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Cep57l1 centrosomal protein 57-like 1 [ Mus musculus (house mouse) ]

Gene ID: 103268, updated on 9-Dec-2024

Summary

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Official Symbol
Cep57l1provided by MGI
Official Full Name
centrosomal protein 57-like 1provided by MGI
Primary source
MGI:MGI:1915511
See related
Ensembl:ENSMUSG00000019813 AllianceGenome:MGI:1915511
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
cep57R; 2410017P07Rik; 4930484D11Rik
Summary
Predicted to enable identical protein binding activity and microtubule binding activity. Predicted to be located in cytoplasm and microtubule. Predicted to be active in centrosome. Is expressed in adrenal gland; ovary; and testis. Orthologous to human CEP57L1 (centrosomal protein 57 like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in testis adult (RPKM 5.8), CNS E11.5 (RPKM 4.2) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Cep57l1 in Genome Data Viewer
Location:
10 B2; 10 22.69 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (41594836..41686413, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (41718840..41809868, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5730435O14 gene Neighboring gene coiled-coil domain containing 162 Neighboring gene STARR-positive B cell enhancer mm9_chr10:41292844-41293145 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:41339920-41340109 Neighboring gene STARR-positive B cell enhancer ABC_E5128 Neighboring gene microRNA 3473b Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:41472075-41472184 Neighboring gene cDNA sequence BC048559 Neighboring gene STARR-seq mESC enhancer starr_26466 Neighboring gene STARR-seq mESC enhancer starr_26467 Neighboring gene STARR-seq mESC enhancer starr_26468 Neighboring gene STARR-seq mESC enhancer starr_26469 Neighboring gene sestrin 1 Neighboring gene STARR-seq mESC enhancer starr_26471 Neighboring gene armadillo repeat containing 2 Neighboring gene annexin A2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
  2. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
  3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables gamma-tubulin binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
centrosomal protein CEP57L1
Names
centrosomal protein 57kDa-like protein 1
centrosomal protein of 57 kDa-related protein
cep57-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243074.1 → NP_001230003.1  centrosomal protein CEP57L1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 1. It initiates translation at an alternate upstream start codon. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC115297, AC161426, AK010530, AK012710
    UniProtKB/Swiss-Prot
    Q8VDS7, Q9CZE0, Q9D5A1
    Conserved Domains (2) summary
    pfam06657
    Location:281 → 352
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:76 → 241
    Cep57_CLD; Centrosome localization domain of Cep57

  2. NM_001243075.1 → NP_001230004.1  centrosomal protein CEP57L1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 1. It initiates translation at an alternate upstream start codon. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC115297, AC161426, AK010530, AK012710
    UniProtKB/TrEMBL
    A0A0R4J2C9
    Related
    ENSMUSP00000141031.2, ENSMUST00000190022.7
    Conserved Domains (2) summary
    pfam06657
    Location:234 → 305
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:76 → 177
    Cep57_CLD; Centrosome localization domain of Cep57

  3. NM_026643.6 → NP_080919.3  centrosomal protein CEP57L1 isoform 2

    See identical proteins and their annotated locations for NP_080919.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC115297, AC161426, AK010530
    Consensus CDS
    CCDS23808.1
    UniProtKB/Swiss-Prot
    Q8VDS7, Q9CZE0, Q9D5A1
    UniProtKB/TrEMBL
    B2RR53
    Related
    ENSMUSP00000140389.2, ENSMUST00000187143.7
    Conserved Domains (2) summary
    pfam06657
    Location:254 → 327
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:50 → 215
    Cep57_CLD; Centrosome localization domain of Cep57

  4. NM_029132.2 → NP_083408.1  centrosomal protein CEP57L1 isoform 1

    See identical proteins and their annotated locations for NP_083408.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC115297, AC161426, AK010530
    Consensus CDS
    CCDS48549.1
    UniProtKB/Swiss-Prot
    Q8VDS7, Q9CZE0, Q9D5A1
    UniProtKB/TrEMBL
    G5E828
    Related
    ENSMUSP00000139509.2, ENSMUST00000186239.7
    Conserved Domains (2) summary
    pfam06657
    Location:283 → 356
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:50 → 227
    Cep57_CLD; Centrosome localization domain of Cep57

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    41594836..41686413 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155463.1 → XP_036011356.1  centrosomal protein CEP57L1 isoform X6

    UniProtKB/Swiss-Prot
    Q8VDS7, Q9CZE0, Q9D5A1
    Conserved Domains (2) summary
    pfam06657
    Location:299 → 372
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:66 → 243
    Cep57_CLD; Centrosome localization domain of Cep57

