Gpr18 G protein-coupled receptor 18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr18provided by MGI
Official Full Name: G protein-coupled receptor 18provided by MGI
Primary source: MGI:MGI:107859
See related: Ensembl:ENSMUSG00000050350 AllianceGenome:MGI:107859
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable G protein-coupled receptor activity. Acts upstream of or within T cell differentiation; negative regulation of leukocyte chemotaxis; and negative regulation of tumor necrosis factor production. Predicted to be located in cytoplasmic vesicle and plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Orthologous to human GPR18 (G protein-coupled receptor 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 55.1), mammary gland adult (RPKM 20.1) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 E5; 14 65.86 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (122148846..122153300, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (121911434..121915888, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The resolvin D2 - GPR18 axis is expressed in human coronary atherosclerosis and transduces atheroprotection in apolipoprotein E deficient mice.
Title: The resolvin D2 - GPR18 axis is expressed in human coronary atherosclerosis and transduces atheroprotection in apolipoprotein E deficient mice.
this study shows that Gpr18 contributes to establishment of the CD8 effector T cell compartment
Title: G-Protein Coupled Receptor 18 Contributes to Establishment of the CD8 Effector T Cell Compartment.
GPR18 and its ligand NAGly are modulators of glial and neuronal cells during neuronal damage.
Title: Protective Effect of N-Arachidonoyl Glycine-GPR18 Signaling after Excitotoxical Lesion in Murine Organotypic Hippocampal Slice Cultures.
Our results support FAAH-dependent NAGly action at GPR18 as the physiologic basis of the diurnal variation of intraocular pressure in mice.
Title: Evidence for a GPR18 Role in Diurnal Regulation of Intraocular Pressure.
GPR18 has a role in the development and reconstitution of thymus-derived intestinal IEL subsets in the steady-state and after bone marrow transplantation
Title: GPR18 Controls Reconstitution of Mouse Small Intestine Intraepithelial Lymphocytes following Bone Marrow Transplantation.
Data indicate that orphan G-protein-coupled receptor GPR18 is required for the normal homeostasis of CD8alphaalpha gammadeltaT and alphabetaT and CD8alphabeta intestinal intraepithelial lymphocyte compartment.
Title: GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment.
Data (including data from knockout mice) suggest that signal transduction involving GPR18 in corneal epithelium and ciliary epithelium is required for regulation of intraocular pressure.
Title: A GPR18-based signalling system regulates IOP in murine eye.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within CD8-positive, alpha-beta intraepithelial T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within CD8-positive, alpha-beta intraepithelial T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within CD8-positive, gamma-delta intraepithelial T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within CD8-positive, gamma-delta intraepithelial T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of leukocyte chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: N-arachidonyl glycine receptor

Names: NAGly receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.