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thbd thrombomodulin [ Danio rerio (zebrafish) ]

Gene ID: 108180329, updated on 19-Jun-2024

Summary

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Official Symbol
thbdprovided by ZNC
Official Full Name
thrombomodulinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-110411-281
See related
Ensembl:ENSDARG00000092470 AllianceGenome:ZFIN:ZDB-GENE-110411-281
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
TM-a; si:ch1073-471m19.4
Summary
Predicted to enable calcium ion binding activity and transmembrane signaling receptor activity. Predicted to be involved in elastic fiber assembly. Predicted to be located in membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in several diseases, including acute kidney failure; atypical hemolytic-uremic syndrome; cerebrovascular disease (multiple); rheumatoid arthritis; and thrombophilia (multiple). Orthologous to human THBD (thrombomodulin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See thbd in Genome Data Viewer
Location:
chromosome: 20
Exon count:
1
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (51464264..51466449)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (51651140..51653294)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene si:ch73-91k6.1 Neighboring gene uncharacterized LOC108180355 Neighboring gene toll-like receptor 5b Neighboring gene toll-like receptor 5a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A thrombomodulin-like gene is crucial to the collective migration of epibolic blastomeres during germ layer formation and organogenesis in zebrafish. Lee GH, et al. J Biomed Sci, 2019 Aug 26. PMID 31451113, Free PMC Article
  2. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within blood coagulation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hemostasis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
thrombomodulin-like
Names
thrombomodulin a

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    51464264..51466449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017352694.2 → XP_017208183.1  thrombomodulin-like

    UniProtKB/TrEMBL
    A0A8M6Z2V7
    Related
    ENSDARP00000124069.1, ENSDART00000150110.2
Nucleotide Protein Strain
Heading Accession and Version

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