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Xpo1 exportin 1 [ Mus musculus (house mouse) ]

Gene ID: 103573, updated on 9-Aug-2024

Summary

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Official Symbol
Xpo1provided by MGI
Official Full Name
exportin 1provided by MGI
Primary source
MGI:MGI:2144013
See related
Ensembl:ENSMUSG00000020290 AllianceGenome:MGI:2144013
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crm1; Exp1
Summary
Enables nuclear export signal receptor activity. Acts upstream of or within several processes, including protein export from nucleus; regulation of centrosome duplication; and regulation of protein export from nucleus. Located in nucleus. Is expressed in several structures, including alimentary system; early embryo; nervous system; respiratory system; and sensory organ. Orthologous to human XPO1 (exportin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 31.7), limb E14.5 (RPKM 25.4) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Xpo1 in Genome Data Viewer
Location:
11 A3.2; 11 14.28 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (23205768..23248250)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (23255909..23297597)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700061J23 gene Neighboring gene STARR-seq mESC enhancer starr_28906 Neighboring gene predicted gene, 24398 Neighboring gene STARR-seq mESC enhancer starr_28907 Neighboring gene STARR-seq mESC enhancer starr_28908 Neighboring gene STARR-positive B cell enhancer ABC_E729 Neighboring gene ubiquitin specific peptidase 34 Neighboring gene STARR-seq mESC enhancer starr_28911 Neighboring gene RIKEN cDNA 1700030C12 gene Neighboring gene STARR-positive B cell enhancer ABC_E9818 Neighboring gene predicted gene, 22753 Neighboring gene AHA1, activator of heat shock protein ATPase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prolonged XPO1 inhibition is essential for optimal antileukemic activity in NPM1-mutated AML. Pianigiani G, et al. Blood Adv, 2022 Nov 22. PMID 36037515, Free PMC Article
  2. Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain. Gorostieta-Salas E, et al. Oxid Med Cell Longev, 2021. PMID 34434486, Free PMC Article
  3. Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells. Olazagoitia-Garmendia A, et al. Gut, 2022 Jan. PMID 33526437, Free PMC Article
  4. Structural basis for cooperativity of CRM1 export complex formation. Monecke T, et al. Proc Natl Acad Sci U S A, 2013 Jan 15. PMID 23277578, Free PMC Article
  5. Abundance of the largest subunit of RNA polymerase II in the nucleus is regulated by nucleo-cytoplasmic shuttling. Custódio N, et al. Exp Cell Res, 2006 Aug 1. PMID 16765347

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differential impact of exportin-1-mediated nuclear export of RNAs on the RNA content of extracellular vesicle subpopulations.
    Title: Differential impact of exportin-1-mediated nuclear export of RNAs on the RNA content of extracellular vesicle subpopulations.
  2. Prolonged XPO1 inhibition is essential for optimal antileukemic activity in NPM1-mutated AML.
    Title: Prolonged XPO1 inhibition is essential for optimal antileukemic activity in NPM1-mutated AML.
  3. Hydrocortisone alleviates sepsis-induced acute kidney injury through HSF-1-mediated transcriptional suppression of XPO1.
    Title: Hydrocortisone alleviates sepsis-induced acute kidney injury through HSF-1-mediated transcriptional suppression of XPO1.
  4. Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain.
    Title: Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain.
  5. Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells.
    Title: Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells.
  6. Inhibition of Autism-Related Crm1 Disrupts Mitosis and Induces Apoptosis of the Cortical Neural Progenitors.
    Title: Inhibition of Autism-Related Crm1 Disrupts Mitosis and Induces Apoptosis of the Cortical Neural Progenitors.
  7. Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
    Title: Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
  8. NXF1 and CRM1 nuclear export pathways orchestrate nuclear export, translation and packaging of murine leukaemia retrovirus unspliced RNA.
    Title: NXF1 and CRM1 nuclear export pathways orchestrate nuclear export, translation and packaging of murine leukaemia retrovirus unspliced RNA.
  9. myeloid transformation requires the interaction of XPO1 with SETBP1
    Title: Interaction with XPO1 is essential for SETBP1 to induce myeloid transformation.
  10. Combinatorial targeting of XPO1 and FLT3 exerts synergistic anti-leukemia effects through induction of differentiation and apoptosis in FLT3-mutated acute myeloid leukemias.
    Title: Combinatorial targeting of XPO1 and FLT3 exerts synergistic anti-leukemia effects through induction of differentiation and apoptosis in FLT3-mutated acute myeloid leukemias: from concept to clinical trial.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear export signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear export signal receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear export signal receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nuclear export signal receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA export from nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleocytoplasmic transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein export from nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein export from nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein export from nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of centrosome duplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal subunit export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome biogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in annulate lamellae ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
exportin-1
Names
chromosome region maintenance 1 protein homolog
exportin 1, CRM1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035226.1 → NP_001030303.1  exportin-1

    See identical proteins and their annotated locations for NP_001030303.1

    Status: VALIDATED

    Source sequence(s)
    AK037196, BC062912
    Consensus CDS
    CCDS24475.1
    UniProtKB/Swiss-Prot
    Q6P5F9
    Related
    ENSMUSP00000099934.2, ENSMUST00000102870.8
    Conserved Domains (1) summary
    COG5101
    Location:15 → 1044
    CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

  2. NM_001412406.1 → NP_001399335.1  exportin-1

    Status: VALIDATED

    Source sequence(s)
    AL772359
    UniProtKB/Swiss-Prot
    Q6P5F9

  3. NM_001412407.1 → NP_001399336.1  exportin-1

    Status: VALIDATED

    Source sequence(s)
    AL772359
    UniProtKB/Swiss-Prot
    Q6P5F9
    Related
    ENSMUSP00000099933.2, ENSMUST00000102869.8

  4. NM_001412408.1 → NP_001399337.1  exportin-1

    Status: VALIDATED

    Source sequence(s)
    AL772359
    UniProtKB/Swiss-Prot
    Q6P5F9

  5. NM_134014.3 → NP_598775.2  exportin-1

    See identical proteins and their annotated locations for NP_598775.2

    Status: VALIDATED

    Source sequence(s)
    AK037196, BC062912, CD347786
    Consensus CDS
    CCDS24475.1
    UniProtKB/Swiss-Prot
    Q6P5F9
    Conserved Domains (1) summary
    COG5101
    Location:15 → 1044
    CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    23205768..23248250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314209.3 → XP_017169698.1  exportin-1 isoform X3

    Conserved Domains (1) summary
    COG5101
    Location:1 → 913
    CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

  2. XM_017314208.3 → XP_017169697.1  exportin-1 isoform X2

    Conserved Domains (1) summary
    COG5101
    Location:10 → 978
    CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P5F9.1 GenPept UniProtKB/Swiss-Prot:Q6P5F9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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