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Tex15 testis expressed gene 15 meiosis and synapsis associated [ Mus musculus (house mouse) ]

Gene ID: 104271, updated on 2-Nov-2024

Summary

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Official Symbol
Tex15provided by MGI
Official Full Name
testis expressed gene 15 meiosis and synapsis associatedprovided by MGI
Primary source
MGI:MGI:1934816
See related
Ensembl:ENSMUSG00000009628 AllianceGenome:MGI:1934816
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2210014E14Rik
Summary
Involved in retrotransposon silencing by piRNA-directed DNA methylation. Acts upstream of or within with a positive effect on DNA methylation-dependent heterochromatin formation. Acts upstream of or within several processes, including male genitalia development; meiotic nuclear division; and regulation of double-strand break repair via homologous recombination. Located in cytoplasm and nucleus. Is expressed in meninges; oocyte; sensory organ; and spinal cord mantle layer. Human ortholog(s) of this gene implicated in spermatogenic failure 25. Orthologous to human TEX15 (testis expressed 15, meiosis and synapsis associated). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in bladder adult (RPKM 4.1), testis adult (RPKM 3.8) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Tex15 in Genome Data Viewer
Location:
8 A4; 8 20.59 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (34006712..34082531)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (33516689..33592503)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21104 Neighboring gene STARR-seq mESC enhancer starr_21105 Neighboring gene translocase of outer mitochondrial membrane 40 homolog pseudogene Neighboring gene high mobility group box 1, related sequence 17 Neighboring gene STARR-seq mESC enhancer starr_21108 Neighboring gene STARR-seq mESC enhancer starr_21109 Neighboring gene protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform Neighboring gene UBX domain protein 8 Neighboring gene STARR-positive B cell enhancer ABC_E4996 Neighboring gene STARR-seq mESC enhancer starr_21112 Neighboring gene predicted gene, 33433

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TEX15 associates with MILI and silences transposable elements in male germ cells. Yang F, et al. Genes Dev, 2020 Jun 1. PMID 32381626, Free PMC Article
  2. TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing. Schöpp T, et al. Nat Commun, 2020 Jul 27. PMID 32719317, Free PMC Article
  3. The genetics of human infertility by functional interrogation of SNPs in mice. Singh P, et al. Proc Natl Acad Sci U S A, 2015 Aug 18. PMID 26240362, Free PMC Article
  4. Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis. Yang F, et al. J Cell Biol, 2008 Feb 25. PMID 18283110, Free PMC Article
  5. Identification of heat shock factor 1 molecular and cellular targets during embryonic and adult female meiosis. Le Masson F, et al. Mol Cell Biol, 2011 Aug. PMID 21690297, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TEX15 associates with MILI and silences transposable elements in male germ cells.
    Title: TEX15 associates with MILI and silences transposable elements in male germ cells.
  2. TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing.
    Title: TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing.
  3. Loss of TEX15 leads to DNA hypomethylation and de-silencing of transposable elements, at a level comparable to loss of MILI or DNMT3C but not MIWI2. TEX15 is associated with MILI in testis. piRNA biogenesis is intact in TEX15-deficient male germ cells.
    Title: TEX15 associates with MILI and silences transposable elements in male germ cells.
  4. Based on these data, we propose that TEX15 regulates the loading of DNA repair proteins onto sites of DSBs and, thus, its absence causes a failure in meiotic recombination.
    Title: Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis.
  5. Tex15 is essential for male meiosis and for chromosomal synapsis. DNA double-strand breaks (DSBs) are formed but not repaired in Tex15-deficient males.
    Title: Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within_positive_effect DNA methylation-dependent heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within male genitalia development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male meiotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in piRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization to chromosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrotransposon silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrotransposon silencing by piRNA-directed DNA methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptonemal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within synaptonemal complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
testis-expressed protein 15
Names
testis-expressed sequence 15 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031374.2 → NP_113551.2  testis-expressed protein 15

    See identical proteins and their annotated locations for NP_113551.2

    Status: VALIDATED

    Source sequence(s)
    AC139025, AF285589, BC063106
    Consensus CDS
    CCDS22232.1
    UniProtKB/Swiss-Prot
    F8VPN2, Q3UPQ6, Q3V162, Q99MV3
    Related
    ENSMUSP00000009772.8, ENSMUST00000009772.8
    Conserved Domains (1) summary
    pfam15326
    Location:1574 → 1788
    TEX15; Testis expressed sequence 15

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    34006712..34082531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508976.4 → XP_006509039.1  testis-expressed protein 15 isoform X1

    See identical proteins and their annotated locations for XP_006509039.1

    Conserved Domains (2) summary
    pfam12509
    Location:104 → 251
    DUF3715; Protein of unknown function (DUF3715)
    pfam15326
    Location:1848 → 2062
    TEX15; Testis expressed sequence 15

  2. XM_006508977.4 → XP_006509040.1  testis-expressed protein 15 isoform X1

    See identical proteins and their annotated locations for XP_006509040.1

    Conserved Domains (2) summary
    pfam12509
    Location:104 → 251
    DUF3715; Protein of unknown function (DUF3715)
    pfam15326
    Location:1848 → 2062
    TEX15; Testis expressed sequence 15

  3. XM_006508975.3 → XP_006509038.1  testis-expressed protein 15 isoform X1

    See identical proteins and their annotated locations for XP_006509038.1

    Conserved Domains (2) summary
    pfam12509
    Location:104 → 251
    DUF3715; Protein of unknown function (DUF3715)
    pfam15326
    Location:1848 → 2062
    TEX15; Testis expressed sequence 15

  4. XM_011242106.2 → XP_011240408.1  testis-expressed protein 15 isoform X1

    See identical proteins and their annotated locations for XP_011240408.1

    Conserved Domains (2) summary
    pfam12509
    Location:104 → 251
    DUF3715; Protein of unknown function (DUF3715)
    pfam15326
    Location:1848 → 2062
    TEX15; Testis expressed sequence 15

RNA

  1. XR_378774.2 RNA Sequence

  2. XR_004934745.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F8VPN2.1 GenPept UniProtKB/Swiss-Prot:F8VPN2

Gene LinkOut

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