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Slc5a10 solute carrier family 5 (sodium/glucose cotransporter), member 10 [ Mus musculus (house mouse) ]

Gene ID: 109342, updated on 9-Dec-2024

Summary

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Official Symbol
Slc5a10provided by MGI
Official Full Name
solute carrier family 5 (sodium/glucose cotransporter), member 10provided by MGI
Primary source
MGI:MGI:1926089
See related
Ensembl:ENSMUSG00000042371 AllianceGenome:MGI:1926089
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SGLT5; C330021F16Rik
Summary
Enables fructose:sodium symporter activity and mannose:sodium symporter activity. Predicted to be involved in fructose transmembrane transport; mannose transmembrane transport; and sodium ion transport. Predicted to be located in apical plasma membrane. Predicted to be active in plasma membrane. Orthologous to human SLC5A10 (solute carrier family 5 member 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in kidney adult (RPKM 128.6) and large intestine adult (RPKM 4.5) See more
Orthologs
human all
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Genomic context

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See Slc5a10 in Genome Data Viewer
Location:
11 B2; 11 37.96 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61563608..61611641, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61672782..61720817, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene B9 protein domain 1, opposite strand Neighboring gene B9 protein domain 1 Neighboring gene epsin 2 Neighboring gene STARR-seq mESC enhancer starr_29682 Neighboring gene STARR-positive B cell enhancer ABC_E3957 Neighboring gene STARR-positive B cell enhancer ABC_E3958 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:61483303-61483412 Neighboring gene GRB2-related adaptor protein Neighboring gene family with sequence similarity 83, member G Neighboring gene phosphoribosyl pyrophosphate synthetase-associated protein 2 Neighboring gene STARR-seq mESC enhancer starr_29688 Neighboring gene unc-51 like kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose. Fukuzawa T, et al. PLoS One, 2013. PMID 23451068, Free PMC Article
  2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show fructose-induced hepatic steatosis was exacerbated in the SGLT5-deficient mice
    Title: SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-glucose:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructose:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fructose:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables mannose:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mannose:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in fructose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mannose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sodium/mannose cotransporter SLC5A10
Names
Na(+)/glucose cotransporter 5
sodium/glucose cotransporter 5
solute carrier family 5 member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033227.2 → NP_001028399.1  sodium/mannose cotransporter SLC5A10

    See identical proteins and their annotated locations for NP_001028399.1

    Status: VALIDATED

    Source sequence(s)
    AK144033
    Consensus CDS
    CCDS24818.1
    UniProtKB/Swiss-Prot
    B9EJ50, Q5SWY8
    UniProtKB/TrEMBL
    F6UXY4
    Related
    ENSMUSP00000054407.5, ENSMUST00000051552.11
    Conserved Domains (1) summary
    cl00456
    Location:17 → 596
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. NM_001382268.1 → NP_001369197.1  sodium/mannose cotransporter SLC5A10

    Status: VALIDATED

    Source sequence(s)
    AL596209
    UniProtKB/Swiss-Prot
    B9EJ50, Q5SWY8
    UniProtKB/TrEMBL
    F6UXY4
    Related
    ENSMUSP00000114523.2, ENSMUST00000148584.2
    Conserved Domains (1) summary
    cl00456
    Location:17 → 596
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    61563608..61611641 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531980.5 → XP_006532043.1  sodium/mannose cotransporter SLC5A10 isoform X3

    See identical proteins and their annotated locations for XP_006532043.1

    UniProtKB/Swiss-Prot
    B9EJ50, Q5SWY8
    UniProtKB/TrEMBL
    F6UXY4
    Conserved Domains (1) summary
    cl00456
    Location:17 → 596
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. XM_006531979.5 → XP_006532042.1  sodium/mannose cotransporter SLC5A10 isoform X2

    UniProtKB/TrEMBL
    F6UXY4
    Related
    ENSMUSP00000118196.2, ENSMUST00000151780.8
    Conserved Domains (1) summary
    cl00456
    Location:52 → 604
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. XM_006531978.5 → XP_006532041.1  sodium/mannose cotransporter SLC5A10 isoform X1

    UniProtKB/TrEMBL
    F6UXY4
    Conserved Domains (1) summary
    cl00456
    Location:52 → 611
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  4. XM_006531981.5 → XP_006532044.1  sodium/mannose cotransporter SLC5A10 isoform X4

    Conserved Domains (1) summary
    cl00456
    Location:52 → 363
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SWY8.1 GenPept UniProtKB/Swiss-Prot:Q5SWY8

Gene LinkOut

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