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Hbb-hs-85.5 beta-globin -85 hypersensitive sites [ Mus musculus (house mouse) ]

Gene ID: 110740347, updated on 8-Feb-2024

Summary

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Gene symbol
Hbb-hs-85.5
Gene description
beta-globin -85 hypersensitive sites
Gene type
biological region
Feature type(s)
protein_bind
regulatory: DNase_I_hypersensitive_site
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
-85HSs; HS-84.5; HS-85.5; Rr366809; 5'HS-84/-85
Summary
This region represents two DNase I hypersensitive sites (HSs), HS-84.5 and HS-85.5, which are located approximately 85 kb upstream of the Hbb-y (hemoglobin Y, beta-like embryonic chain) gene in the beta-globin gene cluster. The -85.5 HS can bind the CTCF transcription factor. These HSs are not conserved in human. [provided by RefSeq, Jul 2017]
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Genomic context

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See Hbb-hs-85.5 in Genome Data Viewer
Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (103590756..103592555)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (103941549..103943348)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 51 subfamily M member 1 Neighboring gene olfactory receptor family 51 subfamily AI member 2 Neighboring gene olfactory receptor family 51 subfamily K member 2 Neighboring gene olfactory receptor family 51 subfamily K member 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cohesin mediates chromatin interactions that regulate mammalian β-globin expression. Chien R, et al. J Biol Chem, 2011 May 20. PMID 21454523, Free PMC Article
  2. Three-dimensional organization of gene expression in erythroid cells. de Laat W, et al. Curr Top Dev Biol, 2008. PMID 18282519
  3. CTCF: the protein, the binding partners, the binding sites and their chromatin loops. Holwerda SJ, et al. Philos Trans R Soc Lond B Biol Sci, 2013. PMID 23650640, Free PMC Article
  4. Joining the loops: beta-globin gene regulation. Noordermeer D, et al. IUBMB Life, 2008 Dec. PMID 18767169
  5. Beta-globin regulation and long-range interactions. Palstra RJ, et al. Adv Genet, 2008. PMID 18282504

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Other Names

  • regulatory region 366809

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055465.1 

    Range
    101..1900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    103590756..103592555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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