U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PGRMC1 progesterone receptor membrane component 1 [ Homo sapiens (human) ]

Gene ID: 10857, updated on 10-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
PGRMC1provided by HGNC
Official Full Name
progesterone receptor membrane component 1provided by HGNC
Primary source
HGNC:HGNC:16090
See related
Ensembl:ENSG00000101856 MIM:300435; AllianceGenome:HGNC:16090
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IZA; MPR; Dap1; HPR6.6
Summary
This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in liver (RPKM 180.6), kidney (RPKM 113.3) and 24 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PGRMC1 in Genome Data Viewer
Location:
Xq24
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (119236285..119244466)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (117614039..117622220)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (118370248..118378429)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 28 Neighboring gene NUDT19 pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20953 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20954 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20955 Neighboring gene A-kinase anchoring protein 17B, pseudogene Neighboring gene Sharpr-MPRA regulatory region 13303 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20956 Neighboring gene long intergenic non-protein coding RNA 3098 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:118453061-118453562

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Changes in PGRMC1, a potential progesterone receptor, in human myometrium during pregnancy and labour at term and preterm. Wu W, et al. Mol Hum Reprod, 2011 Apr. PMID 21131300
  2. Loss of β-Arrestins or six Gα proteins in HEK293 cells caused Warburg effect and prevented progesterone-induced rapid proteasomal degradation of progesterone receptor membrane component 1. Sabbir MG, et al. J Steroid Biochem Mol Biol, 2021 Nov. PMID 34506922
  3. The relationship between follicle development and progesterone receptor membrane component-1 expression in women undergoing in vitro fertilization. Elassar A, et al. Fertil Steril, 2012 Mar. PMID 22245528, Free PMC Article
  4. Elevated progesterone receptor membrane component 1/sigma-2 receptor levels in lung tumors and plasma from lung cancer patients. Mir SU, et al. Int J Cancer, 2012 Jul 15. PMID 21918976
  5. AG-205 Upregulates Enzymes Involved in Cholesterol Biosynthesis and Steroidogenesis in Human Endometrial Cells Independently of PGRMC1 and Related MAPR Proteins. Thieffry C, et al. Biomolecules, 2021 Oct 6. PMID 34680104, Free PMC Article

See all (243) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PGRMC1 promotes NSCLC stemness phenotypes by disrupting TRIM56-mediated ubiquitination of AHR.
    Title: PGRMC1 promotes NSCLC stemness phenotypes by disrupting TRIM56-mediated ubiquitination of AHR.
  2. Progesterone-mediated remodeling of the maternal-fetal interface by a PGRMC1-dependent mechanism.
    Title: Progesterone-mediated remodeling of the maternal-fetal interface by a PGRMC1-dependent mechanism.
  3. Defining Requirements for Heme Binding in PGRMC1 and Identifying Key Elements that Influence Protein Dimerization.
    Title: Defining Requirements for Heme Binding in PGRMC1 and Identifying Key Elements that Influence Protein Dimerization.
  4. Progesterone-induced progesterone receptor membrane component 1 rise-to-decline changes are essential for decidualization.
    Title: Progesterone-induced progesterone receptor membrane component 1 rise-to-decline changes are essential for decidualization.
  5. Progesterone receptor membrane component 1 facilitates Ca[2+] signal amplification between endosomes and the endoplasmic reticulum.
    Title: Progesterone receptor membrane component 1 facilitates Ca(2+) signal amplification between endosomes and the endoplasmic reticulum.
  6. Downregulation of PGRMC1 accelerates differentiation and fusion of a human trophoblast cell line.
    Title: Downregulation of PGRMC1 accelerates differentiation and fusion of a human trophoblast cell line.
  7. Regulatory action of PGRMC1 on cyclic AMP-mediated COX2 expression in human endometrial cells.
    Title: Regulatory action of PGRMC1 on cyclic AMP-mediated COX2 expression in human endometrial cells.
  8. Progesterone Receptor Membrane Component 1 (PGRMC1) Modulates Tumour Progression, the Immune Microenvironment and the Response to Therapy in Glioblastoma.
    Title: Progesterone Receptor Membrane Component 1 (PGRMC1) Modulates Tumour Progression, the Immune Microenvironment and the Response to Therapy in Glioblastoma.
  9. Expression of PGRMC1 in patients with polycystic ovary syndrome and its molecular mechanism for regulating ovarian granulosa cell apoptosis and glucolipid metabolism.
    Title: Expression of PGRMC1 in patients with polycystic ovary syndrome and its molecular mechanism for regulating ovarian granulosa cell apoptosis and glucolipid metabolism.
  10. PGRMC1 promotes triple-negative breast cancer cell growth via suppressing ferroptosis.
    Title: PGRMC1 promotes triple-negative breast cancer cell growth via suppressing ferroptosis.
Submit: New GeneRIF Correction See all GeneRIFs (99)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with progesterone receptor membrane component 1 (PGRMC1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with progesterone receptor membrane component 1 (PGRMC1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables amyloid-beta binding TAS
Traceable Author Statement
more info
 PubMed 
enables heme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme binding TAS
Traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heme biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of lipoprotein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell body ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in smooth endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in specific granule membrane TAS
Traceable Author Statement
more info
  
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
membrane-associated progesterone receptor component 1
Names
progesterone binding protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016756.1 RefSeqGene

    Range
    5038..13219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001282621.2 → NP_001269550.1  membrane-associated progesterone receptor component 1 isoform 2

    See identical proteins and their annotated locations for NP_001269550.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AC004835, AK293618, HY166171, R49086
    Consensus CDS
    CCDS65313.1
    UniProtKB/Swiss-Prot
    O00264
    Related
    ENSP00000442821.1, ENST00000535419.2
    Conserved Domains (1) summary
    cl02041
    Location:74 → 107
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

  2. NM_006667.5 → NP_006658.1  membrane-associated progesterone receptor component 1 isoform 1

    See identical proteins and their annotated locations for NP_006658.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC004835, Y12711
    Consensus CDS
    CCDS14576.1
    UniProtKB/Swiss-Prot
    B7Z1L3, O00264, Q9UGJ9
    UniProtKB/TrEMBL
    Q6IB11
    Related
    ENSP00000217971.7, ENST00000217971.8
    Conserved Domains (1) summary
    pfam00173
    Location:74 → 137
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    119236285..119244466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    117614039..117622220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O00264.3 GenPept UniProtKB/Swiss-Prot:O00264

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous