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lrrn3a leucine rich repeat neuronal 3a [ Danio rerio (zebrafish) ]

Gene ID: 101887059, updated on 30-Jun-2024

Summary

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Official Symbol
lrrn3aprovided by ZNC
Official Full Name
leucine rich repeat neuronal 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-061220-7
See related
Ensembl:ENSDARG00000077569 AllianceGenome:ZFIN:ZDB-GENE-061220-7
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
lrrn3
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in central nervous system. Used to study schizophrenia. Orthologous to human LRRN3 (leucine rich repeat neuronal 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See lrrn3a in Genome Data Viewer
Location:
chromosome: 25
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (21324597..21344530)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (21226940..21246990)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene fibrinogen-like 2b Neighboring gene transmembrane protein 60 Neighboring gene inner mitochondrial membrane peptidase subunit 2 Neighboring gene uncharacterized LOC110438385 Neighboring gene si:dkey-81e3.2 Neighboring gene dedicator of cytokinesis 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Integrated analyses of zebrafish miRNA and mRNA expression profiles identify miR-29b and miR-223 as potential regulators of optic nerve regeneration. Fuller-Carter PI, et al. BMC Genomics, 2015 Aug 12. PMID 26265132, Free PMC Article
  2. The LRR receptor Islr2 is required for retinal axon routing at the vertebrate optic chiasm. Panza P, et al. Neural Dev, 2015 Oct 22. PMID 26492970, Free PMC Article
  3. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeat neuronal protein 3
Names
leucine rich repeat neuronal 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    21324597..21344530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163071.4 → XP_005163128.1  leucine-rich repeat neuronal protein 3

    UniProtKB/TrEMBL
    A0A140LFQ4, A0A8M2BA82
    Related
    ENSDARP00000142078.1, ENSDART00000151842.3
    Conserved Domains (8) summary
    smart00082
    Location:368 → 412
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:429 → 513
    IG_like; Immunoglobulin like
    cd00063
    Location:526 → 591
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00116
    Location:29 → 272
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:336 → 359
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:94 → 117
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:140 → 200
    LRR_8; Leucine rich repeat
    cl11960
    Location:437 → 513
    Ig; Immunoglobulin domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395200.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    141839..162163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021473860.1 → XP_021329535.1  leucine-rich repeat neuronal protein 3

    UniProtKB/TrEMBL
    A0A8M9Q8D1
    Conserved Domains (7) summary
    smart00082
    Location:368 → 412
    LRRCT; Leucine rich repeat C-terminal domain
    cd00063
    Location:526 → 591
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    sd00031
    Location:336 → 359
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:94 → 117
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:140 → 200
    LRR_8; Leucine rich repeat
    cl11960
    Location:437 → 513
    Ig; Immunoglobulin domain
    cl26018
    Location:28 → 324
    NEL; C-terminal novel E3 ligase, LRR-interacting
Nucleotide Protein
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