radil2a Ras association and DIL domains 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: radil2aprovided by ZNC
Official Full Name: Ras association and DIL domains 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-130530-682
See related: Ensembl:ENSDARG00000059567 AllianceGenome:ZFIN:ZDB-GENE-130530-682
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: radil-b; zmp:0000000679; si:ch73-281f12.4
Summary: Predicted to enable GTPase binding activity. Predicted to be involved in neural crest cell migration and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within cell adhesion and signal transduction. Predicted to be active in microtubule. Orthologous to human RASIP1 (Ras interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (58712682..58798810, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (58655908..58739070, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Ras-associating and dilute domain-containing protein-like; ras-associating and dilute domain-containing protein-like

Names: Ras-associated forkhead-associated dilute domain protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001285388.2 → NP_001272317.2 Ras-associating and dilute domain-containing protein-like

Status: VALIDATED

Source sequence(s)

CU570691, CU651584

UniProtKB/TrEMBL

A0A0R4IFD5, A0A8M1P667, J9PK17

Related

ENSDARP00000133527.1, ENSDART00000161248.2

Conserved Domains (4) summary

cd00060
Location:329 → 441

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd00992
Location:1045 → 1129

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15472
Location:501 → 865

Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1

pfam00788
Location:115 → 214

RA; Ras association (RalGDS/AF-6) domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

58712682..58798810 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021469262.2 → XP_021324937.1 ras-associating and dilute domain-containing protein-like isoform X1

UniProtKB/TrEMBL

A0A8M9P454, J9PK17

Conserved Domains (4) summary

cd00060
Location:329 → 441

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd00992
Location:1044 → 1128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd15472
Location:501 → 865

Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1

pfam00788
Location:115 → 214

RA; Ras association (RalGDS/AF-6) domain