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Cmc4 C-X9-C motif containing 4 [ Mus musculus (house mouse) ]

Gene ID: 105886298, updated on 17-Aug-2024

Summary

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Official Symbol
Cmc4provided by MGI
Official Full Name
C-X9-C motif containing 4provided by MGI
Primary source
MGI:MGI:5637812
See related
Ensembl:ENSMUSG00000090110 AllianceGenome:MGI:5637812
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mtcp1nb; p8MTCP1
Summary
Predicted to be located in mitochondrion. Predicted to be active in mitochondrial intermembrane space. Orthologous to human CMC4 (C-X9-C motif containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 6.2), CNS E14 (RPKM 5.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X A7.3; X
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (74448452..74460190, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (75404846..75416584, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene coagulation factor VIII Neighboring gene predicted gene 8522 Neighboring gene STARR-seq mESC enhancer starr_47381 Neighboring gene STARR-seq mESC enhancer starr_47382 Neighboring gene FUN14 domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E11683 Neighboring gene mature T cell proliferation 1 Neighboring gene BRCA1/BRCA2-containing complex, subunit 3 Neighboring gene zinc finger and SCAN domain containing 12 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations. Madani A, et al. Blood, 1996 Mar 1. PMID 8634440
  2. The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein overexpressed in T cell leukemia bearing a t(X;14) translocation. Soulier J, et al. Oncogene, 1994 Dec. PMID 7970717
  3. The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial protein. Madani A, et al. Oncogene, 1995 Jun 1. PMID 7784073
  4. The murine Tcl1 oncogene: embryonic and lymphoid cell expression. Narducci MG, et al. Oncogene, 1997 Aug 18. PMID 9285687
  5. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC170438, MGC170439

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cx9C motif-containing protein 4
Names
C-x(9)-C motif containing 4
MTCP-1 type A
mature T-cell proliferation 1 neighbor protein
mature T-cell proliferation-1 type A
protein p8 MTCP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001294277.1 → NP_001281206.1  cx9C motif-containing protein 4

    See identical proteins and their annotated locations for NP_001281206.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL671860, AL731844
    Consensus CDS
    CCDS41030.1
    UniProtKB/Swiss-Prot
    Q61908
    UniProtKB/TrEMBL
    A3KGA5
    Related
    ENSMUSP00000117381.3, ENSMUST00000149863.3
    Conserved Domains (1) summary
    pfam08991
    Location:6 → 59
    MTCP1; Mature-T-Cell Proliferation I type

  2. NM_010839.6 → NP_034969.1  cx9C motif-containing protein 4

    See identical proteins and their annotated locations for NP_034969.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL671860, AL731844, DV655269
    Consensus CDS
    CCDS41030.1
    UniProtKB/Swiss-Prot
    Q61908
    UniProtKB/TrEMBL
    A3KGA5
    Related
    ENSMUSP00000033543.8, ENSMUST00000033543.14
    Conserved Domains (1) summary
    pfam08991
    Location:6 → 59
    MTCP1; Mature-T-Cell Proliferation I type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    74448452..74460190 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61908.1 GenPept UniProtKB/Swiss-Prot:Q61908

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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Research Materials