shroom3 shroom family member 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: shroom3provided by ZNC
Official Full Name: shroom family member 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-120817-1
See related: AllianceGenome:ZFIN:ZDB-GENE-120817-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Shr3v1; Shr3v2; Shroom3v1; Shroom3v2
Summary: Predicted to enable actin filament binding activity. Acts upstream of or within podocyte development and posterior lateral line neuromast development. Predicted to be located in cytoplasm and microtubule. Predicted to be active in several cellular components, including adherens junction; apical junction complex; and apical plasma membrane. Is expressed in intestine; otic vesicle; posterior lateral line primordium; pronephros; and spinal cord. Used to study chronic kidney disease. Orthologous to human SHROOM3 (shroom family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (5704393..5787242)
RS_2024_08	current	GRCz11 (GCF_000002035.6)	Unplaced Scaffold	NW_003336762.1 (1440..9220)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (5597476..5680325)
105	previous assembly	GRCz10 (GCF_000002035.5)	Unplaced Scaffold	NW_003336762.1 (1440..9220)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

variants disrupting the actin-binding domain of SHROOM3 may cause podocyte effacement and impairment of the glomerular filtration barrier
Title: Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity.
Shroom3 is required downstream of FGF signalling to mediate proneuromast assembly in zebrafish.
Title: Shroom3 is required downstream of FGF signalling to mediate proneuromast assembly in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within podocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within posterior lateral line neuromast development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in apical junction complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein Shroom3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001278851.1 → NP_001265780.1 protein Shroom3

See identical proteins and their annotated locations for NP_001265780.1

Status: PROVISIONAL

Source sequence(s)

JX455753

UniProtKB/TrEMBL

K7X477

Conserved Domains (2) summary

pfam08687
Location:1320 → 1566

ASD2; Apx/Shroom domain ASD2

pfam08688
Location:646 → 823

ASD1; Apx/Shroom domain ASD1