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CSAG2 CSAG family member 2 [ Homo sapiens (human) ]

Gene ID: 102723547, updated on 2-Nov-2024

Summary

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Official Symbol
CSAG2provided by HGNC
Official Full Name
CSAG family member 2provided by HGNC
Primary source
HGNC:HGNC:16847
See related
Ensembl:ENSG00000268902 MIM:301096; AllianceGenome:HGNC:16847
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRAG3; CSAG3B; CT24.2; TRAG-3
Summary
Predicted to be involved in response to xenobiotic stimulus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis (RPKM 1.0), lymph node (RPKM 0.8) and 5 other tissues See more
Orthologs
all
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Genomic context

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See CSAG2 in Genome Data Viewer
Location:
Xq28
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (152708261..152709391, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (150974834..150975846, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (151876743..151877755, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MAGEA3 divergent transcript Neighboring gene MAGE family member A4 pseudogene Neighboring gene uncharacterized LOC124905224 Neighboring gene MAGE family member A3 Neighboring gene MAGE family member A2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Upregulation of TRAG3 gene in urothelial carcinoma of the bladder. Karam JA, et al. Int J Cancer, 2011 Jun 15. PMID 20734393, Free PMC Article
  2. TRAG-3, a novel gene, isolated from a taxol-resistant ovarian carcinoma cell line. Duan Z, et al. Gene, 1999 Mar 18. PMID 10095106
  3. TRAG-3, a novel cancer/testis antigen, is overexpressed in the majority of melanoma cell lines and malignant melanoma. Feller AJ, et al. Anticancer Res, 2000 Nov-Dec. PMID 11205240
  4. Cancer/testis antigen CSAGE is concurrently expressed with MAGE in chondrosarcoma. Lin C, et al. Gene, 2002 Feb 20. PMID 12039054
  5. Expression of TRAG-3 antigen in non-small-cell lung carcinomas. Chen Z, et al. Lung Cancer, 2002 Oct. PMID 12367802

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CSAG2 is a cancer-specific activator of SIRT1.
    Title: CSAG2 is a cancer-specific activator of SIRT1.
  2. DNA demethylation is an important epigenetic mechanism that regulates the TRAG-3 tumor antigen in human tumors
    Title: Epigenetic regulation of the taxol resistance-associated gene TRAG-3 in human tumors.
  3. TRAG3 was significantly higher in T24-L and T24-B than T24-P. TRAG3 gene expression is likely controlled by DNA methylation but not histone acetylation
    Title: Upregulation of TRAG3 gene in urothelial carcinoma of the bladder.
  4. Human VCX/Y, SPANX, and CSAG2 gene families together with the murine SPANX gene and the CYPT family may share a common ancestor.
    Title: A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family.
  5. As the TRAG-3 gene is located on Xq28, which is the same locus as the MAGE gene family, we found a frequent synchronous expression pattern with TRAG-3 and MAGE-3 in esophageal cancer.
    Title: Expression of the TRAG-3 gene in human esophageal cancer: the frequent synchronous expression of MAGE-3 gene.
  6. TRAG-3-specific CD4+ T cells recognize in vitro not only peptide pulsed antigen presenting cells but also autologous dendritic cells loaded with the TRAG-3 protein.
    Title: Spontaneous CD4+ T cell responses against TRAG-3 in patients with melanoma and breast cancers.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

Clone Names

  • MGC149851, MGC149852

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in response to xenobiotic stimulus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
chondrosarcoma-associated gene 2/3 protein
Names
CSAG family, member 3B
cancer/testis antigen 24.2
cancer/testis antigen family 24, member 2
chondrosarcoma-associated gene 2/3 protein-like
taxol resistance associated gene 3
taxol-resistant-associated gene 3 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395334.1 → NP_001382263.1  chondrosarcoma-associated gene 2/3 protein

    Status: VALIDATED

    Source sequence(s)
    AC244102
    Consensus CDS
    CCDS94689.1
    UniProtKB/TrEMBL
    A0A1W2PPV0
    Related
    ENSP00000491733.1, ENST00000638741.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    152708261..152709391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017030023.1 → XP_016885512.1  chondrosarcoma-associated gene 2/3 protein isoform X1

    UniProtKB/TrEMBL
    A0A1W2PQG5
    Related
    ENSP00000491720.1, ENST00000640702.1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791818.1 Reference GRCh38.p14 PATCHES

    Range
    369072..375384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333331.1 → XP_054189306.1  chondrosarcoma-associated gene 2/3 protein isoform X2

    UniProtKB/Swiss-Prot
    O75605, Q0VDC3, Q96IU8, Q9Y5P2

  2. XM_054333332.1 → XP_054189307.1  chondrosarcoma-associated gene 2/3 protein isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    150974834..150975846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y5P2.2 GenPept UniProtKB/Swiss-Prot:Q9Y5P2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials