Babam2 BRISC and BRCA1 A complex member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Babam2provided by MGI
Official Full Name: BRISC and BRCA1 A complex member 2provided by MGI
Primary source: MGI:MGI:1333875
See related: Ensembl:ENSMUSG00000052139 AllianceGenome:MGI:1333875
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bre; 6030405P19Rik; B830038C02Rik
Summary: Enables tumor necrosis factor receptor binding activity. Predicted to be involved in several processes, including mitotic G2 DNA damage checkpoint signaling; positive regulation of DNA repair; and response to ionizing radiation. Predicted to act upstream of or within several processes, including DNA repair; apoptotic process; and chromatin organization. Predicted to be located in cytosol and nucleus. Predicted to be part of BRCA1-A complex; BRISC complex; and nuclear ubiquitin ligase complex. Is expressed in central nervous system and retina. Orthologous to human BABAM2 (BRISC and BRCA1 A complex member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 28.8), bladder adult (RPKM 19.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B1; 5 17.27 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (31855394..32242083)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (31697978..32084950)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Babam2 negatively regulates osteoclastogenesis by interacting with Hey1 to inhibit Nfatc1 transcription.
Title: Babam2 negatively regulates osteoclastogenesis by interacting with Hey1 to inhibit Nfatc1 transcription.
Bre enhances osteoblastic differentiation by promoting the Mdm2-mediated degradation of p53.
Title: Bre Enhances Osteoblastic Differentiation by Promoting the Mdm2-Mediated Degradation of p53.
results demonstrate a role for BRE in both replicative senescence and DNA damage-induced premature senescence. This can be attributed to BRE being required for BRCA1-A complex-driven HR DNA repair
Title: BRE plays an essential role in preventing replicative and DNA damage-induced premature senescence.
Depletion of BRE also increased tumor cell apoptosis, and decreased both local and metastatic tumor growth.
Title: Anti-apoptotic protein BRE/BRCC45 attenuates apoptosis through maintaining the expression of caspase inhibitor XIAP in mouse Lewis lung carcinoma D122 cells.
BRE has a role in the regulation of key proteins of the cellular stress-response machinery, including prohibitin and p53
Title: Comparative proteomic analysis reveals a function of the novel death receptor-associated protein BRE in the regulation of prohibitin and p53 expression and proliferation.
a highly conserved gene in two species can generate alternative transcripts different in both of the sequence structure and expression pattern, as well as a similar class of transcripts resulting from unconventional transcript processing.
Title: Expression of a conserved mouse stress-modulating gene, Bre: comparison with the human ortholog.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5Mit228 (e-PCR), detects polymorphism
- UniSTS:130360

D5Mit66 (e-PCR), detects polymorphism
- UniSTS:116308

D6Rat178 (e-PCR), detects polymorphism
- UniSTS:228016

RH118285 (e-PCR)
- UniSTS:123317

D5Mit148 (e-PCR), detects polymorphism
- UniSTS:130274

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables tumor necrosis factor receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2/M transition checkpoint	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA repair	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA damage checkpoint	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of DNA repair	NAS Non-traceable Author Statement more info	PubMed
involved_in response to ionizing radiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of BRCA1-A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of BRCA1-A complex	ISO Inferred from Sequence Orthology more info
part_of BRCA1-A complex	NAS Non-traceable Author Statement more info	PubMed
part_of BRISC complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of nuclear ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: BRISC and BRCA1-A complex member 2

Names: BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; brain and reproductive organ-expressed protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.