  2. XM_036155471.1 → XP_036011364.1  centrosomal protein CEP57L1 isoform X11

    UniProtKB/Swiss-Prot
    Q8VDS7, Q9CZE0, Q9D5A1
    Conserved Domains (2) summary
    pfam06657
    Location:270 → 343
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:66 → 231
    Cep57_CLD; Centrosome localization domain of Cep57

  3. XM_036155469.1 → XP_036011362.1  centrosomal protein CEP57L1 isoform X10

    UniProtKB/Swiss-Prot
    Q8VDS7, Q9CZE0, Q9D5A1
    UniProtKB/TrEMBL
    G5E828
    Conserved Domains (2) summary
    pfam06657
    Location:283 → 356
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:50 → 227
    Cep57_CLD; Centrosome localization domain of Cep57

  4. XM_036155479.1 → XP_036011372.1  centrosomal protein CEP57L1 isoform X16

    Conserved Domains (1) summary
    pfam14073
    Location:76 → 254
    Cep57_CLD; Centrosome localization domain of Cep57

  5. XM_036155460.1 → XP_036011353.1  centrosomal protein CEP57L1 isoform X3

    UniProtKB/Swiss-Prot
    Q8VDS7, Q9CZE0, Q9D5A1
    Conserved Domains (2) summary
    pfam06657
    Location:309 → 382
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:76 → 253
    Cep57_CLD; Centrosome localization domain of Cep57

  6. XM_036155480.1 → XP_036011373.1  centrosomal protein CEP57L1 isoform X17

    Conserved Domains (2) summary
    pfam06657
    Location:158 → 231
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:26 → 102
    Cep57_CLD; Centrosome localization domain of Cep57

  7. XM_036155473.1 → XP_036011366.1  centrosomal protein CEP57L1 isoform X13

    UniProtKB/Swiss-Prot
    Q8VDS7, Q9CZE0, Q9D5A1
    Conserved Domains (2) summary
    pfam06657
    Location:264 → 337
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:76 → 225
    Cep57_CLD; Centrosome localization domain of Cep57

  8. XM_036155464.1 → XP_036011357.1  centrosomal protein CEP57L1 isoform X7

    UniProtKB/Swiss-Prot
    Q8VDS7, Q9CZE0, Q9D5A1
    Conserved Domains (2) summary
    pfam06657
    Location:293 → 366
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:76 → 237
    Cep57_CLD; Centrosome localization domain of Cep57

  9. XM_036155481.1 → XP_036011374.1  centrosomal protein CEP57L1 isoform X18

    Conserved Domains (2) summary
    pfam06657
    Location:129 → 202
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:26 → 90
    Cep57_CLD; Centrosome localization domain of Cep57

  10. XM_036155472.1 → XP_036011365.1  centrosomal protein CEP57L1 isoform X12

    UniProtKB/Swiss-Prot
    Q8VDS7, Q9CZE0, Q9D5A1
    Conserved Domains (2) summary
    pfam06657
    Location:267 → 340
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:50 → 211
    Cep57_CLD; Centrosome localization domain of Cep57

  11. XM_036155474.1 → XP_036011367.1  centrosomal protein CEP57L1 isoform X14

    UniProtKB/Swiss-Prot
    Q8VDS7, Q9CZE0, Q9D5A1
    UniProtKB/TrEMBL
    B2RR53
    Related
    ENSMUSP00000140147.2, ENSMUST00000189770.7
    Conserved Domains (2) summary
    pfam06657
    Location:254 → 327
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:50 → 215
    Cep57_CLD; Centrosome localization domain of Cep57

  12. XM_036155482.1 → XP_036011375.1  centrosomal protein CEP57L1 isoform X19

    Conserved Domains (2) summary
    pfam06657
    Location:122 → 195
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:1 → 66
    Cep57_CLD; Centrosome localization domain of Cep57

  13. XM_036155467.1 → XP_036011360.1  centrosomal protein CEP57L1 isoform X10

    UniProtKB/Swiss-Prot
    Q8VDS7, Q9CZE0, Q9D5A1
    UniProtKB/TrEMBL
    G5E828
    Conserved Domains (2) summary
    pfam06657
    Location:283 → 356
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:50 → 227
    Cep57_CLD; Centrosome localization domain of Cep57

  14. XM_036155462.1 → XP_036011355.1  centrosomal protein CEP57L1 isoform X5

    UniProtKB/Swiss-Prot
    Q8VDS7, Q9CZE0, Q9D5A1
    Conserved Domains (2) summary
    pfam06657
    Location:301 → 374
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:68 → 245
    Cep57_CLD; Centrosome localization domain of Cep57

