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CHRM3 cholinergic receptor muscarinic 3 [ Homo sapiens (human) ]

Gene ID: 1131, updated on 2-Nov-2024

Summary

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Official Symbol
CHRM3provided by HGNC
Official Full Name
cholinergic receptor muscarinic 3provided by HGNC
Primary source
HGNC:HGNC:1952
See related
Ensembl:ENSG00000133019 MIM:118494; AllianceGenome:HGNC:1952
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HM3; PBS; EGBRS; m3AChR
Summary
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]
Expression
Biased expression in brain (RPKM 5.0), salivary gland (RPKM 2.4) and 12 other tissues See more
Orthologs
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Genomic context

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See CHRM3 in Genome Data Viewer
Location:
1q43
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (239386568..239915450)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (238798998..239328607)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (239549868..240078750)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904566 Neighboring gene uncharacterized LOC105373223 Neighboring gene Sharpr-MPRA regulatory region 1169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:239550590-239551090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:239551091-239551591 Neighboring gene uncharacterized LOC105373225 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:239869465-239869994 Neighboring gene CHRM3 antisense RNA 2 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:239973609-239974110 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:239974613-239975113 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:239974111-239974612 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:239973107-239973608 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:239977657-239978198 Neighboring gene NANOG hESC enhancer GRCh37_chr1:239996955-239997498 Neighboring gene uncharacterized LOC124904567 Neighboring gene uncharacterized LOC105373224 Neighboring gene CHRM3 antisense RNA 1 Neighboring gene 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) pseudogene Neighboring gene ribosomal protein S7 pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Comparison of selective M3 and nonselective muscarinic receptor antagonists on gastrointestinal transit and bowel habits in humans. Bharucha AE, et al. Am J Physiol Gastrointest Liver Physiol, 2010 Jul. PMID 20395537, Free PMC Article
  2. Hypomethylation of long interspersed nuclear element-1 (LINE-1) leads to activation of proto-oncogenes in human colorectal cancer metastasis. Hur K, et al. Gut, 2014 Apr. PMID 23704319, Free PMC Article
  3. Cholinergic urticaria: studies on the muscarinic cholinergic receptor M3 in anhidrotic and hypohidrotic skin. Sawada Y, et al. J Invest Dermatol, 2010 Nov. PMID 20613776
  4. High expression of M3 muscarinic acetylcholine receptor is a novel biomarker of poor prognostic in patients with non-small cell lung cancer. Wu J, et al. Tumour Biol, 2013 Dec. PMID 23838802
  5. Investigation of antimuscarinic receptor autoantibodies in patients with acquired idiopathic generalized anhidrosis. Asahina M, et al. Intern Med, 2013. PMID 24334576

