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rasip1 Ras interacting protein 1 [ Danio rerio (zebrafish) ]

Gene ID: 102725533, updated on 10-Mar-2024

Summary

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Official Symbol
rasip1provided by ZNC
Official Full Name
Ras interacting protein 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-120403-3
See related
Ensembl:ENSDARG00000074829 AllianceGenome:ZFIN:ZDB-GENE-120403-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable GTPase binding activity. Acts upstream of or within vasculature development. Predicted to be active in cell-cell junction. Is expressed in dorsal aorta; intersegmental vessel; and posterior cardinal vein. Orthologous to human RASIP1 (Ras interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See rasip1 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (12517471..12560723)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (12626552..12670729)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 member 3b Neighboring gene cytochrome c oxidase subunit 6B2 Neighboring gene interleukin 11a Neighboring gene zinc finger protein 628

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling. Wilson CW, et al. Blood, 2013 Nov 21. PMID 23886837, Free PMC Article
  2. Control of dynamic cell behaviors during angiogenesis and anastomosis by Rasip1. Lee M, et al. Development, 2021 Aug 1. PMID 34383884, Free PMC Article
  3. Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Chestnut B, et al. Dev Dyn, 2020 Feb. PMID 31705559, Free PMC Article
  4. Identification of vascular and hematopoietic genes downstream of etsrp by deep sequencing in zebrafish. Gomez G, et al. PLoS One, 2012. PMID 22438865, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell-cell junction organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Rho-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vasculature development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289880.1 → NP_001276809.1  ras-interacting protein 1

    See identical proteins and their annotated locations for NP_001276809.1

    Status: PROVISIONAL

    Source sequence(s)
    JF519850
    UniProtKB/TrEMBL
    J9PJE8
    Related
    ENSDARP00000097515.4, ENSDART00000114411.4
    Conserved Domains (2) summary
    cd15472
    Location:568 → 945
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    cl00155
    Location:139 → 254
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    12517471..12560723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001921544.7 → XP_001921579.4  ras-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M1QKL7, E7F6P4, X1WD31
    Related
    ENSDARP00000128128.1, ENSDART00000155407.3
    Conserved Domains (2) summary
    cd15472
    Location:568 → 945
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    cl00155
    Location:139 → 254
    UBQ; Ubiquitin-like proteins
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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