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WDR89 WD repeat domain 89 [ Homo sapiens (human) ]

Gene ID: 112840, updated on 27-Nov-2024

Summary

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Official Symbol
WDR89provided by HGNC
Official Full Name
WD repeat domain 89provided by HGNC
Primary source
HGNC:HGNC:20489
See related
Ensembl:ENSG00000140006 AllianceGenome:HGNC:20489
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSTP050; C14orf150
Summary
Predicted to act upstream of or within corpus callosum development and ventricular system development. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lymph node (RPKM 4.5), thyroid (RPKM 4.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See WDR89 in Genome Data Viewer
Location:
14q23.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (63597039..63641871, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (57804429..57849265, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (64063757..64108589, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 5 Neighboring gene glycine C-acetyltransferase pseudogene 1 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 2 Neighboring gene RNA, U6 small nuclear 597, pseudogene Neighboring gene RNA, U6 small nuclear 1162, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:64108177-64108836 Neighboring gene uncharacterized LOC105370532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8513 Neighboring gene uncharacterized LOC124903437 Neighboring gene uncharacterized LOC124903439

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. O-GlcNAcylation of SPOP promotes carcinogenesis in hepatocellular carcinoma. Zhou P, et al. Oncogene, 2023 Mar. PMID 36604567
  2. Nucleolar proteome dynamics. Andersen JS, et al. Nature, 2005 Jan 6. PMID 15635413
  3. WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks. Caron P, et al. Genes Dev, 2019 Jun 1. PMID 31048545, Free PMC Article
  4. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Gordon DE, et al. Science, 2020 Dec 4. PMID 33060197, Free PMC Article
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC9907

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in corpus callosum development IEA
Inferred from Electronic Annotation
more info
  
involved_in ventricular system development IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
WD repeat-containing protein 89

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008726.3 → NP_001008726.1  WD repeat-containing protein 89

    See identical proteins and their annotated locations for NP_001008726.1

    Status: VALIDATED

    Source sequence(s)
    BC010698, BP278550, DA882425
    Consensus CDS
    CCDS9759.1
    UniProtKB/Swiss-Prot
    Q96FK6
    Conserved Domains (2) summary
    sd00039
    Location:74 → 112
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:41 → 349
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001258272.2 → NP_001245201.1  WD repeat-containing protein 89

    See identical proteins and their annotated locations for NP_001245201.1

    Status: VALIDATED

    Source sequence(s)
    BC010698, BP278550, DA882425, DB178690
    Consensus CDS
    CCDS9759.1
    UniProtKB/Swiss-Prot
    Q96FK6
    Related
    ENSP00000267522.3, ENST00000267522.7
    Conserved Domains (2) summary
    sd00039
    Location:74 → 112
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:41 → 349
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_001382423.1 → NP_001369352.1  WD repeat-containing protein 89

    Status: VALIDATED

    Source sequence(s)
    AL136038
    Consensus CDS
    CCDS9759.1
    UniProtKB/Swiss-Prot
    Q96FK6
    Conserved Domains (2) summary
    sd00039
    Location:74 → 112
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:41 → 349
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. NM_001382424.1 → NP_001369353.1  WD repeat-containing protein 89

    Status: VALIDATED

    Source sequence(s)
    AL136038
    Consensus CDS
    CCDS9759.1
    UniProtKB/Swiss-Prot
    Q96FK6
    Conserved Domains (2) summary
    sd00039
    Location:74 → 112
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:41 → 349
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. NM_001382425.1 → NP_001369354.1  WD repeat-containing protein 89

    Status: VALIDATED

    Source sequence(s)
    AL136038
    Consensus CDS
    CCDS9759.1
    UniProtKB/Swiss-Prot
    Q96FK6
    Conserved Domains (2) summary
    sd00039
    Location:74 → 112
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:41 → 349
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. NM_001382426.1 → NP_001369355.1  WD repeat-containing protein 89

    Status: VALIDATED

    Source sequence(s)
    AL136038
    Consensus CDS
    CCDS9759.1
    UniProtKB/Swiss-Prot
    Q96FK6
    Conserved Domains (2) summary
    sd00039
    Location:74 → 112
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:41 → 349
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. NM_001382427.1 → NP_001369356.1  WD repeat-containing protein 89

    Status: VALIDATED

    Source sequence(s)
    AL136038
    Consensus CDS
    CCDS9759.1
    UniProtKB/Swiss-Prot
    Q96FK6
    Conserved Domains (2) summary
    sd00039
    Location:74 → 112
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:41 → 349
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  8. NM_001382428.1 → NP_001369357.1  WD repeat-containing protein 89

    Status: VALIDATED

    Source sequence(s)
    AL136038
    Consensus CDS
    CCDS9759.1
    UniProtKB/Swiss-Prot
    Q96FK6
    Conserved Domains (2) summary
    sd00039
    Location:74 → 112
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:41 → 349
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  9. NM_001382429.1 → NP_001369358.1  WD repeat-containing protein 89

    Status: VALIDATED

    Source sequence(s)
    AL136038
    Consensus CDS
    CCDS9759.1
    UniProtKB/Swiss-Prot
    Q96FK6
    Conserved Domains (2) summary
    sd00039
    Location:74 → 112
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:41 → 349
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  10. NM_080666.4 → NP_542397.1  WD repeat-containing protein 89

    See identical proteins and their annotated locations for NP_542397.1

    Status: VALIDATED

    Source sequence(s)
    BC010698, DA882425
    Consensus CDS
    CCDS9759.1
    UniProtKB/Swiss-Prot
    Q96FK6
    Related
    ENSP00000480112.1, ENST00000620954.2
    Conserved Domains (2) summary
    sd00039
    Location:74 → 112
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:41 → 349
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    63597039..63641871 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536383.3 → XP_011534685.1  WD repeat-containing protein 89 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:69 → 387
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:112 → 150
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:79 → 387
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    57804429..57849265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375310.1 → XP_054231285.1  WD repeat-containing protein 89 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96FK6.1 GenPept UniProtKB/Swiss-Prot:Q96FK6

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