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Nt5c3 5'-nucleotidase, cytosolic III [ Mus musculus (house mouse) ]

Gene ID: 107569, updated on 30-Apr-2024

Summary

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Official Symbol
Nt5c3provided by MGI
Official Full Name
5'-nucleotidase, cytosolic IIIprovided by MGI
Primary source
MGI:MGI:1927186
See related
Ensembl:ENSMUSG00000029780 AllianceGenome:MGI:1927186
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p36; Nt5y; PN-1; PN-I; PSN1; UMPH; P5N-1; Umph1; lupin; Nt5c3a; P5'N-1; Umph-1; cN-III; 1600024P05Rik; 2610206B05Rik; 3110004A18Rik
Summary
Enables 5'-nucleotidase activity. Involved in CMP catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; hemolymphoid system; liver; nervous system; and respiratory system. Orthologous to human NT5C3A (5'-nucleotidase, cytosolic IIIA). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 44.0), liver E14.5 (RPKM 35.0) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Nt5c3 in Genome Data Viewer
Location:
6 B3; 6 27.75 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (56859385..56900993, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (56882400..56924008, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene kelch repeat and BTB (POZ) domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_15991 Neighboring gene STARR-positive B cell enhancer ABC_E4829 Neighboring gene predicted gene 10209 Neighboring gene STARR-seq mESC enhancer starr_15993 Neighboring gene FK506 binding protein 9 Neighboring gene STARR-seq mESC enhancer starr_15995 Neighboring gene predicted gene, 53332 Neighboring gene STARR-positive B cell enhancer ABC_E8830 Neighboring gene STARR-seq mESC enhancer starr_15996 Neighboring gene vomeronasal 1 receptor 4 Neighboring gene vomeronasal 1 receptor 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The functional logic of cytosolic 5'-nucleotidases. Ipata PL, et al. Curr Med Chem, 2013. PMID 23992316
  2. The enzymology of cytosolic pyrimidine 5'-nucleotidases: functional analysis and physiopathological implications. Magni G, et al. Curr Med Chem, 2013. PMID 23992312
  3. Structural basis of substrate specificity and selectivity of murine cytosolic 5'-nucleotidase III. Grobosky CL, et al. J Mol Biol, 2012 Nov 2. PMID 22925580
  4. Cloning and expression analysis of murine lupin, a member of a novel gene family that is conserved through evolution and associated with Lupus inclusions. Lu MM, et al. Dev Genes Evol, 2000 Oct. PMID 11180800
  5. Isozymes of rodent 5'-nucleotidase: evidence for two independent structural loci Umph-1 and Umph-2. Swallow DM, et al. Ann Hum Genet, 1983 Jan. PMID 6301357

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5'-nucleotidase activity ISO
Inferred from Sequence Orthology
more info
  
enables 5'-nucleotidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables XMP 5'-nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CMP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in UMP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in adenosine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dCMP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dTMP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dUMP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytosolic 5'-nucleotidase 3A
Names
5'-nucleotidase, pyrimidine
7-methylguanosine nucleotidase
7-methylguanosine phosphate-specific 5'-nucleotidase
cytosolic 5'-nucleotidase 3
cytosolic 5'-nucleotidase III
pyrimidine 5'-nucleotidase 1
uridine monophosphatase 1
NP_001239303.1
NP_001347892.1
NP_080280.3
XP_006505336.1
XP_006505337.1
XP_006505338.1
XP_006505339.1
XP_011239413.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252374.1 → NP_001239303.1  cytosolic 5'-nucleotidase 3A isoform 2

    See identical proteins and their annotated locations for NP_001239303.1

    Status: VALIDATED

    Source sequence(s)
    AC153616, AK160139, BX527194, CX734167
    Consensus CDS
    CCDS57424.1
    UniProtKB/Swiss-Prot
    Q9D020
    Related
    ENSMUSP00000098918.3, ENSMUST00000101367.9
    Conserved Domains (1) summary
    cd07504
    Location:25 → 297
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

  2. NM_001360963.1 → NP_001347892.1  cytosolic 5'-nucleotidase 3A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153616, BX527194
    Consensus CDS
    CCDS57424.1
    Conserved Domains (1) summary
    cd07504
    Location:25 → 297
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

  3. NM_026004.3 → NP_080280.3  cytosolic 5'-nucleotidase 3A isoform 1

    See identical proteins and their annotated locations for NP_080280.3

    Status: VALIDATED

    Source sequence(s)
    AK011525, AK011894, BX527194, BY261587
    Consensus CDS
    CCDS20171.1
    UniProtKB/Swiss-Prot
    Q8CI05, Q9D020, Q9D0D9
    Related
    ENSMUSP00000031793.6, ENSMUST00000031793.8
    Conserved Domains (1) summary
    cd07504
    Location:59 → 331
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    56859385..56900993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241111.2 → XP_011239413.1  cytosolic 5'-nucleotidase 3A isoform X1

    See identical proteins and their annotated locations for XP_011239413.1

    UniProtKB/Swiss-Prot
    Q9D020
    Conserved Domains (1) summary
    cd07504
    Location:25 → 297
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

  2. XM_006505275.3 → XP_006505338.1  cytosolic 5'-nucleotidase 3A isoform X3

    Conserved Domains (1) summary
    cd07504
    Location:14 → 286
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

  3. XM_006505274.3 → XP_006505337.1  cytosolic 5'-nucleotidase 3A isoform X2

    Conserved Domains (1) summary
    cd07504
    Location:20 → 292
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

  4. XM_006505273.3 → XP_006505336.1  cytosolic 5'-nucleotidase 3A isoform X1

    See identical proteins and their annotated locations for XP_006505336.1

    UniProtKB/Swiss-Prot
    Q9D020
    Conserved Domains (1) summary
    cd07504
    Location:25 → 297
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

  5. XM_006505276.5 → XP_006505339.1  cytosolic 5'-nucleotidase 3A isoform X4

    Conserved Domains (1) summary
    cd07504
    Location:13 → 285
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D020.4 GenPept UniProtKB/Swiss-Prot:Q9D020

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