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TRAP1 TNF receptor associated protein 1 [ Homo sapiens (human) ]

Gene ID: 10131, updated on 10-Dec-2024

Summary

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Official Symbol
TRAP1provided by HGNC
Official Full Name
TNF receptor associated protein 1provided by HGNC
Primary source
HGNC:HGNC:16264
See related
Ensembl:ENSG00000126602 MIM:606219; AllianceGenome:HGNC:16264
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSP75; HSP 75; HSP90L; TRAP-1
Summary
This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in kidney (RPKM 31.7), heart (RPKM 25.6) and 25 other tissues See more
Orthologs
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Genomic context

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See TRAP1 in Genome Data Viewer
Location:
16p13.3
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (3658037..3717524, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3685304..3744794, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3708038..3767525, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3630649-3631444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10329 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3639498-3640244 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10330 Neighboring gene SLX4 structure-specific endonuclease subunit Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10331 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10332 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3690553-3691412 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3691413-3692270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3692271-3693129 Neighboring gene deoxyribonuclease 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3694284-3695037 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3695038-3695790 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3695791-3696544 Neighboring gene uncharacterized LOC124903631 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3704869-3705396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3705397-3705924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3721637-3722136 Neighboring gene uncharacterized LOC124903630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3746221-3746721 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3763763-3764271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7138 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7139 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:3781718-3781878 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3786759-3787446 Neighboring gene CREB binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10333 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10335 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3872073-3872574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3872575-3873074 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:3909888-3910072 Neighboring gene DPPA3 pseudogene 6 Neighboring gene Sharpr-MPRA regulatory region 6998 Neighboring gene Sharpr-MPRA regulatory region 1734 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7140 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7142 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3930393-3930969 Neighboring gene long intergenic non-protein coding RNA 2861

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells. Guzzo G, et al. Oncotarget, 2014 Dec 15. PMID 25564869, Free PMC Article
  2. TRAP1 regulates stemness through Wnt/β-catenin pathway in human colorectal carcinoma. Lettini G, et al. Cell Death Differ, 2016 Nov 1. PMID 27662365, Free PMC Article
  3. 2.4 Å resolution crystal structure of human TRAP1NM, the Hsp90 paralog in the mitochondrial matrix. Sung N, et al. Acta Crystallogr D Struct Biol, 2016 Aug. PMID 27487821, Free PMC Article
  4. TRAP1 regulates cell cycle and apoptosis in thyroid carcinoma cells. Palladino G, et al. Endocr Relat Cancer, 2016 Sep. PMID 27422900
  5. Mitochondrial Hsp90 is a ligand-activated molecular chaperone coupling ATP binding to dimer closure through a coiled-coil intermediate. Sung N, et al. Proc Natl Acad Sci U S A, 2016 Mar 15. PMID 26929380, Free PMC Article

