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Ndufb1 NADH:ubiquinone oxidoreductase subunit B1 [ Mus musculus (house mouse) ]

Gene ID: 102631912, updated on 18-Nov-2024

Summary

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Official Symbol
Ndufb1provided by MGI
Official Full Name
NADH:ubiquinone oxidoreductase subunit B1provided by MGI
Primary source
MGI:MGI:3780865
See related
Ensembl:ENSMUSG00000113902 AllianceGenome:MGI:3780865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm2695; CI-MNLL; 100040297; Ndufb1-ps
Summary
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial inner membrane and nuclear speck. Predicted to be part of respiratory chain complex I. Orthologous to human NDUFB1 (NADH:ubiquinone oxidoreductase subunit B1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart adult (RPKM 23.3), bladder adult (RPKM 22.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ndufb1 in Genome Data Viewer
Location:
12 E; 12 51.33 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (101934355..101941997, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (101968096..101975738, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor interactor 11 Neighboring gene predicted gene, 20036 Neighboring gene STARR-positive B cell enhancer ABC_E1452 Neighboring gene ataxin 3 Neighboring gene STARR-seq mESC enhancer starr_33093 Neighboring gene cleavage and polyadenylation specific factor 2 Neighboring gene solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 Neighboring gene U3B small nuclear RNA pseudogene 3 Neighboring gene predicted gene, 25203 Neighboring gene Ras and Rab interactor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SCAF1 drives the compositional diversity of mammalian respirasomes. Vercellino I, et al. Nat Struct Mol Biol, 2024 Jul. PMID 38575788
  2. Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. Signes A, et al. Essays Biochem, 2018 Jul 20. PMID 30030361, Free PMC Article
  3. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in aerobic respiration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
  
part_of respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
nADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
Names
Complex I-MNLL
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
NADH-ubiquinone oxidoreductase MNLL subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378525.1 → NP_001365454.1  nADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

    Status: VALIDATED

    Source sequence(s)
    AA450698, AI646380
    UniProtKB/Swiss-Prot
    P0DN34
    Related
    ENSMUSP00000159138.2, ENSMUST00000221422.2
    Conserved Domains (1) summary
    pfam08040
    Location:1 → 57
    NADH_oxidored; MNLL subunit

  2. NM_001378527.1 → NP_001365456.1  nADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

    Status: VALIDATED

    Source sequence(s)
    AI646380, BX525811
    UniProtKB/Swiss-Prot
    P0DN34
    Related
    ENSMUSP00000159028.2, ENSMUST00000221191.2
    Conserved Domains (1) summary
    pfam08040
    Location:1 → 57
    NADH_oxidored; MNLL subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    101934355..101941997 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DN34.1 GenPept UniProtKB/Swiss-Prot:P0DN34

Gene LinkOut

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