See all (188) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The M3 Muscarinic Acetylcholine Receptor Can Signal through Multiple G Protein Families.
    Title: The M3 Muscarinic Acetylcholine Receptor Can Signal through Multiple G Protein Families.
  2. Associations of genetic variations in the M3 receptor with salt sensitivity, longitudinal changes in blood pressure and the incidence of hypertension in Chinese adults.
    Title: Associations of genetic variations in the M3 receptor with salt sensitivity, longitudinal changes in blood pressure and the incidence of hypertension in Chinese adults.
  3. Muscarinic Acetylcholine Receptor M3 Expression and Survival in Human Colorectal Carcinoma-An Unexpected Correlation to Guide Future Treatment?
    Title: Muscarinic Acetylcholine Receptor M3 Expression and Survival in Human Colorectal Carcinoma-An Unexpected Correlation to Guide Future Treatment?
  4. CHRM3-Associated miRNAs May Play a Role in Bile Acid-Induced Proliferation of H508 Colon Cancer Cells.
    Title: CHRM3-Associated miRNAs May Play a Role in Bile Acid-Induced Proliferation of H508 Colon Cancer Cells.
  5. Impaired sweating in patients with cholinergic urticaria is linked to low expression of acetylcholine receptor CHRM3 and acetylcholine esterase in sweat glands.
    Title: Impaired sweating in patients with cholinergic urticaria is linked to low expression of acetylcholine receptor CHRM3 and acetylcholine esterase in sweat glands.
  6. Expression of M3 muscarinic acetylcholine receptors in gastric cancer.
    Title: Expression of M3 muscarinic acetylcholine receptors in gastric cancer.
  7. Methylation-reprogrammed CHRM3 results in vascular dysfunction in the human umbilical vein following IVF-ETdagger.
    Title: Methylation-reprogrammed CHRM3 results in vascular dysfunction in the human umbilical vein following IVF-ET†.
  8. Muscarinic receptor M3 contributes to vascular and neural growth factor up-regulation in severe asthma.
    Title: Muscarinic receptor M3 contributes to vascular and neural growth factor up-regulation in severe asthma.
  9. M3 muscarinic acetylcholine receptor-reactive Th17 cells in primary Sjogren's syndrome.
    Title: M3 muscarinic acetylcholine receptor-reactive Th17 cells in primary Sjögren's syndrome.
  10. Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK-YAP signaling axis.
    Title: Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK-YAP signaling axis.
Submit: New GeneRIF Correction See all GeneRIFs (131)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Prune belly syndrome
MedGen: C0033770 OMIM: 100100 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2023-11-16)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2023-11-16)

ClinGen Genome Curation Page

EBI GWAS Catalog

Description
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
EBI GWAS Catalog
Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.
EBI GWAS Catalog
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
EBI GWAS Catalog
Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32
EBI GWAS Catalog
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CHRM3 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled acetylcholine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables acetylcholine binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol phospholipase C activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled serotonin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in acetylcholine receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcium-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ion channel modulating, G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ligand-gated ion channel signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development TAS
Traceable Author Statement
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein modification process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within regulation of monoatomic ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of smooth muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in saliva secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic transmission, cholinergic IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
muscarinic acetylcholine receptor M3
Names
acetylcholine receptor, muscarinic 3
m3 muscarinic receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032046.2 RefSeqGene

    Range
    4639..533521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000740.4 → NP_000731.1  muscarinic acetylcholine receptor M3

    See identical proteins and their annotated locations for NP_000731.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Both variants 1 and 2 encode the same protein. The 5' end of this transcript contains L1 element sequence, initiates from an L1 element promoter and expression was predominantly found in placenta. (PMID: 19669628)
    Source sequence(s)
    AF279779, AL356361, AL357499, BQ772140
    Consensus CDS
    CCDS1616.1
    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
    UniProtKB/TrEMBL
    Q96RG9
    Related
    ENSP00000255380.4, ENST00000255380.8
    Conserved Domains (3) summary
    cd15299
    Location:66 → 270
    7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:487 → 512
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:484 → 564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. NM_001347716.2 → NP_001334645.1  muscarinic acetylcholine receptor M3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer variant. Both variants 1 and 2 encode the same protein. The 5' end of this transcript contains long terminal repeat (LTR) sequence, initiates from an LTR promoter and expression was predominantly found in testis. (PMID: 19669628)
    Source sequence(s)
    AC099564, AC104460, AL356361, AL357499, AL513543, BQ772140
    Consensus CDS
    CCDS1616.1
    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
    UniProtKB/TrEMBL
    Q96RG9
    Conserved Domains (3) summary
    cd15299
    Location:66 → 270
    7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:487 → 512
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:484 → 564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. NM_001375978.1 → NP_001362907.1  muscarinic acetylcholine receptor M3

    Status: REVIEWED

    Source sequence(s)
    AC099564, AC104460, AL356361, AL357499, AL513543
    Consensus CDS
    CCDS1616.1
    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
    UniProtKB/TrEMBL
    Q96RG9
    Related
    ENSP00000502667.1, ENST00000676153.1
    Conserved Domains (3) summary
    cd15299
    Location:66 → 270
    7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:487 → 512
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:484 → 564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. NM_001375979.1 → NP_001362908.1  muscarinic acetylcholine receptor M3

