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Slc22a13 solute carrier family 22 (organic cation transporter), member 13 [ Mus musculus (house mouse) ]

Gene ID: 102570, updated on 12-May-2024

Summary

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Official Symbol
Slc22a13provided by MGI
Official Full Name
solute carrier family 22 (organic cation transporter), member 13provided by MGI
Primary source
MGI:MGI:2143107
See related
Ensembl:ENSMUSG00000074028 AllianceGenome:MGI:2143107
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OAT10; OCTL1; OCTL3; ORCTL3
Summary
Predicted to enable nicotinate transmembrane transporter activity. Involved in negative regulation of fatty acid metabolic process. Predicted to be located in Golgi apparatus; apical plasma membrane; and endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SLC22A13 (solute carrier family 22 member 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward kidney adult (RPKM 69.2) See more
Orthologs
human all
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Genomic context

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See Slc22a13 in Genome Data Viewer
Location:
9 F3; 9 71.33 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (119020618..119038171, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (119192966..119209105, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide pseudogene Neighboring gene solute carrier family 22 (organic cation transporter), member 14 Neighboring gene STARR-seq mESC enhancer starr_25468 Neighboring gene STARR-seq mESC enhancer starr_25469 Neighboring gene solute carrier family 22 (organic cation transporter), member 13b Neighboring gene oxidative-stress responsive 1 Neighboring gene STARR-positive B cell enhancer ABC_E1119 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:119231914-119232305

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional characterization of human organic anion transporter 10 (OAT10/SLC22A13) as an orotate transporter. Shinoda Y, et al. Drug Metab Pharmacokinet, 2022 Apr. PMID 35144162
  2. The anticancer gene ORCTL3 targets stearoyl-CoA desaturase-1 for tumour-specific apoptosis. AbuAli G, et al. Oncogene, 2015 Mar 26. PMID 24769897, Free PMC Article
  3. An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo. Man JCK, et al. Nat Commun, 2019 Oct 30. PMID 31666509, Free PMC Article
  4. The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. Willnow T, et al. Organogenesis, 2005 Apr. PMID 19521566, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nicotinate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nicotinate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables urate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of fatty acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nicotinate transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nicotinate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell mediated cytotoxicity directed against tumor cell target ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in urate transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
solute carrier family 22 member 13
Names
ORCTL-3
organic anion transporter 10
organic cation transporter-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133980.3 → NP_598741.2  solute carrier family 22 member 13

    See identical proteins and their annotated locations for NP_598741.2

    Status: VALIDATED

    Source sequence(s)
    AC055818, AF529220, AI649135
    Consensus CDS
    CCDS40802.1
    UniProtKB/Swiss-Prot
    E9QP74, Q6A4L0, Q8VC89
    Related
    ENSMUSP00000081855.5, ENSMUST00000084797.6
    Conserved Domains (2) summary
    cd06174
    Location:139 → 500
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:12 → 510
    2A0119; cation transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    119020618..119038171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511917.4 → XP_006511980.1  solute carrier family 22 member 13 isoform X1

    Conserved Domains (1) summary
    cl28910
    Location:1 → 356
    MFS; Major Facilitator Superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6A4L0.3 GenPept UniProtKB/Swiss-Prot:Q6A4L0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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