  15. XM_036155470.1 → XP_036011363.1  centrosomal protein CEP57L1 isoform X10

    UniProtKB/Swiss-Prot
    Q8VDS7, Q9CZE0, Q9D5A1
    UniProtKB/TrEMBL
    G5E828
    Conserved Domains (2) summary
    pfam06657
    Location:283 → 356
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:50 → 227
    Cep57_CLD; Centrosome localization domain of Cep57

  16. XM_036155468.1 → XP_036011361.1  centrosomal protein CEP57L1 isoform X10

    UniProtKB/Swiss-Prot
    Q8VDS7, Q9CZE0, Q9D5A1
    UniProtKB/TrEMBL
    G5E828
    Conserved Domains (2) summary
    pfam06657
    Location:283 → 356
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:50 → 227
    Cep57_CLD; Centrosome localization domain of Cep57

  17. XM_036155476.1 → XP_036011369.1  centrosomal protein CEP57L1 isoform X12

    UniProtKB/Swiss-Prot
    Q8VDS7, Q9CZE0, Q9D5A1
    Conserved Domains (2) summary
    pfam06657
    Location:267 → 340
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:50 → 211
    Cep57_CLD; Centrosome localization domain of Cep57

  18. XM_036155478.1 → XP_036011371.1  centrosomal protein CEP57L1 isoform X15

    Conserved Domains (1) summary
    pfam14073
    Location:102 → 280
    Cep57_CLD; Centrosome localization domain of Cep57

  19. XM_036155459.1 → XP_036011352.1  centrosomal protein CEP57L1 isoform X2

    UniProtKB/Swiss-Prot
    Q8VDS7, Q9CZE0, Q9D5A1
    Conserved Domains (2) summary
    pfam06657
    Location:319 → 392
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:102 → 263
    Cep57_CLD; Centrosome localization domain of Cep57

  20. XM_036155466.1 → XP_036011359.1  centrosomal protein CEP57L1 isoform X9

    UniProtKB/Swiss-Prot
    Q8VDS7, Q9CZE0, Q9D5A1
    Conserved Domains (2) summary
    pfam06657
    Location:290 → 363
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:102 → 251
    Cep57_CLD; Centrosome localization domain of Cep57

  21. XM_036155458.1 → XP_036011351.1  centrosomal protein CEP57L1 isoform X1

    UniProtKB/Swiss-Prot
    Q8VDS7, Q9CZE0, Q9D5A1
    Conserved Domains (2) summary
    pfam06657
    Location:335 → 408
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:102 → 279
    Cep57_CLD; Centrosome localization domain of Cep57

  22. XM_036155461.1 → XP_036011354.1  centrosomal protein CEP57L1 isoform X4

    UniProtKB/Swiss-Prot
    Q8VDS7, Q9CZE0, Q9D5A1
    Conserved Domains (2) summary
    pfam06657
    Location:306 → 379
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:102 → 267
    Cep57_CLD; Centrosome localization domain of Cep57

  23. XM_036155477.1 → XP_036011370.1  centrosomal protein CEP57L1 isoform X14

    UniProtKB/Swiss-Prot
    Q8VDS7, Q9CZE0, Q9D5A1
    UniProtKB/TrEMBL
    B2RR53
    Related
    ENSMUSP00000101144.4, ENSMUST00000105505.10
    Conserved Domains (2) summary
    pfam06657
    Location:254 → 327
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:50 → 215
    Cep57_CLD; Centrosome localization domain of Cep57

  24. XM_036155475.1 → XP_036011368.1  centrosomal protein CEP57L1 isoform X10

    UniProtKB/Swiss-Prot
    Q8VDS7, Q9CZE0, Q9D5A1
    UniProtKB/TrEMBL
    G5E828
    Conserved Domains (2) summary
    pfam06657
    Location:283 → 356
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:50 → 227
    Cep57_CLD; Centrosome localization domain of Cep57

  25. XM_036155465.1 → XP_036011358.1  centrosomal protein CEP57L1 isoform X8

    UniProtKB/Swiss-Prot
    Q8VDS7, Q9CZE0, Q9D5A1
    Conserved Domains (2) summary
    pfam06657
    Location:292 → 365
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:59 → 236
    Cep57_CLD; Centrosome localization domain of Cep57

  26. XM_036155483.1 → XP_036011376.1  centrosomal protein CEP57L1 isoform X19

    Conserved Domains (2) summary
    pfam06657
    Location:122 → 195
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:1 → 66
    Cep57_CLD; Centrosome localization domain of Cep57
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDS7.1 GenPept UniProtKB/Swiss-Prot:Q8VDS7

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