Cops8 COP9 signalosome subunit 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cops8provided by MGI
Official Full Name: COP9 signalosome subunit 8provided by MGI
Primary source: MGI:MGI:1915363
See related: Ensembl:ENSMUSG00000034432 AllianceGenome:MGI:1915363
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Csn8; Sgn8; 9430009J09Rik
Summary: Predicted to be involved in activation of NF-kappaB-inducing kinase activity; cellular protein modification process; and negative regulation of cell population proliferation. Located in nucleus. Part of COP9 signalosome. Is expressed in several structures, including early embryo; liver; and oocyte. Orthologous to human COPS8 (COP9 signalosome subunit 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 39.3), CNS E11.5 (RPKM 39.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 D; 1 45.53 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (90531147..90541063)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (90602960..90613341)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CSN8/CSN promotes the ubiquitination and degradation of misfolded proteins and protects against cardiac proteotoxicity, and cullin-RING ligases participate in degradation of cytosolic misfolded proteins.
Title: COP9 signalosome controls the degradation of cytosolic misfolded proteins and protects against cardiac proteotoxicity.
Csn8 exerts profound impacts on hepatic ubiquitin-proteasome system function and is critical to the stability of the pro-apoptotic protein Bim.
Title: Hepatic deficiency of COP9 signalosome subunit 8 induces ubiquitin-proteasome system impairment and Bim-mediated apoptosis in murine livers.
CSN8/COP9 signalosome regulates both proteasome-mediated proteolysis and the autophagic-lysosomal pathway, critical to the removal of oxidized proteins in the heart.
Title: The COP9 signalosome is required for autophagy, proteasome-mediated proteolysis, and cardiomyocyte survival in adult mice.
Data indicate that a decreased level of Csn8 accelerated cell growth and shortened G1 duration.
Title: COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase.
Likely through regulating the expression of Rab7, Csn8/CSN plays a critical role in autophagosome maturation in myocardium.
Title: COP9 signalosome regulates autophagosome maturation.
The Csn8 is essential to the ability of mature hepatocytes to proliferate effectively in response to hepatic injury.
Title: COP9 signalosome subunit 8 is required for postnatal hepatocyte survival and effective proliferation.
Csn8/CSN plays an essential role in cullin deneddylation, UPS-mediated degradation of a subset of proteins, and the survival of cardiomyocytes
Title: Perturbation of cullin deneddylation via conditional Csn8 ablation impairs the ubiquitin-proteasome system and causes cardiomyocyte necrosis and dilated cardiomyopathy in mice.
involved in the transcriptional regulation of cell-specific gene expression
Title: The COP9 signalosome negatively regulates proteasome proteolytic function and is essential to transcription.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125786 (e-PCR)
- UniSTS:162533

RH124689 (e-PCR)
- UniSTS:161511

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in COP9 signalosome assembly	IEA Inferred from Electronic Annotation more info
involved_in activation of NF-kappaB-inducing kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in protein deneddylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	IBA Inferred from Biological aspect of Ancestor more info
part_of COP9 signalosome	IDA Inferred from Direct Assay more info	PubMed
part_of COP9 signalosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: COP9 signalosome complex subunit 8

Names: COP9 (constitutive photomorphogenic) homolog, subunit 8; COP9 homolog; JAB1-containing signalosome subunit 8; signalosome subunit 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133805.3 → NP_598566.3 COP9 signalosome complex subunit 8

See identical proteins and their annotated locations for NP_598566.3

Status: VALIDATED

Source sequence(s)

AC110895, AK079111, DV645014

Consensus CDS

CCDS15153.1

UniProtKB/Swiss-Prot

Q3TRS9, Q80XF4, Q8R4D2, Q8VBV7

Related

ENSMUSP00000035884.6, ENSMUST00000036153.12

Conserved Domains (1) summary

pfam10075
Location:31 → 166

CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

90531147..90541063

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529064.4 → XP_006529127.1 COP9 signalosome complex subunit 8 isoform X1

Conserved Domains (1) summary

pfam10075
Location:3 → 133

CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family