    Status: REVIEWED

    Source sequence(s)
    AC099564, AC104460, AL356361, AL513543
    Consensus CDS
    CCDS1616.1
    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
    UniProtKB/TrEMBL
    Q96RG9
    Conserved Domains (3) summary
    cd15299
    Location:66 → 270
    7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:487 → 512
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:484 → 564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  5. NM_001375980.1 → NP_001362909.1  muscarinic acetylcholine receptor M3

    Status: REVIEWED

    Source sequence(s)
    AC099564, AC104460, AL356361, AL513543
    Consensus CDS
    CCDS1616.1
    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
    UniProtKB/TrEMBL
    Q96RG9
    Conserved Domains (3) summary
    cd15299
    Location:66 → 270
    7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:487 → 512
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:484 → 564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  6. NM_001375981.1 → NP_001362910.1  muscarinic acetylcholine receptor M3

    Status: REVIEWED

    Source sequence(s)
    AC099564, AC104460, AL356361, AL357499, AL513543
    Consensus CDS
    CCDS1616.1
    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
    UniProtKB/TrEMBL
    Q96RG9
    Conserved Domains (3) summary
    cd15299
    Location:66 → 270
    7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:487 → 512
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:484 → 564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  7. NM_001375982.1 → NP_001362911.1  muscarinic acetylcholine receptor M3

    Status: REVIEWED

    Source sequence(s)
    AC099564, AC104460, AL356361, AL357499, AL513543
    Consensus CDS
    CCDS1616.1
    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
    UniProtKB/TrEMBL
    Q96RG9
    Related
    ENSP00000502349.1, ENST00000675184.1
    Conserved Domains (3) summary
    cd15299
    Location:66 → 270
    7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:487 → 512
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:484 → 564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  8. NM_001375983.1 → NP_001362912.1  muscarinic acetylcholine receptor M3

    Status: REVIEWED

    Source sequence(s)
    AC099564, AC104460, AL356361, AL513543
    Consensus CDS
    CCDS1616.1
    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
    UniProtKB/TrEMBL
    Q96RG9
    Conserved Domains (3) summary
    cd15299
    Location:66 → 270
    7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:487 → 512
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:484 → 564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  9. NM_001375984.1 → NP_001362913.1  muscarinic acetylcholine receptor M3

    Status: REVIEWED

    Source sequence(s)
    AC099564, AC104460, AL356361, AL357499, AL513543
    Consensus CDS
    CCDS1616.1
    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
    UniProtKB/TrEMBL
    Q96RG9
    Conserved Domains (3) summary
    cd15299
    Location:66 → 270
    7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:487 → 512
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:484 → 564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  10. NM_001375985.1 → NP_001362914.1  muscarinic acetylcholine receptor M3

    Status: REVIEWED

    Source sequence(s)
    AC099564, AC104460, AL356361, AL513543
    Consensus CDS
    CCDS1616.1
    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
    UniProtKB/TrEMBL
    Q96RG9
    Conserved Domains (3) summary
    cd15299
    Location:66 → 270
    7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:487 → 512
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:484 → 564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RNA

  1. NR_164748.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC099564, AC104460, AL357499, AL513543
    Related
    ENST00000468573.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    239386568..239915450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443115.1 → XP_047299071.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  2. XM_047443164.1 → XP_047299120.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  3. XM_011544043.3 → XP_011542345.1  muscarinic acetylcholine receptor M3 isoform X1

    See identical proteins and their annotated locations for XP_011542345.1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
    UniProtKB/TrEMBL
    Q96RG9
    Conserved Domains (3) summary
    cd15299
    Location:66 → 270
    7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:487 → 512
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:484 → 564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. XM_011544044.3 → XP_011542346.1  muscarinic acetylcholine receptor M3 isoform X1

