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Hoxa4 homeo box A4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100912525, updated on 2-Nov-2024

Summary

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Official Symbol
Hoxa4provided by RGD
Official Full Name
homeo box A4provided by RGD
Primary source
RGD:2814
See related
EnsemblRapid:ENSRNOG00000027365 AllianceGenome:RGD:2814
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hox1r2; hox1.4
Summary
The protein encoded by this gene is likely a homeobox transcription factor. [provided by RefSeq, Sep 2015]
Expression
Biased expression in Lung (RPKM 23.9), Kidney (RPKM 18.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hoxa4 in Genome Data Viewer
Location:
4q24
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (82620294..82622302, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (81289677..81291685, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (82158234..82160317, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene homeobox A2 Neighboring gene homeobox A3 Neighboring gene homeobox A3 like 1 Neighboring gene uncharacterized LOC120102276 Neighboring gene Hoxa cluster antisense RNA 3 Neighboring gene homeo box A5 Neighboring gene homeobox A6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and expression of rat homeo-box-containing sequences. Falzon M, et al. Gene, 1987. PMID 2886401
  2. Cloning and sequence analysis of homeobox transcription factor cDNAs with an inosine-containing probe. Gorski DH, et al. Biotechniques, 1994 May. PMID 7915120
  3. Cloning of rat homeobox genes. Sakoyama Y, et al. Biochem Genet, 1994 Oct. PMID 7702549
  4. Functional comparison of the Hoxa 4, Hoxa 10, and Hoxa 11 homeoboxes. Zhao Y, et al. Dev Biol, 2002 Apr 1. PMID 11900456
  5. Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed. Horan GS, et al. Genes Dev, 1995 Jul 1. PMID 7628700

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior pattern specification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
homeobox protein Hox-A4
Names
Homeobox gene A4
homeobox A4-like
homeobox protein Hox-A4-like
homeobox protein R2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024350.1 → NP_077326.1  homeobox protein Hox-A4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    E9PT77
    Related
    ENSRNOP00000035732.2, ENSRNOT00000038775.6
    Conserved Domains (1) summary
    pfam00046
    Location:183 → 236
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    82620294..82622302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09635.1 GenPept UniProtKB/Swiss-Prot:P09635

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.