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BASP1 brain abundant membrane attached signal protein 1 [ Homo sapiens (human) ]

Gene ID: 10409, updated on 2-Nov-2024

Summary

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Official Symbol
BASP1provided by HGNC
Official Full Name
brain abundant membrane attached signal protein 1provided by HGNC
Primary source
HGNC:HGNC:957
See related
Ensembl:ENSG00000176788 MIM:605940; AllianceGenome:HGNC:957
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAP23; NAP22; CAP-23; NAP-22
Summary
This gene encodes a membrane bound protein with several transient phosphorylation sites and PEST motifs. Conservation of proteins with PEST sequences among different species supports their functional significance. PEST sequences typically occur in proteins with high turnover rates. Immunological characteristics of this protein are species specific. This protein also undergoes N-terminal myristoylation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2012]
Expression
Biased expression in brain (RPKM 144.2), prostate (RPKM 45.3) and 10 other tissues See more
Orthologs
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Genomic context

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See BASP1 in Genome Data Viewer
Location:
5p15.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (17216823..17276834)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (17156199..17216216)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (17216932..17276943)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene BASP1 antisense RNA 1 Neighboring gene uncharacterized LOC105374664 Neighboring gene Sharpr-MPRA regulatory region 6771 Neighboring gene Sharpr-MPRA regulatory region 14227 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15948 Neighboring gene DDB1 and CUL4 associated factor 13 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15950 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:17218860-17219640 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:17227689-17228189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22424 Neighboring gene RNA, U6 small nuclear 1003, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15951 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:17275743-17276243 Neighboring gene BASP1-FTH1P10 intergenic CAGE-defined low expression enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:17311529-17312170 Neighboring gene aurora kinase A interacting protein 1 pseudogene Neighboring gene Sharpr-MPRA regulatory region 14736 Neighboring gene RN7SK pseudogene 133

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. BASP1 is up-regulated in tongue squamous cell carcinoma and associated with a poor prognosis. Li Y, et al. Asian J Surg, 2022 May. PMID 34531104
  2. Cholesterol is required for transcriptional repression by BASP1. Loats AE, et al. Proc Natl Acad Sci U S A, 2021 Jul 20. PMID 34266955, Free PMC Article
  3. The brain acid-soluble protein 1 (BASP1) interferes with the oncogenic capacity of MYC and its binding to calmodulin. Hartl M, et al. Mol Oncol, 2020 Mar. PMID 31944520, Free PMC Article
  4. Sequestration of the abrin A chain to the nucleus by BASP1 increases the resistance of cells to abrin toxicity. Gadadhar S, et al. Biochem J, 2014 Mar 1. PMID 24350992
  5. BASP1 expression is associated with poor prognosis and is correlated with immune infiltration in gastric cancer. Wang T, et al. FEBS Open Bio, 2023 Aug. PMID 37243901, Free PMC Article

See all (121) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Myeloid-specific ablation of Basp1 ameliorates diet-induced NASH in mice by attenuating pro-inflammatory signaling.
    Title: Myeloid-specific ablation of Basp1 ameliorates diet-induced NASH in mice by attenuating pro-inflammatory signaling.
  2. Circ_0008285 silencing suppresses angiotensin II-induced vascular smooth muscle cell apoptosis in thoracic aortic aneurysm via miR-150-5p/BASP1 axis.
    Title: Circ_0008285 silencing suppresses angiotensin II-induced vascular smooth muscle cell apoptosis in thoracic aortic aneurysm via miR-150-5p/BASP1 axis.
  3. BASP1 expression is associated with poor prognosis and is correlated with immune infiltration in gastric cancer.
    Title: BASP1 expression is associated with poor prognosis and is correlated with immune infiltration in gastric cancer.
  4. Downregulation of BASP1 Promotes Temozolomide Resistance in Gliomas via Epigenetic Activation of the FBXO32/NF-kappaB/MGMT Axis.
    Title: Downregulation of BASP1 Promotes Temozolomide Resistance in Gliomas via Epigenetic Activation of the FBXO32/NF-κB/MGMT Axis.
  5. BASP1 promotes high glucose-induced endothelial apoptosis in diabetes via activation of EGFR signaling.
    Title: BASP1 promotes high glucose-induced endothelial apoptosis in diabetes via activation of EGFR signaling.
  6. BASP1 is up-regulated in tongue squamous cell carcinoma and associated with a poor prognosis.
    Title: BASP1 is up-regulated in tongue squamous cell carcinoma and associated with a poor prognosis.
  7. Cholesterol is required for transcriptional repression by BASP1.
    Title: Cholesterol is required for transcriptional repression by BASP1.
  8. Overexpression of BASP1 Indicates a Poor Prognosis in Head and Neck Squamous Cell Carcinoma.
    Title: Overexpression of BASP1 Indicates a Poor Prognosis in Head and Neck Squamous Cell Carcinoma.
  9. Targeting positive feedback between BASP1 and EGFR as a therapeutic strategy for lung cancer progression.
    Title: Targeting positive feedback between BASP1 and EGFR as a therapeutic strategy for lung cancer progression.
  10. The brain acid-soluble protein 1 (BASP1) interferes with the oncogenic capacity of MYC and its binding to calmodulin.
    Title: The brain acid-soluble protein 1 (BASP1) interferes with the oncogenic capacity of MYC and its binding to calmodulin.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association of mood-incongruent psychotic bipolar disorder.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of brain membrane attached signal protein 1 (BASP1) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC8555

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in diaphragm development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in gonad development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mesenchymal to epithelial transition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in metanephric mesenchyme development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in podocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of heart growth ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of metanephric ureteric bud development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein homooligomerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in substantia nigra development HEP PubMed 
involved_in supramolecular fiber organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in thorax and anterior abdomen determination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in PML body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell junction IDA
Inferred from Direct Assay
more info
  
located_in chromatin IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in vesicle HDA PubMed 

General protein information

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Preferred Names
brain acid soluble protein 1
Names
22 kDa neuronal tissue-enriched acidic protein
brain acid-soluble protein 1
neuronal axonal membrane protein NAP-22
neuronal tissue-enriched acidic protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271606.2 → NP_001258535.1  brain acid soluble protein 1

    See identical proteins and their annotated locations for NP_001258535.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC000518, BM973114, BU181147, DA489123, DW458407, HY258599
    Consensus CDS
    CCDS3888.1
    UniProtKB/Swiss-Prot
    B4DJA8, D3DTD5, O43596, P80723, Q5U0S0, Q9BWA5
    Related
    ENSP00000482066.1, ENST00000616743.1
    Conserved Domains (1) summary
    pfam05466
    Location:12 → 227
    BASP1; Brain acid soluble protein 1 (BASP1 protein)

  2. NM_006317.5 → NP_006308.3  brain acid soluble protein 1

    See identical proteins and their annotated locations for NP_006308.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC000518, BM973114, BU181147, CN355202, HY258599
    Consensus CDS
    CCDS3888.1
    UniProtKB/Swiss-Prot
    B4DJA8, D3DTD5, O43596, P80723, Q5U0S0, Q9BWA5
    Related
    ENSP00000319281.3, ENST00000322611.4
    Conserved Domains (1) summary
    pfam05466
    Location:12 → 227
    BASP1; Brain acid soluble protein 1 (BASP1 protein)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    17216823..17276834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    17156199..17216216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P80723.2 GenPept UniProtKB/Swiss-Prot:P80723

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
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