SPEM3 SPEM family member 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SPEM3provided by HGNC
Official Full Name: SPEM family member 3provided by HGNC
Primary source: HGNC:HGNC:53651
See related: Ensembl:ENSG00000283439 AllianceGenome:HGNC:53651
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to be involved in flagellated sperm motility and sperm individualization. Predicted to be located in membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis (RPKM 23.1) See more
Orthologs: mouse all
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Genomic context

Location:: 17p13.1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (7428857..7432820)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (7332911..7336874)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (7332176..7336139)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

General gene information

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Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in sperm individualization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: uncharacterized protein SPEM3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364672.1 → NP_001351601.1 uncharacterized protein SPEM3 isoform 2

Status: VALIDATED

Source sequence(s)

AC113189, HY033016

Conserved Domains (2) summary

cl26386
Location:222 → 405

DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

cl28087
Location:184 → 654

FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
NM_001364708.1 → NP_001351637.1 uncharacterized protein SPEM3 isoform 1

Status: VALIDATED

Source sequence(s)

AC113189, HY033016

Consensus CDS

CCDS92248.1

UniProtKB/Swiss-Prot

A0A1B0GUW6

Related

ENSP00000490274.1, ENST00000636696.4

Conserved Domains (2) summary

cl26386
Location:255 → 438

DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

cl28087
Location:217 → 687

FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]