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PSEN2 presenilin 2 [ Microcebus murinus (gray mouse lemur) ]

Gene ID: 105863820, updated on 13-Mar-2024

Summary

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Gene symbol
PSEN2
Gene description
presenilin 2
See related
Ensembl:ENSMICG00000013427
Gene type
protein coding
RefSeq status
MODEL
Organism
Microcebus murinus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes; Cheirogaleidae; Microcebus
Also known as
PS2; PS-2; PSNL2
Orthologs
human mouse all
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Genomic context

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See PSEN2 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
14
Annotation release Status Assembly Chr Location
101 current Mmur_3.0 (GCF_000165445.2) 17 NC_033676.1 (39467695..39493458)
100 previous assembly Mmur_2.0 (GCF_000165445.1) Unplaced Scaffold NW_012202130.1 (5094875..5120638, complement)

Chromosome 17 - NC_033676.1Genomic Context describing neighboring genes Neighboring gene inositol-trisphosphate 3-kinase B Neighboring gene uncharacterized LOC105863821 Neighboring gene coenzyme Q8A Neighboring gene CDC42 binding protein kinase alpha Neighboring gene poly(ADP-ribose) glycohydrolase pseudogene Neighboring gene 60S ribosomal protein L6 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning of the presenilin 2 cDNA and its distribution in brain of the primate, Microcebus murinus: coexpression with betaAPP and Tau proteins. Calenda A, et al. Neurobiol Dis, 1998 Nov. PMID 10069575

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aspartic endopeptidase activity, intramembrane cleaving IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch receptor processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in amyloid precursor protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in amyloid-beta metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in ciliary rootlet IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendritic shaft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
presenilin-2
Names
Presenilin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Microcebus murinus Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmur_3.0 Primary Assembly

Genomic

  1. NC_033676.1 Reference Mmur_3.0 Primary Assembly

    Range
    39467695..39493458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012751324.1 → XP_012606778.1  presenilin-2 isoform X1

    UniProtKB/Swiss-Prot
    P79801
    UniProtKB/TrEMBL
    A0A8B7FEY9
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 500
    Presenilin; Presenilin

  2. XM_012751325.1 → XP_012606779.1  presenilin-2 isoform X2

    UniProtKB/Swiss-Prot
    P79801
    UniProtKB/TrEMBL
    A0A8B7FES3
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 499
    Presenilin; Presenilin

  3. XM_012751326.1 → XP_012606780.1  presenilin-2 isoform X3

    UniProtKB/Swiss-Prot
    P79801
    UniProtKB/TrEMBL
    A0A8B7FFR4
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 498
    Presenilin; Presenilin

  4. XM_020281452.1 → XP_020137041.1  presenilin-2 isoform X4

    UniProtKB/Swiss-Prot
    P79801
    UniProtKB/TrEMBL
    A0A8C5V4P5
    Related
    ENSMICP00000020216.2, ENSMICT00000038881.2
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 438
    Presenilin

  5. XM_012751327.1 → XP_012606781.1  presenilin-2 isoform X5

    UniProtKB/Swiss-Prot
    P79801
    UniProtKB/TrEMBL
    A0A8B7FES0
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 437
    Presenilin; Presenilin

  6. XM_012751331.2 → XP_012606785.1  presenilin-2 isoform X8

    UniProtKB/Swiss-Prot
    P79801
    UniProtKB/TrEMBL
    A0A8B7FFR9
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 400
    Presenilin; Presenilin

  7. XM_012751329.2 → XP_012606783.1  presenilin-2 isoform X6

    See identical proteins and their annotated locations for XP_012606783.1

    UniProtKB/Swiss-Prot
    P79801
    UniProtKB/TrEMBL
    A0A8B7FEQ5
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 400
    Presenilin; Presenilin

  8. XM_012751330.2 → XP_012606784.1  presenilin-2 isoform X7

    UniProtKB/Swiss-Prot
    P79801
    UniProtKB/TrEMBL
    A0A8B7FES9
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 400
    Presenilin; Presenilin

  9. XM_012751328.2 → XP_012606782.1  presenilin-2 isoform X6

    See identical proteins and their annotated locations for XP_012606782.1

    UniProtKB/Swiss-Prot
    P79801
    UniProtKB/TrEMBL
    A0A8B7FEQ5
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 400
    Presenilin; Presenilin

  10. XM_012751332.1 → XP_012606786.1  presenilin-2 isoform X9

    UniProtKB/TrEMBL
    A0A8B7FES5
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 396
    Presenilin; Presenilin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P79801.1 GenPept UniProtKB/Swiss-Prot:P79801

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