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GLMP glycosylated lysosomal membrane protein [ Homo sapiens (human) ]

Gene ID: 112770, updated on 3-Nov-2024

Summary

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Official Symbol
GLMPprovided by HGNC
Official Full Name
glycosylated lysosomal membrane proteinprovided by HGNC
Primary source
HGNC:HGNC:29436
See related
Ensembl:ENSG00000198715 MIM:619958; AllianceGenome:HGNC:29436
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCU-G1; C1orf85; lnc-UCID
Summary
Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol; lysosome; and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in prostate (RPKM 30.2), placenta (RPKM 24.2) and 25 other tissues See more
Orthologs
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Genomic context

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See GLMP in Genome Data Viewer
Location:
1q22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156292688..156295679, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155431151..155434142, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156262479..156265470, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PMF1-BGLAP readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1424 Neighboring gene Sharpr-MPRA regulatory region 3040 Neighboring gene progestin and adipoQ receptor family member 6 Neighboring gene SMG5 nonsense mediated mRNA decay factor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156250697-156251670 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1425 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:156252643-156253614 Neighboring gene Sharpr-MPRA regulatory regions 9834 and 13552 Neighboring gene transmembrane protein 79 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156271210-156271710 Neighboring gene MPRA-validated peak424 silencer Neighboring gene VHL like Neighboring gene chaperonin containing TCP1 subunit 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156297025-156297871 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:156297872-156298717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1858 Neighboring gene TSSK6 activating cochaperone

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. N4-acetylcytidine-dependent GLMP mRNA stabilization by NAT10 promotes head and neck squamous cell carcinoma metastasis and remodels tumor microenvironment through MAPK/ERK signaling pathway. Liu Y, et al. Cell Death Dis, 2023 Nov 1. PMID 37914704, Free PMC Article
  2. Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator. Steffensen KR, et al. BMC Mol Biol, 2007 Nov 16. PMID 18021396, Free PMC Article
  3. NCU-G1 is a highly glycosylated integral membrane protein of the lysosome. Schieweck O, et al. Biochem J, 2009 Jul 29. PMID 19489740
  4. The lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP. Massa López D, et al. Elife, 2019 Oct 29. PMID 31661432, Free PMC Article
  5. A gene network regulating lysosomal biogenesis and function. Sardiello M, et al. Science, 2009 Jul 24. PMID 19556463

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N4-acetylcytidine-dependent GLMP mRNA stabilization by NAT10 promotes head and neck squamous cell carcinoma metastasis and remodels tumor microenvironment through MAPK/ERK signaling pathway.
    Title: N4-acetylcytidine-dependent GLMP mRNA stabilization by NAT10 promotes head and neck squamous cell carcinoma metastasis and remodels tumor microenvironment through MAPK/ERK signaling pathway.
  2. NCU-G1 is a dual-function protein capable of functioning as a transcription factor as well as a nuclear receptor co-activator.
    Title: Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC31963

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glycosylated lysosomal membrane protein
Names
kidney lysosomal membrane protein
kidney predominant protein NCU-G1
lncRNA up-regulating CDK6 by interacting with DHX9
lysosomal protein NCU-G1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256604.2 → NP_001243533.1  glycosylated lysosomal membrane protein isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BP302818, CA428514, CX756681, DA537642
    Conserved Domains (1) summary
    pfam15065
    Location:55 → 328
    NCU-G1; Lysosomal transcription factor, NCU-G1

  2. NM_001256605.2 → NP_001243534.1  glycosylated lysosomal membrane protein isoform 3 precursor

    See identical proteins and their annotated locations for NP_001243534.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL528533, BM833126, CA428514, DA537642
    Consensus CDS
    CCDS72948.1
    UniProtKB/TrEMBL
    A0A087WV34
    Related
    ENSP00000479149.1, ENST00000622703.4
    Conserved Domains (1) summary
    pfam15065
    Location:40 → 291
    NCU-G1; Lysosomal transcription factor, NCU-G1

  3. NM_001256608.2 → NP_001243537.1  glycosylated lysosomal membrane protein isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AW293248, CN479212, CX756681, DA537642, N72839
    Consensus CDS
    CCDS72949.1
    UniProtKB/TrEMBL
    A0A087X0W3
    Related
    ENSP00000483691.1, ENST00000612353.4
    Conserved Domains (1) summary
    pfam15065
    Location:55 → 267
    NCU-G1; Lysosomal transcription factor, NCU-G1

  4. NM_001256609.2 → NP_001243538.1  glycosylated lysosomal membrane protein isoform 5

    See identical proteins and their annotated locations for NP_001243538.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (5) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK296157, CA428514, DA537642
    Consensus CDS
    CCDS72947.1
    UniProtKB/Swiss-Prot
    Q8WWB7
    Related
    ENSP00000480936.1, ENST00000614643.4
    Conserved Domains (1) summary
    pfam15065
    Location:1 → 296
    NCU-G1; Lysosomal transcription factor, NCU-G1

  5. NM_144580.3 → NP_653181.1  glycosylated lysosomal membrane protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_653181.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC018757, DA537642, N72839
    Consensus CDS
    CCDS1139.1
    UniProtKB/Swiss-Prot
    A6NH16, B4DJN4, Q5SZX4, Q6UX96, Q8IV07, Q8WWB7, Q96F65
    Related
    ENSP00000354553.1, ENST00000362007.6
    Conserved Domains (1) summary
    pfam15065
    Location:55 → 377
    NCU-G1; Lysosomal transcription factor, NCU-G1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    156292688..156295679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442998.1 → XP_047298954.1  glycosylated lysosomal membrane protein isoform X1

  2. XM_011509117.4 → XP_011507419.1  glycosylated lysosomal membrane protein isoform X2

    Conserved Domains (1) summary
    pfam15065
    Location:2 → 200
    NCU-G1; Lysosomal transcription factor, NCU-G1

RNA

  1. XR_426762.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    155431151..155434142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334008.1 → XP_054189983.1  glycosylated lysosomal membrane protein isoform X1

  2. XM_054334009.1 → XP_054189984.1  glycosylated lysosomal membrane protein isoform X2

RNA

  1. XR_008485882.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WWB7.1 GenPept UniProtKB/Swiss-Prot:Q8WWB7

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