    See identical proteins and their annotated locations for XP_011542346.1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
    UniProtKB/TrEMBL
    Q96RG9
    Conserved Domains (3) summary
    cd15299
    Location:66 → 270
    7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:487 → 512
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:484 → 564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  5. XM_011544047.3 → XP_011542349.1  muscarinic acetylcholine receptor M3 isoform X1

    See identical proteins and their annotated locations for XP_011542349.1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
    UniProtKB/TrEMBL
    Q96RG9
    Conserved Domains (3) summary
    cd15299
    Location:66 → 270
    7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:487 → 512
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:484 → 564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  6. XM_047443128.1 → XP_047299084.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  7. XM_017000159.2 → XP_016855648.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
    UniProtKB/TrEMBL
    Q96RG9
    Conserved Domains (3) summary
    cd15299
    Location:66 → 270
    7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:487 → 512
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:484 → 564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  8. XM_047443148.1 → XP_047299104.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  9. XM_047443223.1 → XP_047299179.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  10. XM_047443157.1 → XP_047299113.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  11. XM_047443178.1 → XP_047299134.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  12. XM_017000162.2 → XP_016855651.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
    UniProtKB/TrEMBL
    Q96RG9
    Conserved Domains (3) summary
    cd15299
    Location:66 → 270
    7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:487 → 512
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:484 → 564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  13. XM_047443199.1 → XP_047299155.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  14. XM_047443206.1 → XP_047299162.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  15. XM_047443244.1 → XP_047299200.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  16. XM_047443119.1 → XP_047299075.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
    Related
    ENSP00000482377.1, ENST00000615928.5

  17. XM_017000152.3 → XP_016855641.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
    UniProtKB/TrEMBL
    Q96RG9
    Conserved Domains (3) summary
    cd15299
    Location:66 → 270
    7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:487 → 512
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:484 → 564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  18. XM_017000154.2 → XP_016855643.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
    UniProtKB/TrEMBL
    Q96RG9
    Conserved Domains (3) summary
    cd15299
    Location:66 → 270
    7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:487 → 512
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:484 → 564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  19. XM_017000157.3 → XP_016855646.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
    UniProtKB/TrEMBL
    Q96RG9
    Conserved Domains (3) summary
    cd15299
    Location:66 → 270
    7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:487 → 512
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:484 → 564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  20. XM_047443239.1 → XP_047299195.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  21. XM_017000160.3 → XP_016855649.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
    UniProtKB/TrEMBL
    Q96RG9
    Conserved Domains (3) summary
    cd15299
    Location:66 → 270
    7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:487 → 512
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:484 → 564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  22. XM_017000163.3 → XP_016855652.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
    UniProtKB/TrEMBL
    Q96RG9
    Conserved Domains (3) summary
    cd15299
    Location:66 → 270
    7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:487 → 512
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:484 → 564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    238798998..239328607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334025.1 → XP_054190000.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  2. XM_054334031.1 → XP_054190006.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  3. XM_054334024.1 → XP_054189999.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  4. XM_054334023.1 → XP_054189998.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  5. XM_054334027.1 → XP_054190002.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  6. XM_054334028.1 → XP_054190003.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  7. XM_054334034.1 → XP_054190009.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  8. XM_054334029.1 → XP_054190004.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  9. XM_054334041.1 → XP_054190016.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  10. XM_054334030.1 → XP_054190005.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  11. XM_054334032.1 → XP_054190007.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  12. XM_054334039.1 → XP_054190014.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  13. XM_054334036.1 → XP_054190011.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  14. XM_054334037.1 → XP_054190012.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  15. XM_054334043.1 → XP_054190018.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  16. XM_054334026.1 → XP_054190001.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  17. XM_054334033.1 → XP_054190008.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  18. XM_054334038.1 → XP_054190013.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  19. XM_054334042.1 → XP_054190017.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  20. XM_054334035.1 → XP_054190010.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60

  21. XM_054334040.1 → XP_054190015.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309, Q0VAJ8, Q4QRI3, Q5VXY2, Q9HB60
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20309.1 GenPept UniProtKB/Swiss-Prot:P20309

Gene LinkOut

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