative prognostic biomarker and exhibits pro-oncogenic function in osteosarcoma. Wang Y, et al. J Cell Biochem, 2018 Nov. PMID 29987852
  5. Upregulation of the long non-coding RNA FALEC promotes proliferation and migration of prostate cancer cell lines and predicts prognosis of PCa patients. Zhao R, et al. Prostate, 2017 Jul. PMID 28585762

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CAF-derived exosomal lncRNA FAL1 promotes chemoresistance to oxaliplatin by regulating autophagy in colorectal cancer.
    Title: CAF-derived exosomal lncRNA FAL1 promotes chemoresistance to oxaliplatin by regulating autophagy in colorectal cancer.
  2. Extracellular vesicular lncRNA FAL1 promotes hepatocellular carcinoma cell proliferation and invasion by inducing macrophage M2 polarization.
    Title: Extracellular vesicular lncRNA FAL1 promotes hepatocellular carcinoma cell proliferation and invasion by inducing macrophage M2 polarization.
  3. LncRNA FALEC increases the proliferation, migration and drug resistance of cholangiocarcinoma through competitive regulation of miR-20a-5p/SHOC2 axis.
    Title: LncRNA FALEC increases the proliferation, migration and drug resistance of cholangiocarcinoma through competitive regulation of miR-20a-5p/SHOC2 axis.
  4. LncFALEC recruits ART5/PARP1 and promotes castration-resistant prostate cancer through enhancing PARP1-meditated self PARylation.
    Title: LncFALEC recruits ART5/PARP1 and promotes castration-resistant prostate cancer through enhancing PARP1-meditated self PARylation.
  5. Long non-coding RNA FALEC promotes colorectal cancer progression via regulating miR-2116-3p-targeted PIWIL1.
    Title: Long non-coding RNA FALEC promotes colorectal cancer progression via regulating miR-2116-3p-targeted PIWIL1.
  6. LncRNA FALEC promotes proliferation, migration, and invasion of PTC cells through regulating Wnt/beta-catenin signaling pathway.
    Title: LncRNA FALEC promotes proliferation, migration, and invasion of PTC cells through regulating Wnt/β-catenin signaling pathway.
  7. LncRNA FAL1 promotes the development of oral squamous cell carcinoma through regulating the microRNA-761/CRKL pathway.
    Title: LncRNA FAL1 promotes the development of oral squamous cell carcinoma through regulating the microRNA-761/CRKL pathway.
  8. The focally amplified long non-coding RNA in epithelial cancer (FALEC) was found downregulated in the tissues of tongue squamous cell carcinoma (TSCC) and was predicted to present a good prognosis by bioinformatics analysis. The data revealed that FALEC acted as a tumor suppressor in TSCC and may aid in developing a novel potential therapeutic strategy against TSCC.
    Title: Long noncoding RNA FALEC inhibits proliferation and metastasis of tongue squamous cell carcinoma by epigenetically silencing ECM1 through EZH2.
  9. FALEC is overexpressed in endometrial cancer tissues and cells, and involved in regulating cell proliferation and cell-cycle.
    Title: FALEC exerts oncogenic properties to regulate cell proliferation and cell-cycle in endometrial cancer.
  10. FALEC was a potential molecular marker used to diagnose cervical cancer and evaluate prognosis
    Title: Up-regulation of lncRNA FALEC indicates prognosis and diagnosis values in cervical cancer.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • focally amplified lncRNA on chromosome 1
  • long intergenic non-protein coding RNA 568
  • noncoding RNA-activating 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_051960.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL356356
    Related
    ENST00000718313.1

  2. NR_186305.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL356356
    Related
    ENST00000416894.2

  3. NR_186306.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL356356
    Related
    ENST00000717990.1

  4. NR_186307.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL356356

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    150515752..150536788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    149640590..149661674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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