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nots nothepsin [ Danio rerio (zebrafish) ]

Gene ID: 114367, updated on 4-Jan-2025

Summary

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Official Symbol
notsprovided by ZNC
Official Full Name
nothepsinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-010620-1
See related
Ensembl:ENSDARG00000099824 AllianceGenome:ZFIN:ZDB-GENE-010620-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
LAP; ctsel; zgc:103608
Summary
Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in liver. [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
Annotation category: suggests misassembly
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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See nots in Genome Data Viewer
Location:
chromosome: 4
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (78010696..78020284, complement)
105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_008805374.1 (6656..16932)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene ras-related protein Rab-19-like Neighboring gene zgc:194336 Neighboring gene T-complex protein 1 subunit beta-like Neighboring gene chaperonin containing TCP1, subunit 2 (beta) Neighboring gene oocyte zinc finger protein XlCOF19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Oestrogen-induced expression of a novel liver-specific aspartic proteinase in Danio rerio (zebrafish). Riggio M, et al. Gene, 2002 Aug 7. PMID 12354659
  2. Global proteomics analysis of testis and ovary in adult zebrafish (Danio rerio). Groh KJ, et al. Fish Physiol Biochem, 2011 Sep. PMID 21229308, Free PMC Article
  3. Differential gene expression and biomarkers in zebrafish (Danio rerio) following exposure to produced water components. Holth TF, et al. Aquat Toxicol, 2008 Dec 11. PMID 18963085
  4. Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history. Castro LF, et al. Proc Biol Sci, 2014 Jan 22. PMID 24307675, Free PMC Article
  5. Revealing genes associated with vitellogenesis in the liver of the zebrafish (Danio rerio) by transcriptome profiling. Levi L, et al. BMC Genomics, 2009 Mar 31. PMID 19335895, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC192423

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nothepsin
Names
aspartic proteinase
NP_571879.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131804.1 → NP_571879.1  nothepsin

    See identical proteins and their annotated locations for NP_571879.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ278269
    UniProtKB/TrEMBL
    Q9DDE2
    Related
    ENSDARP00000130638.2, ENSDART00000159559.2
    Conserved Domains (3) summary
    pfam00026
    Location:85 → 403
    Asp; Eukaryotic aspartyl protease
    pfam07966
    Location:20 → 48
    A1_Propeptide; A1 Propeptide
    cl11403
    Location:86 → 403
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    78010696..78020284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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