See all (252) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRAP1 drives smooth muscle cell senescence and promotes atherosclerosis via HDAC3-primed histone H4 lysine 12 lactylation.
    Title: TRAP1 drives smooth muscle cell senescence and promotes atherosclerosis via HDAC3-primed histone H4 lysine 12 lactylation.
  2. TRAP1 modulates mitochondrial biogenesis via PGC-1alpha/TFAM signalling pathway in colorectal cancer cells.
    Title: TRAP1 modulates mitochondrial biogenesis via PGC-1α/TFAM signalling pathway in colorectal cancer cells.
  3. Histone chaperone SSRP1 is required for apoptosis inhibition and mitochondrial function in HCC via transcriptional promotion of TRAP1.
    Title: Histone chaperone SSRP1 is required for apoptosis inhibition and mitochondrial function in HCC via transcriptional promotion of TRAP1.
  4. Cytosolic and mitochondrial translation elongation are coordinated through the molecular chaperone TRAP1 for the synthesis and import of mitochondrial proteins.
    Title: Cytosolic and mitochondrial translation elongation are coordinated through the molecular chaperone TRAP1 for the synthesis and import of mitochondrial proteins.
  5. Analysis and functional relevance of the chaperone TRAP-1 interactome in the metabolic regulation and mitochondrial integrity of cancer cells.
    Title: Analysis and functional relevance of the chaperone TRAP-1 interactome in the metabolic regulation and mitochondrial integrity of cancer cells.
  6. The mitochondrial chaperone TRAP-1 regulates the glutamine metabolism in tumor cells.
    Title: The mitochondrial chaperone TRAP-1 regulates the glutamine metabolism in tumor cells.
  7. Metabolic targeting of NRF2 potentiates the efficacy of the TRAP1 inhibitor G-TPP through reduction of ROS detoxification in colorectal cancer.
    Title: Metabolic targeting of NRF2 potentiates the efficacy of the TRAP1 inhibitor G-TPP through reduction of ROS detoxification in colorectal cancer.
  8. TRAP1 Chaperones the Metabolic Switch in Cancer.
    Title: TRAP1 Chaperones the Metabolic Switch in Cancer.
  9. TRAP1 regulates the response of colorectal cancer cells to hypoxia and inhibits ribosome biogenesis under conditions of oxygen deprivation.
    Title: TRAP1 regulates the response of colorectal cancer cells to hypoxia and inhibits ribosome biogenesis under conditions of oxygen deprivation.
  10. HIF1alpha-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia.
    Title: HIF1α-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia.
Submit: New GeneRIF Correction See all GeneRIFs (87)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of TNF receptor-associated protein 1 (TRAP1; HSP90L; HSP75) in Jurkat cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tumor necrosis factor receptor binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chaperone-mediated protein folding TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cellular respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of reactive oxygen species biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational attenuation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HTP PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
heat shock protein 75 kDa, mitochondrial
Names
TNFR-associated protein 1
heat shock protein family C member 5
testicular tissue protein Li 209
tumor necrosis factor type 1 receptor-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033088.1 RefSeqGene

    Range
    5074..64561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272049.2 → NP_001258978.1  heat shock protein 75 kDa, mitochondrial isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AC006111, AK223205, AK299127, DB452880
    Consensus CDS
    CCDS61824.1
    UniProtKB/TrEMBL
    Q53FS6
    Related
    ENSP00000442070.1, ENST00000538171.5
    Conserved Domains (3) summary
    PRK05218
    Location:34 → 649
    PRK05218; heat shock protein 90; Provisional
    pfam00183
    Location:210 → 648
    HSP90; Hsp90 protein
    pfam02518
    Location:60 → 205
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

  2. NM_016292.3 → NP_057376.2  heat shock protein 75 kDa, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_057376.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF154108, BC018950, DB452880
    Consensus CDS
    CCDS10508.1
    UniProtKB/Swiss-Prot
    B4DR68, D3DUC8, F5H897, O43642, O75235, Q12931, Q9UHL5
    UniProtKB/TrEMBL
    A0A140VJY2, Q53FS6
    Related
    ENSP00000246957.5, ENST00000246957.10
    Conserved Domains (1) summary
    PRK05218
    Location:87 → 702
    PRK05218; heat shock protein 90; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    3658037..3717524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522345.3 → XP_011520647.1  heat shock protein 75 kDa, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011520647.1

    UniProtKB/TrEMBL
    I3L0K7
    Related
    ENSP00000458166.1, ENST00000575671.5
    Conserved Domains (3) summary
    PRK05218
    Location:2 → 562
    PRK05218; heat shock protein 90; Provisional
    pfam00183
    Location:123 → 561
    HSP90; Hsp90 protein
    pfam02518
    Location:2 → 118
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    3685304..3744794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379372.1 → XP_054235347.1  heat shock protein 75 kDa, mitochondrial isoform X1

    UniProtKB/TrEMBL
    I3L0K7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12931.3 GenPept UniProtKB/Swiss-Prot:Q12931

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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