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nnt2 nicotinamide nucleotide transhydrogenase 2 [ Danio rerio (zebrafish) ]

Gene ID: 108179934, updated on 19-Jun-2024

Summary

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Official Symbol
nnt2provided by ZNC
Official Full Name
nicotinamide nucleotide transhydrogenase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-091204-5
See related
Ensembl:ENSDARG00000092522 AllianceGenome:ZFIN:ZDB-GENE-091204-5
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch1073-139a18.1
Summary
Predicted to enable NAD binding activity; NAD(P)+ transhydrogenase activity; and NADP binding activity. Predicted to be involved in NADPH regeneration. Predicted to act upstream of or within proton transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human NNT (nicotinamide nucleotide transhydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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See nnt2 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (5543653..5557060)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (5690792..5704198)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene zgc:153317 Neighboring gene AFG2 AAA ATPase homolog B Neighboring gene cytochrome P450, family 1, subfamily A Neighboring gene unc-51 like kinase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Loss of Function Mutations in NNT Are Associated With Left Ventricular Noncompaction. Bainbridge MN, et al. Circ Cardiovasc Genet, 2015 Aug. PMID 26025024, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NAD(P) transhydrogenase, mitochondrial-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    5543653..5557060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017351991.2 → XP_017207480.1  NAD(P) transhydrogenase, mitochondrial-like

    UniProtKB/TrEMBL
    A0A8M6Z2N7
    Related
    ENSDARP00000114052.1, ENSDART00000136189.2
Nucleotide Protein Strain
Heading Accession and Version

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