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Pgc progastricsin (pepsinogen C) [ Mus musculus (house mouse) ]

Gene ID: 109820, updated on 4-Jan-2025

Summary

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Official Symbol
Pgcprovided by MGI
Official Full Name
progastricsin (pepsinogen C)provided by MGI
Primary source
MGI:MGI:98909
See related
Ensembl:ENSMUSG00000023987 AllianceGenome:MGI:98909
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Upg1; Upg-1; 2210410L06Rik
Summary
Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in positive regulation of antibacterial peptide production and proteolysis. Predicted to be active in extracellular space. Is expressed in gut and lung. Orthologous to human PGC (progastricsin). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward duodenum adult (RPKM 123.5) See more
Orthologs
human all
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Genomic context

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See Pgc in Genome Data Viewer
Location:
17 C; 17 23.98 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48037767..48045403)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47726842..47734478)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42721 Neighboring gene fibroblast growth factor receptor substrate 3 Neighboring gene fibroblast growth factor receptor substrate 3, opposite strand Neighboring gene STARR-seq mESC enhancer starr_42724 Neighboring gene predicted gene, 46579 Neighboring gene STARR-positive B cell enhancer ABC_E10960 Neighboring gene STARR-positive B cell enhancer ABC_E5617 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47876786-47876895 Neighboring gene transcription factor EB Neighboring gene STARR-positive B cell enhancer ABC_E2491 Neighboring gene STARR-positive B cell enhancer ABC_E5618 Neighboring gene STARR-seq mESC enhancer starr_42729 Neighboring gene MyoD family inhibitor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The relationship between pepsinogen C and gastric carcinogenesis: a transgene and population study.
    Title: The relationship between pepsinogen C and gastric carcinogenesis: a transgene and population study.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC117575

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables aspartic-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in digestion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of antibacterial peptide production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of antibacterial peptide production ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
gastricsin
Names
pepsinogen C
urinary pepsinogen 1
NP_080249.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025973.3 → NP_080249.2  gastricsin precursor

    See identical proteins and their annotated locations for NP_080249.2

    Status: PROVISIONAL

    Source sequence(s)
    AK008959
    Consensus CDS
    CCDS28855.1
    UniProtKB/Swiss-Prot
    Q9D7R7, Q9D7T2
    Related
    ENSMUSP00000024782.6, ENSMUST00000024782.12
    Conserved Domains (3) summary
    pfam00026
    Location:75 → 390
    Asp; Eukaryotic aspartyl protease
    pfam07966
    Location:18 → 46
    A1_Propeptide; A1 Propeptide
    cl11403
    Location:73 → 391
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    48037767..48045403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D7R7.1 GenPept UniProtKB/Swiss-Prot:Q9D7R7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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