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UST uronyl 2-sulfotransferase [ Homo sapiens (human) ]

Gene ID: 10090, updated on 14-Nov-2024

Summary

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Official Symbol
USTprovided by HGNC
Official Full Name
uronyl 2-sulfotransferaseprovided by HGNC
Primary source
HGNC:HGNC:17223
See related
Ensembl:ENSG00000111962 MIM:610752; AllianceGenome:HGNC:17223
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
2OST
Summary
Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in thyroid (RPKM 10.7), adrenal (RPKM 4.5) and 21 other tissues See more
Orthologs
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Genomic context

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See UST in Genome Data Viewer
Location:
6q25.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (148747030..149076990)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (149946826..150276839)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (149068166..149398126)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25234 Neighboring gene ribosomal protein SA pseudogene 40 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25235 Neighboring gene uncharacterized LOC124901425 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25237 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17652 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17653 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149069303-149069804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149069805-149070304 Neighboring gene uncharacterized LOC107986659 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:149081854-149082604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25238 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:149090389-149091019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25239 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:149139935-149140821 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:149184983-149185492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17654 Neighboring gene Sharpr-MPRA regulatory region 942 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:149194421-149195620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17655 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:149245080-149245698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149284708-149285284 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:149285285-149285861 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:149290736-149291326 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:149291327-149291917 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:149293308-149294306 Neighboring gene NANOG hESC enhancer GRCh37_chr6:149301302-149301803 Neighboring gene uncharacterized LOC124901424 Neighboring gene UST antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:149335755-149336309 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25240 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:149358711-149359296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25241 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25242 Neighboring gene UST antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25244 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:149394281-149395480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25245 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25246 Neighboring gene Sharpr-MPRA regulatory region 12512 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17656 Neighboring gene small nuclear ribonucleoprotein polypeptide B2 pseudogene Neighboring gene uncharacterized LOC124901426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25247

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of a human uronyl 2-sulfotransferase that sulfates iduronyl and glucuronyl residues in dermatan/chondroitin sulfate. Kobayashi M, et al. J Biol Chem, 1999 Apr 9. PMID 10187838
  2. Recognition of sulfation pattern of chondroitin sulfate by uronosyl 2-O-sulfotransferase. Ohtake S, et al. J Biol Chem, 2005 Nov 25. PMID 16192264
  3. Genome-wide scan of job-related exhaustion with three replication studies implicate a susceptibility variant at the UST gene locus. Sulkava S, et al. Hum Mol Genet, 2013 Aug 15. PMID 23620144, Free PMC Article
  4. Enzyme overexpression - an exercise toward understanding regulation of heparan sulfate biosynthesis. Fang J, et al. Sci Rep, 2016 Aug 11. PMID 27511124, Free PMC Article
  5. Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase. Xu D, et al. J Biol Chem, 2007 Mar 16. PMID 17227754

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that overexpression of 2OST alone in the HEK293 cells did not appreciably affect heparan sulfate (HS) chain length. Also, its simultaneous overexpression with Hsepi abolished the effect of Hsepi overexpression on the HS chain lengh.
    Title: Enzyme overexpression - an exercise toward understanding regulation of heparan sulfate biosynthesis.
  2. Statistical analysis showed the strongest evidence for a variant located in an intron of UST associated with job-related exhaustion.
    Title: Genome-wide scan of job-related exhaustion with three replication studies implicate a susceptibility variant at the UST gene locus.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  4. Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Genome-wide pharmacogenetics of antidepressant response in the GENDEP project.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
  6. 2OST transfers sulfate preferentially to the GlcA residue located in a unique sequence, -GalNAc(4SO(4))-GlcA-GalNAc(6SO(4))-.
    Title: Recognition of sulfation pattern of chondroitin sulfate by uronosyl 2-O-sulfotransferase.
  7. analysis of differences and similarities various residues play in the biological roles of the HS-2OST and CS-2OST enzymes
    Title: Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide pharmacogenetics of antidepressant response in the GENDEP project.
EBI GWAS Catalog
Genome-wide scan of job-related exhaustion with three replication studies implicate a susceptibility variant at the UST gene locus.
EBI GWAS Catalog
Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables [dermatan sulfate]-L-iduronyl 2-Osulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chondroitin 2-O-sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfotransferase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in dermatan sulfate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dermatan sulfate biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
uronyl 2-sulfotransferase
Names
dermatan/chondroitin sulfate 2-sulfotransferase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005715.3 → NP_005706.1  uronyl 2-sulfotransferase

    See identical proteins and their annotated locations for NP_005706.1

    Status: VALIDATED

    Source sequence(s)
    AB020316, AI570697, AL807246, BC093668, CA842761, DB496757
    Consensus CDS
    CCDS5213.1
    UniProtKB/Swiss-Prot
    B2RCX6, Q9Y2C2
    UniProtKB/TrEMBL
    A8KA57
    Related
    ENSP00000356433.4, ENST00000367463.5
    Conserved Domains (1) summary
    cl22970
    Location:104 → 356
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    148747030..149076990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418047.1 → XP_047274003.1  uronyl 2-sulfotransferase isoform X1

  2. XM_047418048.1 → XP_047274004.1  uronyl 2-sulfotransferase isoform X1

  3. XM_011535378.4 → XP_011533680.1  uronyl 2-sulfotransferase isoform X2

    Conserved Domains (1) summary
    cl22970
    Location:104 → 211
    Sulfotransfer_2; Sulfotransferase family

  4. XM_017010152.2 → XP_016865641.1  uronyl 2-sulfotransferase isoform X3

RNA

  1. XR_001743088.3 RNA Sequence

  2. XR_007059195.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    149946826..150276839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353990.1 → XP_054209965.1  uronyl 2-sulfotransferase isoform X1

  2. XM_054353991.1 → XP_054209966.1  uronyl 2-sulfotransferase isoform X2

  3. XM_054353992.1 → XP_054209967.1  uronyl 2-sulfotransferase isoform X3

RNA

  1. XR_008487234.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y2C2.1 GenPept UniProtKB/Swiss-Prot:Q9Y2C2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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