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Pi4kb phosphatidylinositol 4-kinase beta [ Mus musculus (house mouse) ]

Gene ID: 107650, updated on 27-Dec-2024

Summary

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Official Symbol
Pi4kbprovided by MGI
Official Full Name
phosphatidylinositol 4-kinase betaprovided by MGI
Primary source
MGI:MGI:1334433
See related
Ensembl:ENSMUSG00000038861 AllianceGenome:MGI:1334433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ESTM41; Pik4cb; PI4Kbeta; PI4K-beta
Summary
Predicted to enable 1-phosphatidylinositol 4-kinase activity and 14-3-3 protein binding activity. Predicted to be involved in inner ear development; phosphatidylinositol phosphate biosynthetic process; and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within lysosome organization. Predicted to be located in Golgi membrane. Predicted to be active in cytoplasm and membrane. Is expressed in several structures, including extraembryonic component; neural ectoderm; and vertebral axis musculature. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 87. Orthologous to human PI4KB (phosphatidylinositol 4-kinase beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 17.1), bladder adult (RPKM 16.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pi4kb in Genome Data Viewer
Location:
3 F2.1; 3 40.74 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (94882042..94914248)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (94974731..95006937)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene selenium binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E231 Neighboring gene RIKEN cDNA B230398E01 gene Neighboring gene regulatory factor X, 5 (influences HLA class II expression) Neighboring gene STARR-seq mESC enhancer starr_08361 Neighboring gene STARR-positive B cell enhancer ABC_E652 Neighboring gene STARR-positive B cell enhancer ABC_E3449 Neighboring gene zinc finger protein 687 Neighboring gene microRNA 7013 Neighboring gene RIKEN cDNA 4930481B07 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:94820548-94820749 Neighboring gene STARR-positive B cell enhancer ABC_E4560 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Locational and functional characterization of PI4KB in the mouse embryo. Zhao H, et al. J Cell Physiol, 2024 Apr. PMID 38230579
  2. Myelination of peripheral nerves is controlled by PI4KB through regulation of Schwann cell Golgi function. Baba T, et al. Proc Natl Acad Sci U S A, 2020 Nov 10. PMID 33106410, Free PMC Article
  3. Aldosterone-induced ENaC and basal Na+/K+-ATPase trafficking via protein kinase D1-phosphatidylinositol 4-kinaseIIIβ trans Golgi signalling in M1 cortical collecting duct cells. Dooley R, et al. Mol Cell Endocrinol, 2013 Jun 15. PMID 23541637
  4. PI4KIIIβ-Mediated Phosphoinositides Metabolism Regulates Function of the VTA Dopaminergic Neurons and Depression-Like Behavior. Sang Y, et al. J Neurosci, 2024 Mar 13. PMID 38267258, Free PMC Article
  5. Distinct plasma-membrane PtdIns(4)P and PtdIns(4,5)P2 dynamics in secretagogue-stimulated beta-cells. Wuttke A, et al. J Cell Sci, 2010 May 1. PMID 20375060

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Locational and functional characterization of PI4KB in the mouse embryo.
    Title: Locational and functional characterization of PI4KB in the mouse embryo.
  2. Myelination of peripheral nerves is controlled by PI4KB through regulation of Schwann cell Golgi function.
    Title: Myelination of peripheral nerves is controlled by PI4KB through regulation of Schwann cell Golgi function.
  3. oijbih iuhg iugh uh jkgh uib
    Title: Aldosterone-induced ENaC and basal Na+/K+-ATPase trafficking via protein kinase D1-phosphatidylinositol 4-kinaseIIIβ trans Golgi signalling in M1 cortical collecting duct cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol 4-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables 1-phosphatidylinositol 4-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables 14-3-3 protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in inner ear development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inner ear development ISO
Inferred from Sequence Orthology
more info
  
involved_in inner ear development ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within lysosome organization ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in rough endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylinositol 4-kinase beta
Names
phosphatidylinositol 4-kinase, catalytic, beta polypeptide
ptdIns 4-kinase beta
NP_001280644.1
NP_001280645.1
NP_780565.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293715.1 → NP_001280644.1  phosphatidylinositol 4-kinase beta isoform 1

    See identical proteins and their annotated locations for NP_001280644.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript (1) and encodes the longest isoform (1).
    Source sequence(s)
    AC087062
    Consensus CDS
    CCDS79978.1
    UniProtKB/Swiss-Prot
    Q14CH6, Q14DJ4, Q3TA58, Q68FH2, Q8BKC8, Q8C146
    UniProtKB/TrEMBL
    E9Q8A3
    Related
    ENSMUSP00000102872.3, ENSMUST00000107251.9
    Conserved Domains (1) summary
    cd05168
    Location:529 → 816
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

  2. NM_001293716.1 → NP_001280645.1  phosphatidylinositol 4-kinase beta isoform 3

    See identical proteins and their annotated locations for NP_001280645.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation from a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC087062, AK157918, BC113781, BQ443265
    Consensus CDS
    CCDS79979.1
    UniProtKB/Swiss-Prot
    Q8BKC8
    Related
    ENSMUSP00000132150.2, ENSMUST00000167008.8
    Conserved Domains (1) summary
    cd05168
    Location:197 → 484
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

  3. NM_175356.3 → NP_780565.2  phosphatidylinositol 4-kinase beta isoform 2

    See identical proteins and their annotated locations for NP_780565.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC087062, AK157918, BQ443265
    Consensus CDS
    CCDS17599.1
    UniProtKB/TrEMBL
    E9Q8A3
    Related
    ENSMUSP00000072134.6, ENSMUST00000072287.12
    Conserved Domains (1) summary
    cd05168
    Location:514 → 801
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    94882042..94914248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BKC8.2 GenPept UniProtKB/Swiss-Prot:Q8BKC8

Gene LinkOut

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