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IVNS1ABP influenza virus NS1A binding protein [ Homo sapiens (human) ]

Gene ID: 10625, updated on 10-Dec-2024

Summary

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Official Symbol
IVNS1ABPprovided by HGNC
Official Full Name
influenza virus NS1A binding proteinprovided by HGNC
Primary source
HGNC:HGNC:16951
See related
Ensembl:ENSG00000116679 MIM:609209; AllianceGenome:HGNC:16951
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ND1; ARA3; NS-1; IMD70; NS1BP; FLARA3; KLHL39; NS1-BP; HSPC068
Summary
Involved in RNA splicing; negative regulation of protein ubiquitination; and response to virus. Located in cytosol. Implicated in immunodeficiency 70. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in bone marrow (RPKM 56.1), kidney (RPKM 31.5) and 24 other tissues See more
Orthologs
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Genomic context

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See IVNS1ABP in Genome Data Viewer
Location:
1q25.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (185296388..185317243, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (184653292..184680201, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (185265520..185286375, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SWT1 RNA endoribonuclease homolog Neighboring gene ribosomal protein L5 pseudogene 5 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:185226026-185226636 Neighboring gene uncharacterized LOC105371651 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:185285701-185286314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2242 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2243 Neighboring gene microtubule associated protein 1 light chain 3 beta pseudogene Neighboring gene CBS mRNA stabilizing lncRNA Neighboring gene Sharpr-MPRA regulatory region 834 Neighboring gene RNA, U7 small nuclear 183 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. NS1-Binding protein (NS1-BP): a novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cells. Wolff T, et al. J Virol, 1998 Sep. PMID 9696811, Free PMC Article
  2. Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression. Zhang K, et al. Proc Natl Acad Sci U S A, 2018 Dec 26. PMID 30538201, Free PMC Article
  3. Crystal structure of the Kelch domain of human NS1-binding protein at 1.98 Å resolution. Guo L, et al. Acta Crystallogr F Struct Biol Commun, 2018 Mar 1. PMID 29497022, Free PMC Article
  4. Soluble NS1 Antagonizes IgG- and IgA- Mediated Monocytic Phagocytosis of DENV Infected Cells. Waldran MJ, et al. J Infect Dis, 2023 Jun 28. PMID 37103221
  5. The kelch protein NS1-BP interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. Perconti G, et al. Biochim Biophys Acta, 2007 Dec. PMID 17996313

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Soluble NS1 Antagonizes IgG- and IgA- Mediated Monocytic Phagocytosis of DENV Infected Cells.
    Title: Soluble NS1 Antagonizes IgG- and IgA- Mediated Monocytic Phagocytosis of DENV Infected Cells.
  2. The central BACK domain of NS1-BP interacts directly with splicing factors such as hnRNP K and PTBP1 and with the viral NS1 protein.
    Title: Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression.
  3. In esophageal squamous cell carcinoma (ESCC) tissues, c-Myc expression was inversely correlated with NS1-binding protein (NS1-BP) levels, and was associated with a shorter disease-specific survival (DSS).
    Title: NS1-binding protein radiosensitizes esophageal squamous cell carcinoma by transcriptionally suppressing c-Myc.
  4. Comparison of the Kelch-domain structures of NS1-BP and its homologues showed that the Gly-Gly pair in beta-strand B and the hydrophobic Trp residue in beta-strand D are highly conserved, while the B-C loops in blades 2 and 6 are variable
    Title: Crystal structure of the Kelch domain of human NS1-binding protein at 1.98 Å resolution.
  5. Data show that heterogeneous nuclear ribonucleoprotein K (hnRNP K) and influenza virus NS1A binding protein (NS1-BP) regulate host splicing events and that viral infection causes mis-splicing of some of these transcripts.
    Title: Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing.
  6. Our study identifies KLHL39 as a negative regulator of Cul3-KLHL20 ubiquitin ligase and reveals a role of KLHL39-mediated PML and DAPK stabilization in colon cancer metastasis.
    Title: KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination.
  7. NS1-BP-hnRNPK complex is a key mediator of influenza A virus gene expression.
    Title: Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing.
  8. This study provided evidence that miRNA-548an is involved in the regulation of NS1ABP.
    Title: Expression of non-structural-1A binding protein in lung epithelial cells is modulated by miRNA-548an on exposure to influenza A virus.
  9. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes.
  10. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Immunodeficiency 70
MedGen: C5436501 OMIM: 618969 GeneReviews: Not available
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag is identified to have a physical interaction with influenza virus NS1A binding protein (IVNS1ABP; NS1BP) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10069, FLJ10411, FLJ10962, FLJ35593, FLJ36593, KIAA0850, DKFZp686K06216

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription by RNA polymerase III TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex TAS
Traceable Author Statement
more info
 PubMed 
part_of transcription regulator complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
influenza virus NS1A-binding protein
Names
NCX downstream gene 1
NS1-binding protein
aryl hydrocarbon receptor-associated 3
aryl hydrocarbon receptor-associated protein 3
kelch-like family member 39
kelch-like protein 39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006469.5 → NP_006460.2  influenza virus NS1A-binding protein

    See identical proteins and their annotated locations for NP_006460.2

    Status: VALIDATED

    Source sequence(s)
    AB020657, AF205218, AK000931, AL137640
    Consensus CDS
    CCDS1368.1
    UniProtKB/Swiss-Prot
    A8K8R6, Q1G4T6, Q1G4T7, Q5TF75, Q6NW38, Q7LCG2, Q9NZX0, Q9Y480, Q9Y6Y0
    Related
    ENSP00000356468.3, ENST00000367498.8
    Conserved Domains (4) summary
    PHA03098
    Location:23 → 638
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:502 → 545
    Kelch; KELCH repeat [structural motif]
    cd18306
    Location:14 → 137
    BTB_POZ_NS1BP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP)
    cd18502
    Location:129 → 225
    BACK_NS1BP_IVNS1ABP; BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    185296388..185317243 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434096.1 → XP_047290052.1  influenza virus NS1A-binding protein isoform X2

  2. XM_047434070.1 → XP_047290026.1  influenza virus NS1A-binding protein isoform X1

    UniProtKB/Swiss-Prot
    A8K8R6, Q1G4T6, Q1G4T7, Q5TF75, Q6NW38, Q7LCG2, Q9NZX0, Q9Y480, Q9Y6Y0

  3. XM_047434109.1 → XP_047290065.1  influenza virus NS1A-binding protein isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    184653292..184680201 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333888.1 → XP_054189863.1  influenza virus NS1A-binding protein isoform X1

    UniProtKB/Swiss-Prot
    A8K8R6, Q1G4T6, Q1G4T7, Q5TF75, Q6NW38, Q7LCG2, Q9NZX0, Q9Y480, Q9Y6Y0

  2. XM_054333889.1 → XP_054189864.1  influenza virus NS1A-binding protein isoform X2

  3. XM_054333890.1 → XP_054189865.1  influenza virus NS1A-binding protein isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016389.2: Suppressed sequence

    Description
    NM_016389.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6Y0.3 GenPept UniProtKB/Swiss-Prot:Q9Y6Y0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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