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Pacs1 phosphofurin acidic cluster sorting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 107975, updated on 8-Sep-2024

Summary

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Official Symbol
Pacs1provided by MGI
Official Full Name
phosphofurin acidic cluster sorting protein 1provided by MGI
Primary source
MGI:MGI:1277113
See related
Ensembl:ENSMUSG00000024855 AllianceGenome:MGI:1277113
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable transmembrane transporter binding activity. Acts upstream of or within protein localization to Golgi apparatus. Located in COPI-coated vesicle. Is expressed in nervous system. Human ortholog(s) of this gene implicated in Schuurs-Hoeijmakers Syndrome. Orthologous to human PACS1 (phosphofurin acidic cluster sorting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 76.2), ovary adult (RPKM 27.0) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 4.25 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5183714..5323138, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5133685..5273119, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30840 Neighboring gene heterogeneous nuclear ribonucleoprotein F pseudogene Neighboring gene STARR-seq mESC enhancer starr_45376 Neighboring gene splicing factor 3b, subunit 2 Neighboring gene STARR-seq mESC enhancer starr_45378 Neighboring gene galactose-3-O-sulfotransferase 3 Neighboring gene predicted gene, 42064

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PACS-1 and adaptor protein-1 mediate ACTH trafficking to the regulated secretory pathway. Dirk BS, et al. Biochem Biophys Res Commun, 2018 Dec 9. PMID 30458990
  2. Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases. Nair-Gill E, et al. EMBO J, 2021 May 3. PMID 33630350, Free PMC Article
  3. SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes. Burgert T, et al. Mol Cell Biol, 2013 Nov. PMID 24001769, Free PMC Article
  4. Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia. Schermer B, et al. EMBO J, 2005 Dec 21. PMID 16308564, Free PMC Article
  5. PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization. Wan L, et al. Cell, 1998 Jul 24. PMID 9695949

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases.
    Title: Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases.
  2. the roles of the phosphofurin acidic cluster sorting protein - 1 (PACS-1) and the clathrin adaptor protein 1 (AP-1) in the targeting of Pro-opiomelanocortin to dense core secretory granules.
    Title: PACS-1 and adaptor protein-1 mediate ACTH trafficking to the regulated secretory pathway.
  3. casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia
    Title: Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC37046

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in lymphocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization to Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in COPI-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphofurin acidic cluster sorting protein 1
Names
cytosolic sorting protein PACS-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362451.3 → NP_001349380.1  phosphofurin acidic cluster sorting protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125059
    UniProtKB/TrEMBL
    Q3TP27
    Conserved Domains (1) summary
    pfam10254
    Location:473 → 885
    Pacs-1; PACS-1 cytosolic sorting protein

  2. NM_001403566.1 → NP_001390495.1  phosphofurin acidic cluster sorting protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC125059
    UniProtKB/TrEMBL
    Q3TAB8

  3. NM_001403567.1 → NP_001390496.1  phosphofurin acidic cluster sorting protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC125059
    UniProtKB/TrEMBL
    Q3TAB8

  4. NM_001403568.1 → NP_001390497.1  phosphofurin acidic cluster sorting protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC125059
    UniProtKB/TrEMBL
    Q3TAB8

  5. NM_001403569.1 → NP_001390498.1  phosphofurin acidic cluster sorting protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC125059
    UniProtKB/TrEMBL
    Q3TAB8

  6. NM_001403570.1 → NP_001390499.1  phosphofurin acidic cluster sorting protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC125059
    UniProtKB/TrEMBL
    Q3TAB8

  7. NM_153129.4 → NP_694769.2  phosphofurin acidic cluster sorting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_694769.2

    Status: VALIDATED

    Source sequence(s)
    AC125059
    Consensus CDS
    CCDS29453.1
    UniProtKB/Swiss-Prot
    Q6P5H8, Q8K212
    UniProtKB/TrEMBL
    Q3TAB8
    Related
    ENSMUSP00000025786.8, ENSMUST00000025786.9
    Conserved Domains (1) summary
    pfam10254
    Location:546 → 958
    Pacs-1; PACS-1 cytosolic sorting protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5183714..5323138 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K212.2 GenPept UniProtKB/Swiss-Prot:Q8K212

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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