tnfrsfa tumor necrosis factor receptor superfamily, member a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tnfrsfaprovided by ZNC
Official Full Name: tumor necrosis factor receptor superfamily, member aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010802-1
See related: Ensembl:ENSDARG00000004451 AllianceGenome:ZFIN:ZDB-GENE-010802-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: OTR; tnf; wu:fc27c09
Summary: Acts upstream of or within positive regulation of apoptotic process. Predicted to be located in membrane. Is expressed in several structures, including brain; germ ring; notochord; scale; and sensory system. Human ortholog(s) of this gene implicated in head and neck squamous cell carcinoma. Orthologous to several human genes including TNFRSF10B (TNF receptor superfamily member 10b). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (16172752..16219469, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (16076775..16123492, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tumor necrosis factor alpha has been shown to be both proapoptotic and mitogenic for hepatocytes and necessary for alcohol-induced liver injury.
Title: TNF alpha-induced Ras activation due to ethanol promotes hepatocyte proliferation independently of liver injury in the mouse.
ER stress demonstrated by RT-PCR of mRNA of selective ER stress markers GRP78, CHOP, and SREBP1 was increased equivalently in both types of mice.
Title: Role of TNF-alpha in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury.

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General gene information

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Markers

G45330 (e-PCR)
- UniSTS:106132

fc27c09.x1 (e-PCR)
- UniSTS:187878

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily, member a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131840.2 → NP_571915.2 tumor necrosis factor receptor superfamily, member a precursor

Status: VALIDATED

Source sequence(s)

CU571317, DQ812116, EB956321

UniProtKB/TrEMBL

A0A8M1P718, Q0PKX6

Related

ENSDARP00000107373.2, ENSDART00000124871.4

Conserved Domains (3) summary

cd08315
Location:349 → 433

Death_TRAILR_DR4_DR5; Death domain of Tumor necrosis factor-Related Apoptosis-Inducing Ligand Receptors

cd10580
Location:56 → 163

TNFRSF10; Tumor necrosis factor receptor superfamily member 10 (TNFRSF10), includes TNFRSF10A (DR4), TNFRSF10B (DR5), TNFRSF10C (DcR1) and TNFRSF10D (DcR2)

pfam14283
Location:142 → 241

DUF4366; Domain of unknown function (DUF4366)