Rexo2 RNA exonuclease 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rexo2provided by MGI
Official Full Name: RNA exonuclease 2provided by MGI
Primary source: MGI:MGI:1888981
See related: Ensembl:ENSMUSG00000032026 AllianceGenome:MGI:1888981
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sfn; Rex2; Smfn; 1810038D15Rik
Summary: Predicted to enable 3'-5'-DNA exonuclease activity; 3'-5'-RNA exonuclease activity; and magnesium ion binding activity. Predicted to be involved in DNA metabolic process. Predicted to act upstream of or within nucleobase-containing compound metabolic process. Located in mitochondrion. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Orthologous to human REXO2 (RNA exonuclease 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Ubiquitous expression in bladder adult (RPKM 86.0), liver E14 (RPKM 25.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 26.42 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (48379812..48391911, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (48468512..48480611, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Efficient RNA turnover by REXO2 is thus required to maintain promoter specificity and proper regulation of transcription in mammalian mitochondria.
Title: Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	ISO Inferred from Sequence Orthology more info	PubMed
enables 3'-5' exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables 3'-5'-DNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables 3'-5'-DNA exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables 3'-5'-RNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'-5'-RNA exonuclease activity	IEA Inferred from Electronic Annotation more info
enables 3'-5'-RNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nucleobase-containing compound metabolic process	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: oligoribonuclease, mitochondrial

Names: REX2, RNA exonuclease 2 homolog; small fragment nuclease

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357501.2 → NP_001344430.1 oligoribonuclease, mitochondrial isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC160992

UniProtKB/TrEMBL

Q3T9B4

Conserved Domains (1) summary

cd06135
Location:46 → 187

Orn; DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins
NM_001357503.1 → NP_001344432.1 oligoribonuclease, mitochondrial isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the C-terminus compared to isoform 1.

Source sequence(s)

AC160992

Consensus CDS

CCDS90558.1

UniProtKB/TrEMBL

A0A1L1SS70, Q8BJ91

Related

ENSMUSP00000149784.2, ENSMUST00000217037.2

Conserved Domains (1) summary

cl10012
Location:39 → 121

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
NM_001357505.1 → NP_001344434.1 oligoribonuclease, mitochondrial isoform 4 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC160992

Consensus CDS

CCDS90557.1

UniProtKB/TrEMBL

A0A1L1SQJ5, Q8BJ91

Related

ENSMUSP00000149074.2, ENSMUST00000216470.2

Conserved Domains (1) summary

cl10012
Location:39 → 103

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
NM_024233.4 → NP_077195.2 oligoribonuclease, mitochondrial isoform 1 precursor

See identical proteins and their annotated locations for NP_077195.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AI839882, AK007731

Consensus CDS

CCDS23154.1

UniProtKB/Swiss-Prot

Q9D8S4

UniProtKB/TrEMBL

Q3T9B4

Related

ENSMUSP00000034524.4, ENSMUST00000034524.5

Conserved Domains (1) summary

cd06135
Location:43 → 215

Orn; DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins