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Rlf rearranged L-myc fusion sequence [ Mus musculus (house mouse) ]

Gene ID: 109263, updated on 9-Dec-2024

Summary

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Official Symbol
Rlfprovided by MGI
Official Full Name
rearranged L-myc fusion sequenceprovided by MGI
Primary source
MGI:MGI:1924705
See related
Ensembl:ENSMUSG00000049878 AllianceGenome:MGI:1924705
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MommeD8; 9230110M18Rik
Summary
Enables DNA binding activity. Acts upstream of or within negative regulation of heterochromatin formation and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; liver; male reproductive system; spleen; and urinary system. Orthologous to human RLF (RLF zinc finger). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.5), CNS E18 (RPKM 5.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Rlf in Genome Data Viewer
Location:
4 D2.2; 4 56.8 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (121003080..121072318, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (121145883..121215121, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene SEC61 translocon subunit gamma, pseudogene 3 Neighboring gene predicted gene 12882 Neighboring gene STARR-positive B cell enhancer ABC_E8954 Neighboring gene STARR-seq mESC enhancer starr_11261 Neighboring gene predicted gene, 30102 Neighboring gene predicted gene, 40239 Neighboring gene STARR-seq mESC enhancer starr_11263 Neighboring gene STARR-seq mESC enhancer starr_11264 Neighboring gene predicted gene 12888

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development. Ashe A, et al. Genome Biol, 2008. PMID 19099580, Free PMC Article
  2. The recently identified modifier of murine metastable epialleles, Rearranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers. Harten SK, et al. BMC Biol, 2015 Mar 26. PMID 25857663, Free PMC Article
  3. An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse. Daxinger L, et al. Genome Biol, 2013. PMID 24025402, Free PMC Article
  4. Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation. Del Monte-Nieto G, et al. Nature, 2018 May. PMID 29743679
  5. Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse. Bourke LM, et al. Differentiation, 2017 Mar-Apr. PMID 27930960

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our study highlights the importance of RLF-dependent epigenetic modifications to DNA for maintaining correct gene regulatory network and intercellular signalling interactions during heart chamber and septal development.
    Title: Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.
  2. This study provides the first evidence that the epigenetic modifier Rlf is involved in the maintenance of DNA methylation at enhancers and CpG island shores across the genome.
    Title: The recently identified modifier of murine metastable epialleles, Rearranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (3)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein Rlf

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346660.1 → NP_001333589.1  zinc finger protein Rlf

    Status: VALIDATED

    Source sequence(s)
    AL606927
    Consensus CDS
    CCDS84789.1
    UniProtKB/TrEMBL
    A2A7F4, E9Q532
    Related
    ENSMUSP00000050825.6, ENSMUST00000056635.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    121003080..121072318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319915.2 → XP_017175404.1  zinc finger protein Rlf isoform X1

    UniProtKB/TrEMBL
    E9Q532
    Conserved Domains (2) summary
    COG5236
    Location:426 → 602
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:496 → 516
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_006502657.4 → XP_006502720.1  zinc finger protein Rlf isoform X1

    See identical proteins and their annotated locations for XP_006502720.1

    UniProtKB/TrEMBL
    E9Q532
    Conserved Domains (2) summary
    COG5236
    Location:426 → 602
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:496 → 516
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_006502658.2 → XP_006502721.1  zinc finger protein Rlf isoform X1

    See identical proteins and their annotated locations for XP_006502721.1

    UniProtKB/TrEMBL
    E9Q532
    Conserved Domains (2) summary
    COG5236
    Location:426 → 602
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:496 → 516
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_036163579.1 → XP_036019472.1  zinc finger protein Rlf isoform X1

    UniProtKB/TrEMBL
    E9Q532
    Conserved Domains (2) summary
    COG5236
    Location:426 → 602
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:496 → 516
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_030253080.2 → XP_030108940.1  zinc finger protein Rlf isoform X1

    UniProtKB/TrEMBL
    E9Q532
    Conserved Domains (2) summary
    COG5236
    Location:426 → 602
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:496 → 516
    ZF_C2H2; C2H2 Zn finger [structural motif]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081013.1: Suppressed sequence

    Description
    NM_001081013.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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