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Rbm15b RNA binding motif protein 15B [ Mus musculus (house mouse) ]

Gene ID: 109095, updated on 2-Nov-2024

Summary

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Official Symbol
Rbm15bprovided by MGI
Official Full Name
RNA binding motif protein 15Bprovided by MGI
Primary source
MGI:MGI:1923598
See related
Ensembl:ENSMUSG00000074102 AllianceGenome:MGI:1923598
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810017N16Rik
Summary
Predicted to enable mRNA binding activity. Involved in mRNA export from nucleus. Located in nuclear envelope and nuclear speck. Is expressed in central nervous system and sensory organ. Orthologous to human RBM15B (RNA binding motif protein 15B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human all
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Genomic context

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See Rbm15b in Genome Data Viewer
Location:
9 F1; 9 57.98 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106758127..106764274, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106880928..106887075, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene testis expressed gene 264 ER-phagy receptor Neighboring gene STARR-seq mESC enhancer starr_25160 Neighboring gene RAD54 like 2 (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_25163 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:106723938-106724121 Neighboring gene STARR-positive B cell enhancer ABC_E8313 Neighboring gene DDB1 and CUL4 associated factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E9334 Neighboring gene STARR-positive B cell enhancer ABC_E460 Neighboring gene dedicator of cyto-kinesis 3 Neighboring gene mesencephalic astrocyte-derived neurotrophic factor Neighboring gene predicted gene, 18542

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1. Uranishi H, et al. J Biol Chem, 2009 Sep 18. PMID 19586903, Free PMC Article
  2. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  3. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1.
    Title: The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA methylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in dosage compensation by inactivation of X chromosome ISO
Inferred from Sequence Orthology
more info
  
involved_in dosage compensation by inactivation of X chromosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA export from nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of RNA N6-methyladenosine methyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of RNA N6-methyladenosine methyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative RNA-binding protein 15B
Names
RNA binding motif protein 15 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175402.5 → NP_780611.3  putative RNA-binding protein 15B

    See identical proteins and their annotated locations for NP_780611.3

    Status: VALIDATED

    Source sequence(s)
    AC147636
    Consensus CDS
    CCDS52915.1
    UniProtKB/Swiss-Prot
    Q6PHZ5, Q8C6G2
    Related
    ENSMUSP00000059330.8, ENSMUST00000055843.9
    Conserved Domains (5) summary
    cd12554
    Location:134 → 215
    RRM1_RBM15B; RNA recognition motif 1 in putative RNA binding motif protein 15B (RBM15B) from vertebrate
    cd12556
    Location:325 → 409
    RRM2_RBM15B; RNA recognition motif 2 in putative RNA binding motif protein 15B (RBM15B) from vertebrate
    cd12558
    Location:412 → 487
    RRM3_RBM15B; RNA recognition motif 3 in putative RNA-binding protein 15B (RBM15B) from vertebrate
    pfam07744
    Location:719 → 854
    SPOC; SPOC domain
    pfam10500
    Location:568 → 712
    SR-25; Nuclear RNA-splicing-associated protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    106758127..106764274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_020925.1: Suppressed sequence

    Description
    NG_020925.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PHZ5.2 GenPept UniProtKB/Swiss-Prot:Q6PHZ5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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